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1.
Turk J Med Sci ; 48(1): 24-27, 2018 Feb 23.
Article in English | MEDLINE | ID: mdl-29479940

ABSTRACT

Background/aim: This study aimed to evaluate traumatic thorax complications in post-CPR patients and to investigate whether or not there has been a decrease in these complications since the adoption of current chest compression recommendations. Materials and methods: Post-CPR patients with return of spontaneous circulation (ROSC) were admitted between January 2014 and January 2016 were analyzed retrospectively. Patients admitted to the ED in 2014 were resuscitated according to 2010 AHA CPR guidelines, while those admitted to the ED in 2015 were resuscitated according to current ERC CPR guidelines. Results: The study population comprised 48 male and 35 female patients. Of the 2010 AHA guideline patients, 39.21% experienced pulmonary contusion, while 54.83% of 2015 ERC guideline patients had pulmonary contusion. It was found that 11.76% of 2010 AHA guideline patients and 3.22% of 2015 ERC guideline patients had pneumothorax, while 9.8% of 2010 AHA guideline patients and 12.9% of 2015 ERC guideline patients experienced hemothorax. Incidence rates of lung contusion, pneumothorax, and hemothorax were higher in patients with rib fractures. Conclusion: In this study, traumatic thoracic complications were investigated in patients with ROSC after CPR. The incidence of CRP-related injuries did not decrease on application of the new 2015 ERC CPR guideline recommendations. The most common injury in this study was rib fracture, followed by sternal fracture, lung contusion, hemothorax, and pneumothorax. Statistically, rib fracture had a positive relationship with lung contusion, hemothorax, and pneumothorax.


Subject(s)
Cardiopulmonary Resuscitation/adverse effects , Contusions , Hemothorax , Pneumothorax , Practice Guidelines as Topic , Rib Fractures , Thoracic Injuries , Aged , Cardiopulmonary Resuscitation/methods , Contusions/epidemiology , Contusions/etiology , Contusions/prevention & control , Female , Hemothorax/epidemiology , Hemothorax/etiology , Hemothorax/prevention & control , Humans , Incidence , Lung , Male , Middle Aged , Pneumothorax/epidemiology , Pneumothorax/etiology , Pneumothorax/prevention & control , Retrospective Studies , Rib Fractures/epidemiology , Rib Fractures/etiology , Rib Fractures/prevention & control , Ribs , Risk Factors , Sternum , Thoracic Injuries/epidemiology , Thoracic Injuries/etiology , Thoracic Injuries/prevention & control
2.
Accid Anal Prev ; 95(Pt A): 42-56, 2016 Oct.
Article in English | MEDLINE | ID: mdl-27393912

ABSTRACT

OBJECTIVE: Frontal crashes still account for approximately half of all fatalities in passenger cars, despite several decades of crash-related research. For serious injuries in this crash mode, several authors have listed the thorax as the most important. Computer simulation provides an effective tool to study crashes and evaluate injury mechanisms, and using stochastic input data, whole populations of crashes can be studied. The aim of this study was to develop a generic buck model and to validate this model on a population of real-life frontal crashes in terms of the risk of rib fracture. METHOD: The study was conducted in four phases. In the first phase, real-life validation data were derived by analyzing NASS/CDS data to find the relationship between injury risk and crash parameters. In addition, available statistical distributions for the parameters were collected. In the second phase, a generic parameterized finite element (FE) model of a vehicle interior was developed based on laser scans from the A2MAC1 database. In the third phase, model parameters that could not be found in the literature were estimated using reverse engineering based on NCAP tests. Finally, in the fourth phase, the stochastic FE model was used to simulate a population of real-life crashes, and the result was compared to the validation data from phase one. RESULTS: The stochastic FE simulation model overestimates the risk of rib fracture, more for young occupants and less for senior occupants. However, if the effect of underestimation of rib fractures in the NASS/CDS material is accounted for using statistical simulations, the risk of rib fracture based on the stochastic FE model matches the risk based on the NASS/CDS data for senior occupants. CONCLUSION: The current version of the stochastic model can be used to evaluate new safety measures using a population of frontal crashes for senior occupants.


