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1.
Curr Med Sci ; 44(3): 657-666, 2024 Jun.
Article in English | MEDLINE | ID: mdl-38748367

ABSTRACT

Maxillary protrusion combined with mandibular retraction is a highly prevalent but extremely complex maxillofacial deformity that can have a serious negative impact on patients' facial aesthetics and mental health. The traditional orthodontic treatment strategy often involves extracting 4 first premolars and conventional fixed techniques, combined with mini-implant screws, to retract the anterior teeth and improve facial protrusion. In recent years, an invisible orthodontic technique, without brackets, has become increasingly popular. However, while an invisible aligner has been used in some cases with reasonable results, there remain significant challenges in achieving a perfect outcome. This case report presents an adolescent patient with bimaxillary protrusion and mandibular retrognathia. Based on the characteristics of the invisible aligners and the growth characteristics of the adolescent's teeth and jawbone, we designed precise three-dimensional tooth movement and corresponding resistance/over-correction for each tooth, while utilizing the patient's jawbone growth potential to promote rapid development of the mandible, accurately and efficiently correcting bimaxillary protrusion and skeletal mandibular retrognathia. The patient's facial aesthetics, especially the lateral morphology, have been greatly improved, and various aesthetic indicators have also shown significant changes, and to the patient's great benefit, invasive mini-implant screws were not used during the treatment. This case highlights the advantages of using invisible aligners in adolescent maxillary protrusion combined with mandibular retraction patients. Furthermore, comprehensive and accurate design combined with good application of growth potential can also enable invisible orthodontic technology to achieve perfect treatment effects in tooth extractions, providing clinical guidance for orthodontists.


Subject(s)
Mandible , Humans , Adolescent , Mandible/surgery , Female , Tooth Movement Techniques/methods , Retrognathia/surgery , Retrognathia/therapy , Retrognathia/diagnostic imaging , Maxilla/surgery , Male
2.
J Oral Maxillofac Surg ; 82(2): 181-190, 2024 02.
Article in English | MEDLINE | ID: mdl-37995761

ABSTRACT

BACKGROUND: Jaw deformity diagnosis requires objective tests. Current methods, like cephalometry, have limitations. However, recent studies have shown that machine learning can diagnose jaw deformities in two dimensions. Therefore, we hypothesized that a multilayer perceptron (MLP) could accurately diagnose jaw deformities in three dimensions (3D). PURPOSE: Examine the hypothesis by focusing on anomalous mandibular position. We aimed to: (1) create a machine learning model to diagnose mandibular retrognathism and prognathism; and (2) compare its performance with traditional cephalometric methods. STUDY DESIGN, SETTING, SAMPLE: An in-silico experiment on deidentified retrospective data. The study was conducted at the Houston Methodist Research Institute and Rensselaer Polytechnic Institute. Included were patient records with jaw deformities and preoperative 3D facial models. Patients with significant jaw asymmetry were excluded. PREDICTOR VARIABLES: The tests used to diagnose mandibular anteroposterior position are: (1) SNB angle; (2) facial angle; (3) mandibular unit length (MdUL); and (4) MLP model. MAIN OUTCOME VARIABLE: The resultant diagnoses: normal, prognathic, or retrognathic. COVARIATES: None. ANALYSES: A senior surgeon labeled the patients' mandibles as prognathic, normal, or retrognathic, creating a gold standard. Scientists at Rensselaer Polytechnic Institute developed an MLP model to diagnose mandibular prognathism and retrognathism using the 3D coordinates of 50 landmarks. The performance of the MLP model was compared with three traditional cephalometric measurements: (1) SNB, (2) facial angle, and (3) MdUL. The primary metric used to assess the performance was diagnostic accuracy. McNemar's exact test tested the difference between traditional cephalometric measurement and MLP. Cohen's Kappa measured inter-rater agreement between each method and the gold standard. RESULTS: The sample included 101 patients. The diagnostic accuracy of SNB, facial angle, MdUL, and MLP were 74.3, 74.3, 75.3, and 85.2%, respectively. McNemar's test shows that our MLP performs significantly better than the SNB (P = .027), facial angle (P = .019), and MdUL (P = .031). The agreement between the traditional cephalometric measurements and the surgeon's diagnosis was fair. In contrast, the agreement between the MLP and the surgeon was moderate. CONCLUSION AND RELEVANCE: The performance of the MLP is significantly better than that of the traditional cephalometric measurements.


