ABSTRACT
Irradiation of scleromatous lesions produces its effect by destroying the organisms, whereas Streptomycin improves the mucosal defence mechanisms. A combination of both lines of treatment seems to be indicated for the arrest of the pathological process.
Subject(s)
Rhinoscleroma/drug therapy , Streptomycin/therapeutic use , Combined Modality Therapy , Humans , Microscopy, Electron , Nasal Mucosa/ultrastructure , Rhinoscleroma/pathology , Rhinoscleroma/radiotherapyABSTRACT
Nasal biopsies from 2 scleroma patients who had received previous X-ray therapy were investigated under the electron microscope. In the lamina propria, the majority of Mikulicz cells contained numerous small vacuoles. This was attributed to the effect of X-ray therapy causing temporary suppression of the inflammatory process followed by new granuloma formation. The vacuoles of the Mikulicz cells contained some fine granular and fibrillar material of unknown origin. Rounded electron-dense bodies with microprojections on their surface were present near some Mikulicz cells. These structures were considered to be Russell bodies. Occasional small lymph vessels with obstructed lumina were seen. This might indicate the rare spread of Klebsiella rhinoscleromatis bacilli to regional lymph nodes.
Subject(s)
Nasal Mucosa/ultrastructure , Rhinoscleroma/pathology , Adult , Cytoplasm/ultrastructure , Female , Humans , Male , Neoplasm Recurrence, Local , Rhinoscleroma/radiotherapyABSTRACT
The distribution of rhinoscleroma in Asia is reviewed and two cases from Iran are added, a region in which the disease seems not to have been previously reported. The pathogenesis of the disease is reviewed.