Subject(s)
Accidents, Traffic/statistics & numerical data , Computer Simulation , Finite Element Analysis , Rib Fractures/etiology , Rib Fractures/prevention & control , Databases, Factual , Humans , Models, Statistical , Rib Fractures/epidemiology , Risk Assessment/statistics & numerical data , Safety , Stochastic Processes
3.
Semin Radiat Oncol ; 26(2): 129-34, 2016 Apr.
Article in English | MEDLINE | ID: mdl-27000509

ABSTRACT

Many recent studies have described rib fractures and chest wall pain following stereotactic body radiation therapy (SBRT). Although these toxicities generally are not life-threatening, the chest wall and ribs are considered dose-limiting tissues because of the potential effect on patients׳ quality of life. Few studies have reported dose-response models that can provide quantitative estimates of risk as a function of dose and volume. Notably, Memorial Sloan Kettering Cancer Center (Mutter et al(8)) analyzed grade 2 or higher chest wall toxicity in a cohort of 126 patients treated with linear accelerator-based SBRT; the authors provided detailed dose-volume histogram (DVH) data to allow for pooled analyses. We pooled these 126 patients with an additional 44 patients treated with CyberKnife at the Erlanger Medical Center to create an updated dose-response model for chest wall tolerance. In the aggregate analysis, the 10% risk level for grade 2 or higher complications for D70cc was 16.2Gy in 4 fractions, and the 50% risk level was D70cc = 65.1Gy in 4 fractions. For D2cc, the 10% and 50% risk levels in 4 fractions were 43.0Gy and 87.9Gy, respectively. These dose-tolerance limits may help quantify chest wall toxicity risks. Further research continues to determine more accurate estimates of grade 3 risk levels.


Subject(s)
Lung Neoplasms/radiotherapy , Radiation Injuries/prevention & control , Radiation Tolerance , Radiosurgery/methods , Dose-Response Relationship, Radiation , Humans , Models, Theoretical , Radiotherapy Dosage , Rib Fractures/prevention & control
4.
Radiother Oncol ; 118(3): 528-34, 2016 Mar.
Article in English | MEDLINE | ID: mdl-26743835

ABSTRACT

BACKGROUND AND PURPOSE: Determination of a dose-effect relation for rib fractures in a large patient group has been limited by the time consuming manual delineation of ribs. Automatic segmentation could facilitate such an analysis. We determine the accuracy of automatic rib segmentation in the context of normal tissue complication probability modeling (NTCP). MATERIALS AND METHODS: Forty-one patients with stage I/II non-small cell lung cancer treated with SBRT to 54 Gy in 3 fractions were selected. Using the 4DCT derived mid-ventilation planning CT, all ribs were manually contoured and automatically segmented. Accuracy of segmentation was assessed using volumetric, shape and dosimetric measures. Manual and automatic dosimetric parameters Dx and EUD were tested for equivalence using the Two One-Sided T-test (TOST), and assessed for agreement using Bland-Altman analysis. NTCP models based on manual and automatic segmentation were compared. RESULTS: Automatic segmentation was comparable with the manual delineation in radial direction, but larger near the costal cartilage and vertebrae. Manual and automatic Dx and EUD were significantly equivalent. The Bland-Altman analysis showed good agreement. The two NTCP models were very similar. CONCLUSIONS: Automatic rib segmentation was significantly equivalent to manual delineation and can be used for NTCP modeling in a large patient group.


Subject(s)
Carcinoma, Non-Small-Cell Lung/radiotherapy , Lung Neoplasms/radiotherapy , Models, Statistical , Radiotherapy Planning, Computer-Assisted/methods , Ribs/radiation effects , Aged , Automation , Carcinoma, Non-Small-Cell Lung/diagnostic imaging , Dose-Response Relationship, Radiation , Female , Four-Dimensional Computed Tomography , Humans , Lung Neoplasms/diagnostic imaging , Male , Neoplasm Staging , Probability , Radiation Injuries/etiology , Radiation Injuries/prevention & control , Respiratory Mechanics , Rib Fractures/etiology , Rib Fractures/prevention & control , Ribs/pathology
5.
Accid Anal Prev ; 85: 73-82, 2015 Dec.
Article in English | MEDLINE | ID: mdl-26397197

ABSTRACT

There is a need to improve the protection to the thorax of occupants in frontal car crashes. Finite element human body models are a more detailed representation of humans than anthropomorphic test devices (ATDs). On the other hand, there is no clear consensus on the injury criteria and the thresholds to use with finite element human body models to predict rib fractures. The objective of this study was to establish a set of injury risk curves to predict rib fractures using a modified Total HUman Model for Safety (THUMS). Injury criteria at the global, structural and material levels were computed with a modified THUMS in matched Post Mortem Human Subjects (PMHSs) tests. Finally, the quality of each injury risk curve was determined. For the included PMHS tests and the modified THUMS, DcTHOR and shear stress were the criteria at the global and material levels that reached an acceptable quality. The injury risk curves at the structural level did not reach an acceptable quality.