Subject(s)
Jaw Abnormalities , Malocclusion, Angle Class III , Prognathism , Retrognathia , Humans , Prognathism/diagnostic imaging , Retrognathia/diagnostic imaging , Retrospective Studies , Mandible/diagnostic imaging , Mandible/abnormalities , Malocclusion, Angle Class III/surgery , Cephalometry/methods
3.
Eur J Pediatr ; 182(12): 5501-5510, 2023 Dec.
Article in English | MEDLINE | ID: mdl-37777602

ABSTRACT

Twin-block appliance had been advocated as a potential treatment option in paediatric obstructive sleep apnoea (OSA) due to their favourable effect in enhancing upper airway parameters and improving OSA symptoms. The aim of this study was to evaluate the effect of twin-block appliance therapy on upper airway parameters/dimensions and the apnoea-hypopnea indexes (AHIs) in OSA children with class II mandibular retrognathic skeletal malocclusion using cone-beam computed tomography. This prospective longitudinal study comprised 34 polysomnography-proven OSA growing children with class II mandibular retrognathic skeletal malocclusion between the ages of 8 and 12 years who had completed myofunctional twin-block therapy and matched corresponding controls. The upper airway was segmented into the nasopharynx, oropharynx, and hypopharynx, and the effect of twin-bock treatment on upper airway parameters/dimensions was assessed pre- and posttreatment using CBCT analysis, while a second standard overnight PSG was performed to determine changes in the AHI. At the nasopharynx level, minimal (nonsignificant) increases in all variables were observed within the twin-block group and between the groups (P > 0.05). At the level of the oropharynx, all variables increased significantly in the treatment group and between groups (P < 0.001), but these increases were nonsignificant in the control group. At the level of the hypopharynx, only the minimum cross-sectional area (MCA) increased significantly in the treatment group (P = 0.003). The change in MCA was also significant between the groups (P = 0.041). In addition, the upper airway length increased significantly in the twin-block group (P = 0.0154), and the AHI decreased by 74.8% (P < 0.001). CONCLUSION: Correction of class II mandibular retrognathic skeletal malocclusion with twin-block appliance resulted in a significant increase in upper airway volume, MCA, anteroposterior and lateral distances of the MCA at the level of the oropharynx, MCA at the level of the hypopharynx and upper airway length, and a significant decrease in AHI, but it had no effect on nasopharynx parameters. WHAT IS KNOWN: • CBCT imaging has been shown to be an effective and precise diagnostic tool for analyzing the upper airways and craniofacial structures. • Twin block appliance may be an effective treatment modality in children with OSA. WHAT IS NEW: • Minimal cross-sectional area of upper ways may be the most relevant potential parameter when explaining how the upper airway anatomy plays role of in the pathogenesis of pediatric OSA. • Twin block appliance induced favorable changes in upper airway morphology (oropharynx area mainly) and respiratory parameters in OSA children with class II malocclusion.


Subject(s)
Malocclusion, Angle Class II , Malocclusion , Retrognathia , Sleep Apnea, Obstructive , Spiral Cone-Beam Computed Tomography , Humans , Child , Retrognathia/diagnostic imaging , Retrognathia/therapy , Longitudinal Studies , Prospective Studies , Malocclusion, Angle Class II/complications , Malocclusion, Angle Class II/diagnostic imaging , Malocclusion, Angle Class II/therapy , Sleep Apnea, Obstructive/complications , Sleep Apnea, Obstructive/diagnostic imaging , Sleep Apnea, Obstructive/therapy , Cephalometry/methods
4.
Int Orthod ; 21(3): 100782, 2023 09.
Article in English | MEDLINE | ID: mdl-37295170

ABSTRACT

Date of birth>09/06/2004; sex: female. Pre-treatment documents>13years 4months old: 07/07/2017. Diagnosis>Skeletal class II with mandibular retrusion, normodivergent facial pattern; class II division 2. Treatment planning>bimaxillary buccal fixed appliance. Duration of active treatment>29months. Post-treatment documents>15years 6months; 20/12/2019. Post-retention documents>16years 7months old; 04/01/2021. Retention period>2years 9months and still continued.


Subject(s)
Malocclusion, Angle Class II , Micrognathism , Orthodontic Brackets , Orthodontics , Retrognathia , Humans , Female , Malocclusion, Angle Class II/diagnostic imaging , Malocclusion, Angle Class II/therapy , Orthodontics, Corrective , Retrognathia/diagnostic imaging , Retrognathia/therapy , Cephalometry , Orthodontic Appliances, Fixed
5.
BMC Oral Health ; 22(1): 149, 2022 04 28.
Article in English | MEDLINE | ID: mdl-35484618

