A case report of fatal oral ingestion of resorcinol.

Resorcinol is a pharmaceutical agent used topically in dermatological treatments for acne, eczema, psoriasis and related skin conditions. Although there are a few studies that indicate chronic toxic effects of resorcinol on humans after topical application, information on the effects of resorcinol in acute poisoning after oral ingestion is limited. Thus, we wish to report the clinical and laboratory findings of a patient who was admitted to our emergency department (ED) after inadvertent oral ingestion of resorcinol and later died, as well as the patient's autopsy findings. The major clinical and laboratory findings were unconsciousness, respiratory failure that required mechanical ventilation, generalized tonic-clonic seizures, leukocytosis and severe metabolic acidosis. In the blood sample taken at the autopsy, a high level of methemoglobin was found. In the serum, resorcinol was revealed by gas chromatography-mass spectrometry. It can be concluded that the basic approach to patients with resorcinol poisoning should include initial stabilization of the patient by supporting the airway, respiration and circulation, and treating complications such as seizures or metabolic acidosis in the ED, as soon as possible after oral ingestion.

The oral toxicity of resorcinol during pregnancy: a case report.

Resorcinol (1,3 benzenediol; m-dihydroxybenzene: resorcin) is a pharmaceutical agent used topically in dermatological treatments such as acne and related skin conditions. It could also be used in combination with the other acne treatment agents such as sulphur. It could be very hazardous if taken orally and there are limited reports on its toxic effects in human. The present work aimed to report a resorcinol poisoning case in which resorcinol was taken accidentally by a woman at 30 weeks of pregnancy. The major clinical findings were unconsciousness, drowsiness, and respiratory failure that required mechanical ventilation along with tonic-clonic seizures and hypothermia. In addition, the laboratory findings were leucocytosis, high bilirubin levels, severe metabolic acidosis, and green-colored urine. The fetus was considered dead 24 h after delivery; however, mother's prognosis was well with supportive management. It could be concluded that the basic approach to the patient with resorcinol poisoning should include the initial stabilization of immediate life-threatening problems and elimination of the toxin. This is the first report on resorcinol poisoning in pregnant women, indicating its major clinical and laboratory findings.

Apparent zearalenone intoxication in a dairy herd from feeding spoiled acid-treated corn.

High-moisture corn was treated with a propionic acid preservative and stored in a 40,000 bushel steel bin. This corn heated and spoiled in storage and subsequently was retreated with the preservative. The out-of-condition corn was used as an ingredient in the ration for a dairy herd of cows and replacement heifers. The finished feed was cultured for fungi and assayed for mycotoxins. Results were 750,000 Fusarium spp colonies/g of feed, and 1.5 mg zearaleonone and 1.0 mg deoxynivalenol/kg of feed. Frequent episodes of behavioral estrus of 2 to 5 d duration, that were not synchronized with the ovarian cycle, were observed. Cows in the second and third trimester of pregnancy also has episodes of behavioral estrus. Idiopathic vaginitis was diagnosed. Mammary development occurred in the prepubertal heifers. Cows bred in true estrus were found in true estrus 35 to 55 d later. All of the heifers with precocious mammary development were subsequently culled from the herd because of sterility.

[Hyperestrogenism in swine due to natural poisoning with zearalenone]. / Hiperestrogenismo en cerdas por intoxicación natural con zearalenona.

A field case is described in which all prepuberal swine of a group of 20 pigs and 11 sows showed marked estrogenic effects. These consisted of enlarged mammary glands, swelled tumefacient vulva, and greatly enlarged internal reproductive organs. The corn used to feed these animals was found to contain 56 ppm zearalenone. Deoxynivalenol (4.9 ppm) was found in the corn; T-2 toxin, nivalenol, fusarenon-X, diacetoxyscirpenol, aflatoxins and ochratoxins were absent. Identity of Z was confirmed by TLC in four solvent systems, behavior of the suspected spots under UV light of different wavelengths, change of fluorescence from green to blue after spraying with 5% AlCl3 in alcohol and heating at 110 degrees C during 5 minutes, and by its UV spectrum. A zearalenone producing strain of Fusarium oxysporum was isolated from the suspected grain. Histopathology of uterine tissue showed typical changes produced by zearalenone: hyperplasia, hypertrophy, and metaplasia of the myometrium. Feeding of the grain to a prepuberal sow under controlled conditions reproduced all the effect found in the farm animals. This is the first field case of zearalenone poisoning reported in Argentina.

Hiperestrogenismo en cerdas por intoxicación natural con zearalenona / Hyperestrogenism in swine due to natural poisoning with zearalenone

Se describe un caso de intoxicación de cerdas prepúberes con zearalenona (Z) al consumir una dieta conteniendo 56 ppm Z. En el maíz contaminado se encontró una cepa de Fusarium oxysporum que produjo Z en cultivo sobre ese grano. Se indicaron la evidencias de distinta índole que permitieron confirmar que los efecto observados fueron producidos por dicha micotoxina (AU)

Hiperestrogenismo en cerdas por intoxicación natural con zearalenona / Hyperestrogenism in swine due to natural poisoning with zearalenone

Se describe un caso de intoxicación de cerdas prepúberes con zearalenona (Z) al consumir una dieta conteniendo 56 ppm Z. En el maíz contaminado se encontró una cepa de Fusarium oxysporum que produjo Z en cultivo sobre ese grano. Se indicaron la evidencias de distinta índole que permitieron confirmar que los efecto observados fueron producidos por dicha micotoxina

Zearalenone intoxication of pigs.

Mycotoxicosis due to ingestion of zearalenone was detected on 2 pig farms on the Atherton Tableland in northern Queensland. In one herd of 200 pigs, this resulted from feeding maize which had been stored with a high moisture content. In the other herd of 1400 pigs, it resulted from feeding sorghum grain which was rain affected before harvest. Concentrations of zearalenone in the feeds ranged up to 8 mg/kg. Most prepubertal gilts in the herds displayed enlarged teats and signs of oestrus such as having red, swollen vulvas. In several cases both rectal and vaginal prolapses occurred. On one of the farms, 25 pigs died as a direct result of prolapses. Autopsy of a 3-month-old gilt revealed apparently enlarged ovaries and uterine horns. Sows and boars seemed to be unaffected. Four gilts failed to conceive following mating during the period of zearalenone ingestion, but apart from this and the deaths from prolapses, production of the herds appeared to be unaffected.