Subject(s)
Accidents, Traffic/prevention & control , Accidents, Traffic/statistics & numerical data , Human Body , Rib Fractures/prevention & control , Safety Management/methods , Adult , Female , Humans , Male , Middle Aged , Models, Biological , Motor Vehicles , Risk Assessment , Seat Belts , Stress, Mechanical
6.
Med Biol Eng Comput ; 53(6): 487-97, 2015 Jun.
Article in English | MEDLINE | ID: mdl-25735437

ABSTRACT

Chest compression (CC) is a significant emergency medical procedure for maintaining circulation during cardiac arrest. Although CC produces the necessary blood flow for patients with heart arrest, improperly deep CC will contribute significantly to the risk of chest injury. In this paper, an optimal CC closed-loop controller for a mechanical chest compressor (OCC-MCC) was developed to provide an effective trade-off between the benefit of improved blood perfusion and the risk of ribs fracture. The trade-off performance of the OCC-MCC during real automatic mechanical CCs was evaluated by comparing the OCC-MCC and the traditional mechanical CC method (TMCM) with a human circulation hardware model based on hardware simulations. A benefit factor (BF), risk factor (RF) and benefit versus risk index (BRI) were introduced in this paper for the comprehensive evaluation of risk and benefit. The OCC-MCC was developed using the LabVIEW control platform and the mechanical chest compressor (MCC) controller. PID control is also employed by MCC for effective compression depth regulation. In addition, the physiological parameters model for MCC was built based on a digital signal processor for hardware simulations. A comparison between the OCC-MCC and TMCM was then performed based on the simulation test platform which is composed of the MCC, LabVIEW control platform, physiological parameters model for MCC and the manikin. Compared with the TMCM, the OCC-MCC obtained a better trade-off and a higher BRI in seven out of a total of nine cases. With a higher mean value of cardiac output (1.35 L/min) and partial pressure of end-tidal CO2 (15.7 mmHg), the OCC-MCC obtained a larger blood flow and higher BF than TMCM (5.19 vs. 3.41) in six out of a total of nine cases. Although it is relatively difficult to maintain a stable CC depth when the chest is stiff, the OCC-MCC is still superior to the TMCM for performing safe and effective CC during CPR. The OCC-MCC is superior to the TMCM in performing safe and effective CC during CPR and can be incorporated into the current version of mechanical CC devices for high quality CPR, in both in-hospital and out-of-hospital CPR settings.


Subject(s)
Blood Circulation/physiology , Cardiopulmonary Resuscitation/instrumentation , Models, Cardiovascular , Rib Fractures/prevention & control , Signal Processing, Computer-Assisted/instrumentation , Adult , Cardiopulmonary Resuscitation/adverse effects , Humans , Partial Pressure , Tidal Volume
7.
Thorac Cardiovasc Surg ; 62(8): 728-9, 2014 Dec.
Article in English | MEDLINE | ID: mdl-24911899

ABSTRACT

This article describes an alternative suture technique for thoracotomy incisions. A modified mattress suture technique is used to fix the intercostal muscles. The described technique can prevent rib fractures and reduce the incidence of intercostal nerve injury. Also, this technique is easy to perform and is effective.