ABSTRACT

BACKGROUND: Only a few studies have used 3D cone-beam computed tomography (CBCT) analysis to evaluate the positional and morphological characteristics of the temporomandibular joint (TMJ) in adults with skeletal Class II. No studies have focused on the case of skeletal Class II with mandibular retrognathism in different vertical skeletal patterns. As a result, this study aimed to evaluate and compare the position and morphology of TMJ in adults with skeletal Class II with mandibular retrognathism in different vertical skeletal patterns to the position and morphology of TMJ in the normal Chinese adult population in three dimensions. METHODS: This retrospective study analyzed CBCT images of 80 adult patients. Subjects with skeletal Class II with a normal sagittal position of the maxilla and mandibular retrognathism were classified according to the mandibular angle and facial height ratio into three groups of 20 subjects each: hypodivergent, normodivergent, and hyperdivergent groups, as well as a control group of 20 subjects. The following 3D measurements of TMJ were evaluated: (1) position, parameters, and inclination of the mandibular fossa; (2) position, parameters, and inclination of the mandibular condyle; (3) condyle centralization in their respective mandibular fossae; (4) anterior, posterior, superior, and medial joint spaces; and (5) 3D volumetric measurements of the TMJ spaces. Measurements were statistically analyzed by one-way ANOVA test, followed by Tukey's post hoc test. RESULTS: Significant differences were found in the hyperdivergent and hypodivergent groups compared with the normal group in the vertical and anteroposterior mandibular fossa position, vertical condylar inclination, and condylar width and length. The hyperdivergent group showed the significantly highest condylar inclination with the midsagittal plane; anterior and superior positioning of the condyle; smallest anterior, superior, and medial joint spaces; and largest volumetric total joint space relative to the two other groups. CONCLUSIONS: The condyle-fossa position and morphology differ with various vertical facial patterns in individuals with skeletal Class II mandibular retrognathism. These differences could be considered during TMD diagnosis and orthodontic treatment.


Subject(s)
Malocclusion , Retrognathia , Adult , Humans , Mandibular Condyle/anatomy & histology , Mandibular Condyle/diagnostic imaging , Retrognathia/diagnostic imaging , Retrospective Studies , Temporomandibular Joint/diagnostic imaging
6.
J Craniofac Surg ; 33(2): 521-525, 2022.
Article in English | MEDLINE | ID: mdl-34669681

ABSTRACT

ABSTRACT: This study aims to introduce a new sagittal cephalometric measurement, the sagittal G-triangle analysis, to accurately and reproducibly assess the sagittal jaw relationship. Sagittal G-triangle analysis, which consists of angles AXK and BXK, is based on an equilateral triangle (Bo-X-K) constructed using 5 cephalometric landmarks (Ba, Bo, Po, Or, and G). To test the diagnostic efficiency of this analysis, pretreatment cephalometric radiographs of 120 female and 120 male Chinese patients were randomly selected. For each enlisted subject, angles SNA and SNB as well as angles AXK and BXK were measured and recorded. On the basis of the SNA and SNB results, subjects were categorized into 6 groups: maxillary retrognathism, normal maxilla, maxillary prognathism, mandibular retrognathism, normal mandible, and mandibular prognathism. The diagnostic efficiency of angles AXK and BXK were evaluated using various statistical tests. A high correlation was detected between angles SNA and AXK as well as between angles SNB and BXK. Female patients with angle AXK between -2.255° and 2.860° and male patients with angle AXK between -2.615° and 2.120° were considered to have a normal maxilla position. Female patients with angle BXK between -2.61° and 2.93° and male patients with angle BXK between -2.275° and 0.610° were considered to have a normal mandible position. In conclusion, sagittal G-triangle analysis could be used as an alternative method for the evaluation of the sagittal position of the maxilla and mandible in cephalometric analysis.


Subject(s)
Malocclusion, Angle Class III , Malocclusion , Prognathism , Retrognathia , Cephalometry/methods , Female , Humans , Male , Mandible/diagnostic imaging , Maxilla/diagnostic imaging , Retrognathia/diagnostic imaging
7.
Orthod Craniofac Res ; 25(2): 212-218, 2022 May.
Article in English | MEDLINE | ID: mdl-34365733

ABSTRACT

OBJECTIVE: To evaluate the acceptance of orthodontists, laypeople and the patient when progressive mandibular advancements are performed in class II subjects with mandibular retrognathism. SETTING AND SAMPLE: 3D images were obtained by an optical surface scanning of fifteen individuals (12 males and three females, mean age of 23 years and 8 months) with mandibular retrognathism in three mandibular positions: maximum intercuspation (MIC) and progressive mandibular advancement of 2 and 4 mm. METHODS: The images (n = 45) were evaluated through a scale by two groups of panellist, 20 orthodontists, 20 laypeople and by the patients themselves (n = 15). The participants evaluated and rated each video and give scores between 0 and 10, according to their perception of facial harmony. MANOVA for repeated measures was used for intra- and intergroup differences and to evaluate the patients' self-perception. RESULTS: Laypeople reported better face acceptance than orthodontists in MIC and progressive mandibular advancement of 2 and 4 mm (P < .0001). 80% of the patients evaluated their own face as pleasant in MIC. Around half of them did not note significant difference following mandibular advancement of 2 mm as compared with MIC and even two-third attributed lower scores when the mandible was advanced 4 mm. CONCLUSION: A high variability was observed among all groups of raters. Patient´s opinion should be taken into account when mandibular advancement of 4 mm or more is planned. This study suggests that a thorough discussion of facial changes resulting from mandibular advancement should be carried out among professionals, parents and patients.


Subject(s)
Malocclusion, Angle Class II , Malocclusion , Mandibular Advancement , Retrognathia , Adult , Cephalometry , Female , Humans , Imaging, Three-Dimensional , Male , Malocclusion, Angle Class II/diagnostic imaging , Malocclusion, Angle Class II/therapy , Mandible , Mandibular Advancement/methods , Orthodontists , Retrognathia/diagnostic imaging , Young Adult
8.
Stomatologiia (Mosk) ; 100(6): 99-107, 2021.
Article in Russian | MEDLINE | ID: mdl-34953197

ABSTRACT

This article describes a case report of the patient with mandibular retrognathia, class II malocclusion, constriction and deformation of dental arches and bimaxillary protrusion. Due to the patient's refuse to undergo the orthognathic surgery, after diagnostic, it was decided to carry out the orthodontic dentoalveolar compensation. The combined use of the functional fixed telescopic appliance (FFTA), bracket system and orthodontic miniscrews made it possible to effectively normalize the mandibular position, achieve orthognathic occlusion, eliminate bimaxillary protrusion and improve the face profile. This method significantly reduced invasiveness and time of orthodontic treatment.


Subject(s)
Malocclusion, Angle Class II , Malocclusion , Retrognathia , Adult , Cephalometry , Humans , Malocclusion, Angle Class II/diagnostic imaging , Malocclusion, Angle Class II/therapy , Mandible/surgery , Retrognathia/diagnostic imaging , Retrognathia/surgery
9.
Am J Med Genet A ; 185(1): 46-49, 2021 01.
Article in English | MEDLINE | ID: mdl-33030227

ABSTRACT

Retrognathia (recessed chin) and prognathism (prominent chin) often present as signs of an underlying condition. Accurate clinical definitions are important. Yet their definitions were according to "clinical impression", or to seldom used X-ray criteria. We propose a statistical and anthropometric definition of retrognathia and prognathism based upon the ratio between the goniomaxillar length (distance between the gonion at the mandible angle and the subnasale and the goniomandibular length (distance between the mandible angle and the most anterior point of the bony chin). We assumed that an increase in the ratio indicates retrognathia and a decrease reflects prognathism. We conducted a prospective, observational, anthropometric study in 204 consecutive healthy term infants. Measurements took place on the second day of life, using sliding calipers. Mean ± SD of goniomandibular length (5.1 ± 0.3 cm), goniomaxillar length (5.4 ± 0.3 cm), were calculated. All measurements correlated significantly with gestational age, and with infant birthweight. The mean ± SD goniomaxillar length/goniomandibular length ratio was 1.06 ± 0.05. We defined a normal ratio as being within 2 SD of the mean, that is, between 0.96 and and 1.16. This ratio correlated with neither gestational age nor with birthweight. We conclude that the goniomaxillar length/goniomandibular length ratio can be calculated whenever retro - or prognathism is suspected. A ratio outside of the 95% confidence interval should help in making this diagnosis. An increase in this ratio beyond 2 SD above the mean (1.16) could be interpreted as retrognathia and a decrease beyond 2 SD below the mean (0.96) as prognathism.


Subject(s)
Cephalometry , Prognathism/diagnosis , Retrognathia/diagnosis , Adult , Chin/diagnostic imaging , Chin/pathology , Female , Gestational Age , Humans , Infant, Newborn , Male , Mandible/diagnostic imaging , Mandible/pathology , Maxilla/diagnostic imaging , Maxilla/pathology , Mothers , Prognathism/diagnostic imaging , Prognathism/pathology , Retrognathia/diagnostic imaging , Retrognathia/pathology
10.
Med Sci Monit ; 26: e921401, 2020 Jun 26.
Article in English | MEDLINE | ID: mdl-32588836

ABSTRACT

BACKGROUND The purpose of this prospective study was to compare adolescent and post-adolescent growth periods regarding the effectiveness of conventional activator appliance in patients with Class II mandibular retrognathia by using lateral cephalometric radiographs and three-dimensional photogrammetry (3dMDface). MATERIAL AND METHODS We enrolled 2 groups: 15 patients in the adolescent growth period and 17 patients in the post-adolescent growth period. All patients had Class II anomaly with mandibular retrognathia and were treated with conventional activator appliances. Lateral cephalometric radiographs and three-dimensional photogrammetric views were obtained at the beginning and end of the activator treatment of Class II patients. Maxillomandibular discrepancy, mandibular protrusion and lengths, convexity angles, facial heights, and dental measurements were evaluated cephalometrically. Projections of the lips and the chin and volumetric measurements of the lip and the mandibular area were assessed using three-dimensional photogrammetry. RESULTS Conventional activator therapy resulted in similar effects in both growth periods regarding improvements in the mandibular sagittal growth and maxillomandibular relationship (ANB° and the SNB° angles). Mandibular effective length was increased (Co-Gn length) and the maxillary horizontal growth was restricted (decreased SNA° angle) in both groups following the treatment. Treatment duration was significantly longer in the post-adolescent group. Increases in the projections of menton, pogonion, and sublabial points were observed in the three-dimensional photogrammetric views. Total lip volume was reduced while the mandibular volume was significantly increased in both groups. Lower gonial angle showed a greater increase in the post-adolescent group. CONCLUSIONS Correction of Class II anomaly with mandibular retrognathia was achieved with a combination of dental and skeletal changes in both growth periods. Conventional activator therapy may be an alternative treatment approach in the late growth period as it led to significant skeletal and dental changes.


Subject(s)
Activator Appliances , Malocclusion, Angle Class II/therapy , Mandible/diagnostic imaging , Retrognathia/therapy , Adolescent , Age Factors , Bone Development , Carpal Bones/diagnostic imaging , Carpal Bones/growth & development , Cephalometry , Child , Female , Hand Bones/diagnostic imaging , Hand Bones/growth & development , Humans , Imaging, Three-Dimensional , Male , Malocclusion, Angle Class II/diagnostic imaging , Mandible/abnormalities , Maxilla/diagnostic imaging , Maxillofacial Development , Photogrammetry , Prospective Studies , Retrognathia/diagnostic imaging , Treatment Outcome
11.
J Perinat Med ; 47(9): 969-978, 2019 Nov 26.
Article in English | MEDLINE | ID: mdl-31622251

ABSTRACT

Objective To determine whether the measurement of inferior facial angle (IFA) and prefrontal space ratio (PFSR) in two-dimensional (2D) ultrasound images in the first trimester of pregnancy is reliable and to describe these markers in normal and aneuploid fetuses. Methods IFA and PFSR were measured in stored 2D midsagittal images of 200 normal and 140 aneuploid fetal profiles between 11 + 0 and 13 + 6 weeks of gestation. Limits of agreement (LOAs) and intraclass correlation coefficients (ICCs) for inter- and intraobserver differences were calculated. Results The mean IFA in normal fetuses was 76.5° ± 6.3. Between the two measurement rounds of the same observer, the LOAs were -5.4 to 7.1 (obs. 1) and 7.4 to 8.4 (obs. 2). For IFA measurements by the same observer the ICC was 0.88 (obs. 1) and for measurements by two different observers the ICC was 0.74. The mean PFSR was 0.76 ± 0.40 and the intraobserver LOAs were -0.372 to 0.395 (obs. 1) and -0.555 to 0.667 (obs. 2). For PFSR measurements by the same observer the ICC was 0.89 (obs. 1) and for measurements by two different observers the ICC was 0.65. Among aneuploid fetuses, IFA was below the normal range in one third of the cases with trisomy 18. PFSR was below the 95% prediction limit in 16.2% of fetuses with trisomy 21% and 17.9% of fetuses with trisomy 18. Conclusion IFA can be reliably measured in 2D ultrasound images in the first trimester of pregnancy with a high interobserver agreement and may provide information about retrognathia associated with various syndromes and aneuploidies at early stages of pregnancy.


Subject(s)
Aneuploidy , Face/diagnostic imaging , Pregnancy Trimester, First , Retrognathia/diagnostic imaging , Ultrasonography, Prenatal/methods , Down Syndrome/diagnostic imaging , Down Syndrome/embryology , Face/embryology , Female , Humans , Male , Observer Variation , Pregnancy , Reproducibility of Results , Retrognathia/embryology , Retrognathia/genetics , Retrospective Studies , Trisomy 13 Syndrome/diagnostic imaging , Trisomy 13 Syndrome/embryology , Trisomy 18 Syndrome/diagnostic imaging , Trisomy 18 Syndrome/embryology , Turner Syndrome/diagnostic imaging , Turner Syndrome/embryology
12.
Int Orthod ; 17(2): 354-364, 2019 06.
Article in English | MEDLINE | ID: mdl-31036464

ABSTRACT

The Herbst appliance (HA) is considered an efficient method to treat class II malocclusion characterized by mandibular retrusion. Nevertheless, HA is although hampered by side effects reducing its therapeutic potentialities. The association between HA and TADs in the lower arch has proved to be very effective in controlling lower incisor flaring. This case report shows that the insertion of TADs in both arches offers a satisfactory control of the vertical dimension, by avoiding a maxillary clockwise inclination.


Subject(s)
Malocclusion, Angle Class II/therapy , Orthodontic Appliances, Functional , Retrognathia/therapy , Tooth Movement Techniques/methods , Adolescent , Bone Screws , Cephalometry , Humans , Incisor , Male , Malocclusion, Angle Class II/diagnostic imaging , Mandible , Maxilla , Orthodontic Anchorage Procedures/instrumentation , Orthodontic Appliance Design , Orthodontic Appliances, Fixed , Radiography, Panoramic , Retrognathia/diagnostic imaging , Tooth Movement Techniques/instrumentation , Treatment Outcome , Vertical Dimension
13.
J Radiol Case Rep ; 13(10): 1-5, 2019 Oct.
Article in English | MEDLINE | ID: mdl-32184920

ABSTRACT

Emanuel syndrome is a rare inherited chromosomal abnormality caused by an unbalanced translocation of chromosomes 11 and 22. Clinically, Emanuel syndrome is characterized by a wide spectrum of congenital anomalies, dysmorphisms, and developmental disability often confused with other similar syndromes. Outside of genetic testing, diagnosis remains challenging and current literature on typical radiologic findings is limited. We present classic neuroimaging findings of Emanuel syndrome consistent with prior literature including microcephaly, microretrognathia, external auditory canal stenosis, and cleft palate; and also introduce the additional maxillofacial anomaly of dysplastic middle ear ossicles, to our knowledge not previously described in the literature. Recognition of findings leading to earlier diagnosis of Emanuel syndrome may improve outcomes and quality of life for patients and their families.


Subject(s)
Chromosome Disorders/diagnostic imaging , Cleft Palate/diagnostic imaging , Heart Defects, Congenital/diagnostic imaging , Intellectual Disability/diagnostic imaging , Microcephaly/diagnostic imaging , Muscle Hypotonia/diagnostic imaging , Constriction, Pathologic/diagnostic imaging , Ear Canal/abnormalities , Ear Canal/diagnostic imaging , Humans , Hydrocephalus/diagnostic imaging , Incus/abnormalities , Incus/diagnostic imaging , Infant , Male , Neuroimaging , Retrognathia/diagnostic imaging , Subarachnoid Space/diagnostic imaging , Tomography, X-Ray Computed
14.
J Appl Physiol (1985) ; 126(2): 330-340, 2019 02 01.
Article in English | MEDLINE | ID: mdl-30412031

ABSTRACT

The present study aimed to detail the relationship between the flow and structure characteristics of the upper airways and airway collapsibility in obstructive sleep apnea. Using a computational approach, we performed simulations of the flow and structure of the upper airways in two patients having different facial morphologies: retruding and protruding jaws, respectively. First, transient flow simulation was performed using a prescribed volume flow rate to observe flow characteristics within upper airways with an unsteady effect. In the retruding jaw, the maximum magnitude of velocity and pressure drop with velocity shear and vortical motion was observed at the oropharyngeal level. In contrast, in the protruding jaw, the overall magnitude of velocity and pressure was relatively small. To identify the cause of the pressure drop in the retruding jaw, pressure gradient components induced by flow were examined. Of note, vortical motion was highly associated with pressure drop. Structure simulation was performed to observe the deformation and collapsibility of soft tissue around the upper airways using the surface pressure obtained from the flow simulation. At peak flow rate, the soft tissue of the retruding jaw was highly expanded, and a collapse was observed at the oropharyngeal and epiglottis levels. NEW & NOTEWORTHY Aerodynamic characteristics have been reported to correlate with airway occlusion. However, a detailed mechanism of the phenomenon within the upper airways and its impact on airway collapsibility remain poorly understood. This study provides in silico results for aerodynamic characteristics, such as vortical structure, pressure drop, and exact location of the obstruction using a computational approach. Large deformation of soft tissue was observed in the retruding jaw, suggesting that it is responsible for obstructive sleep apnea.


Subject(s)
Airway Obstruction/physiopathology , Patient-Specific Modeling , Prognathism/physiopathology , Respiratory System/physiopathology , Retrognathia/physiopathology , Sleep Apnea, Obstructive/physiopathology , Airway Obstruction/diagnostic imaging , Airway Obstruction/etiology , Humans , Preliminary Data , Pressure , Prognathism/complications , Prognathism/diagnostic imaging , Respiratory System/diagnostic imaging , Retrognathia/complications , Retrognathia/diagnostic imaging , Risk Factors , Sleep Apnea, Obstructive/diagnosis , Sleep Apnea, Obstructive/etiology , Tomography, X-Ray Computed
15.
Am J Orthod Dentofacial Orthop ; 154(5): 708-717, 2018 Nov.
Article in English | MEDLINE | ID: mdl-30384942

ABSTRACT

A 15-year-old girl with a convex profile and a retrognathic chin was referred for improvement of her profile. Nonextraction orthodontic therapy with temporary skeletal anchorage devices was used to improve her facial balance in a total active treatment time of 26 months. Her occlusion and profile were significantly improved by the treatment. Posttreatment records after 12 months showed excellent results with good occlusion and facial harmony.


Subject(s)
Esthetics, Dental , Facial Asymmetry/pathology , Facial Asymmetry/therapy , Orthodontic Anchorage Procedures , Retrognathia/pathology , Retrognathia/therapy , Adolescent , Cephalometry/methods , Dental Occlusion , Facial Asymmetry/diagnostic imaging , Female , Humans , Radiography , Retrognathia/diagnostic imaging , Treatment Outcome
16.
J Craniomaxillofac Surg ; 46(9): 1470-1475, 2018 Sep.
Article in English | MEDLINE | ID: mdl-30196856

ABSTRACT

The aim of this study was to assess condylar resorption, spatial change in glenoid cavity, and its risk factors after mandibular advancement by three-dimensional volumetric analysis. Subjects consisted of 30 condyles of 15 patients diagnosed with mandibular retrognathism who underwent Le Fort I and bilateral sagittal split ramus osteotomy advancement. CBCT images were taken before surgery (T0), immediately after surgery (T1), and postoperatively at 6 months (T2) and 1 year (T3). Condylar resorption was observed in 21 condyles. The posterior was the most affected region, while the anterior was the least affected. The volume of the glenoid cavity was significantly increased after surgery regardless of the presence or absence of resorption. However, the cavity recovered close to its original volume over time. At 1 year after surgery, the volume was not significantly different from the preoperative volume. Counterclockwise rotation of the proximal segment was found to be a risk factor affecting resorption based on correlation analysis. Mandibular advancement appeared to generate excessive mechanical stress on the posterior condyle, and might be responsible for the resorption. Counterclockwise rotation might have added stress to the region. Articular spatial change was transient and did not appear to be related to condyle resorption.


Subject(s)
Cone-Beam Computed Tomography , Glenoid Cavity/diagnostic imaging , Mandibular Advancement , Mandibular Condyle/diagnostic imaging , Retrognathia/surgery , Adult , Bone Resorption/pathology , Female , Glenoid Cavity/pathology , Humans , Imaging, Three-Dimensional , Male , Mandibular Condyle/pathology , Osteotomy, Le Fort , Osteotomy, Sagittal Split Ramus , Retrognathia/diagnostic imaging , Treatment Outcome
17.
Am J Orthod Dentofacial Orthop ; 154(3): 421-432, 2018 Sep.
Article in English | MEDLINE | ID: mdl-30173846

ABSTRACT

This case report describes the nonsurgical treatment of an adolescent patient with a severe transverse discrepancy presented as a Brodie bite and retrognathic mandible. Distraction osteogenesis has been often used for similar cases in the literature. However, in this patient, a fixed appliance with 1 maxillary extraction combined with a functional appliance was used to resolve the transverse discrepancy with natural growth. After the orthodontic treatment, the impinging teeth and Brodie bite were corrected with a favorable occlusion and profile. Retention at the 3-year follow-up showed improved occlusal interdigitation and good stability.


Subject(s)
Imaging, Three-Dimensional , Malocclusion, Angle Class II/diagnostic imaging , Malocclusion, Angle Class II/therapy , Orthodontic Appliances, Functional , Retrognathia/diagnostic imaging , Retrognathia/therapy , Cephalometry , Child , Cone-Beam Computed Tomography , Humans , Male , Models, Dental , Radiography, Panoramic , Tooth Extraction , Tooth, Supernumerary/surgery
18.
J Plast Reconstr Aesthet Surg ; 71(12): 1786-1795, 2018 Dec.
Article in English | MEDLINE | ID: mdl-30172730

ABSTRACT

BACKGROUND: Maxillary retrognathia is a well-known consequence of abnormal facial growth in patients with cleft lip and palate. Orthognathic surgery improves facial appearance and occlusion but may induce velopharyngeal insufficiency. The aim of this study was to evaluate the effect of orthognathic surgery on velopharyngeal function by using speech analysis and lateral cephalometric radiographs. PATIENTS AND METHODS: We conducted a retrospective study of 47 patients who underwent maxillary advancement ±â€¯mandibular setback between 2006 and 2016. Preoperative and 1 year postoperative audio recordings were blinded for scoring by three trained speech therapists. Preoperative and 1 year postoperative lateral cephalometric radiographs were used to obtain information about skeletal movement and its relationship with the velopharyngeal area. Correlations between speech outcomes and cephalometric radiographs were determined. RESULTS: Hyponasality improved significantly after surgery (p < 0.05), whereas hypernasality deteriorated significantly only in patients who underwent maxillary advancement alone (p < 0.05). No difference in speech parameters was found between patients with hypernasality or patients who had a pharyngoplasty preoperatively and the rest of the group. No correlation was found between the amount of maxillary advancement and hypernasality. A significant correlation (r < -0.49, p < 0.05) was found between the preoperative velar length and hypernasality postoperatively. CONCLUSIONS: Maxillary advancement has a negative impact on velopharyngeal function, whereas bimaxillary surgery seems to protect from deterioration. No difference was found in the amount of maxillary advancement or in velopharyngeal measurements between the Le Fort I group and the bimaxillary group. A short soft palate is a predictor of hypernasality after orthognathic surgery.


Subject(s)
Orthognathic Surgical Procedures/methods , Speech/physiology , Velopharyngeal Insufficiency/physiopathology , Anatomic Landmarks , Cephalometry/methods , Cleft Lip/physiopathology , Cleft Palate/physiopathology , Female , Humans , Male , Malocclusion/diagnostic imaging , Malocclusion/physiopathology , Mandible/diagnostic imaging , Mandible/surgery , Mandibular Advancement/methods , Maxilla/diagnostic imaging , Maxilla/surgery , Osteotomy, Le Fort/methods , Phonetics , Radiography , Retrognathia/diagnostic imaging , Retrognathia/physiopathology , Retrognathia/surgery , Retrospective Studies , Speech Disorders/physiopathology , Speech Disorders/surgery , Young Adult
19.
Br J Oral Maxillofac Surg ; 56(8): 750-752, 2018 10.
Article in English | MEDLINE | ID: mdl-30139703

ABSTRACT

We describe a new approach to the planning of treatment and subsequent operation on a patient with syngnathia and severe mandibular retrognathism. To facilitate a large mandibular advancement we applied alloplastic temporomandibular joint (TMJ) prostheses to the coronoid processes after anticlockwise rotation of the mandible. To the best of our knowledge this is the first documented case of its kind.


Subject(s)
Arthroplasty, Replacement/methods , Mandible/abnormalities , Mandibular Advancement/methods , Maxilla/abnormalities , Micrognathism/surgery , Pierre Robin Syndrome/diagnostic imaging , Pierre Robin Syndrome/surgery , Plastic Surgery Procedures/methods , Retrognathia/surgery , Temporomandibular Joint Disorders/surgery , Humans , Joint Prosthesis , Male , Micrognathism/diagnostic imaging , Retrognathia/diagnostic imaging , Stereolithography , Temporomandibular Joint Disorders/diagnostic imaging , Tomography, X-Ray Computed , Young Adult
20.
Biomed Res Int ; 2018: 2568235, 2018.
Article in English | MEDLINE | ID: mdl-29854734

ABSTRACT

AIM: To assess the three-dimensional (3D) maxillomandibular and dental response to Balters Bionator (BB) and the Sander Bite Jumping Appliance (SBJA) in growing patients. MATERIALS AND METHODS: Twenty-seven Class II division 1 patients (13 males, 14 females), consecutively treated with either the BB (9 females, 7 males; 10.1 ± 1.6 years) or SBJA (5 females, 6 males; 11 ± 1.9 years), were collected from a single orthodontic practice. All patients presented overjet ≥5 mm, full Class II or end-to-end molar relationship, mandibular retrusion. CBCT scans were available at T1 and after removal of the functional appliances (T2) with a mean interval of 18 months. The 3D location and direction of skeletal and dental changes with growth and treatment were quantitatively assessed. Statistical analysis was performed by means of Mann-Whitney U test (p < 0.05). RESULTS: Patients treated with the SBJA and BB orthopedic appliances presented, respectively, 4.7 mm and 4.5 mm of 3D displacement of the chin, with marked ramus growth of, respectively, 3.7 mm and 2.3 mm. While the mandible and maxilla grew downward and forward, no opening of the mandible plane was observed. Both appliances adequately controlled labial inclination of lower incisors (1.3° and 0.3°, for the SBJA and BB groups, resp.). No significant between-group differences were found for the T2-T1 changes for any of the variables, with the exception of molar displacements (significantly greater in the SBJA group than in the BB group, 1.2 mm and 0.9 mm, resp.). CONCLUSIONS: The maxillomandibular and dental growth responses to BB and SBJA therapies are characterized by vertical ramus growth and elongation of mandible that improve the maxillomandibular relationship with adequate control of lower incisor position.


Subject(s)
Bite Force , Jaw Fixation Techniques/instrumentation , Mandible/diagnostic imaging , Retrognathia/diagnostic imaging , Activator Appliances , Adolescent , Child , Dental Occlusion , Female , Humans , Incisor/diagnostic imaging , Incisor/growth & development , Male , Mandible/growth & development , Molar/diagnostic imaging , Molar/growth & development , Retrognathia/physiopathology
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