Subject(s)
Intercostal Muscles/surgery , Intercostal Nerves/injuries , Peripheral Nerve Injuries/prevention & control , Rib Fractures/prevention & control , Suture Techniques , Thoracostomy/methods , Adult , Aged , Aged, 80 and over , Humans , Intercostal Muscles/innervation , Middle Aged , Pain, Postoperative/etiology , Pain, Postoperative/prevention & control , Peripheral Nerve Injuries/etiology , Rib Fractures/etiology , Suture Techniques/adverse effects , Thoracostomy/adverse effects , Treatment Outcome
8.
Traffic Inj Prev ; 15(1): 48-55, 2014.
Article in English | MEDLINE | ID: mdl-24279966

ABSTRACT

OBJECTIVE: In vehicle frontal impacts, vehicle acceleration has a large effect on occupant loadings and injury risks. In this research, an optimal vehicle crash pulse was determined systematically to reduce injury measures of rear seat occupants by using mathematical simulations. METHOD: The vehicle crash pulse was optimized based on a vehicle deceleration-deformation diagram under the conditions that the initial velocity and the maximum vehicle deformation were constant. Initially, a spring-mass model was used to understand the fundamental parameters for optimization. In order to investigate the optimization under a more realistic situation, the vehicle crash pulse was also optimized using a multibody model of a Hybrid III dummy seated in the rear seat for the objective functions of chest acceleration and chest deflection. A sled test using a Hybrid III dummy was carried out to confirm the simulation results. Finally, the optimal crash pulses determined from the multibody simulation were applied to a human finite element (FE) model. RESULTS: The optimized crash pulse to minimize the occupant deceleration had a concave shape: a high deceleration in the initial phase, low in the middle phase, and high again in the final phase. This crash pulse shape depended on the occupant restraint stiffness. The optimized crash pulse determined from the multibody simulation was comparable to that from the spring-mass model. From the sled test, it was demonstrated that the optimized crash pulse was effective for the reduction of chest acceleration. The crash pulse was also optimized for the objective function of chest deflection. The optimized crash pulse in the final phase was lower than that obtained for the minimization of chest acceleration. In the FE analysis of the human FE model, the optimized pulse for the objective function of the Hybrid III chest deflection was effective in reducing rib fracture risks. CONCLUSIONS: The optimized crash pulse has a concave shape and is dependent on the occupant restraint stiffness and maximum vehicle deformation. The shapes of the optimized crash pulse in the final phase were different for the objective functions of chest acceleration and chest deflection due to the inertial forces of the head and upper extremities. From the human FE model analysis it was found that the optimized crash pulse for the Hybrid III chest deflection can substantially reduce the risk of rib cage fractures. Supplemental materials are available for this article. Go to the publisher's online edition of Traffic Injury Prevention to view the supplemental file.


Subject(s)
Accidents, Traffic/statistics & numerical data , Deceleration , Rib Fractures/prevention & control , Thorax/physiology , Biomechanical Phenomena , Computer Simulation , Finite Element Analysis , Humans , Manikins , Risk
9.
Accid Anal Prev ; 62: 248-58, 2014 Jan.
Article in English | MEDLINE | ID: mdl-24200907

ABSTRACT

In many countries increased on-road motorcycling participation has contributed to increased motorcyclist morbidity and mortality over recent decades. Improved helmet technologies and increased helmet wearing rates have contributed to reductions in serious head injuries, to the point where in many regions thoracic injury is now the most frequently occurring serious injury. However, few advances have been made in reducing the severity of motorcyclist thoracic injury. The aim of the present study is to provide needed information regarding serious motorcyclist thoracic trauma, to assist motorcycling groups, road safety advocates and road authorities develop and prioritise counter-measures and ultimately reduce the rising trauma burden. For this purpose, a data collection of linked police-reported and hospital data was established, and considerable attention was given to establishing a weighting procedure to estimate hospital cases not reported to police and fatal cases not admitted to hospital. The resulting data collection of an estimated 19,979 hospitalised motorcyclists is used to provide detailed information on the nature, incidence and risk factors for thoracic trauma. Over the last decade the incidence of motorcyclist serious thoracic injury has more than doubled in the population considered, and by 2011 while motorcycles comprised 3.2% of the registered vehicle fleet, one quarter of road traffic-related serious thoracic trauma cases treated in hospitals were motorcyclists. Motor-vehicle collisions, fixed object collisions and non-collision crashes were fairly evenly represented amongst these cases, while older motorcyclists were over-represented. Several prevention strategies are identified and discussed.


Subject(s)
Accidents, Traffic/statistics & numerical data , Automobile Driving/statistics & numerical data , Motorcycles/statistics & numerical data , Thoracic Injuries/epidemiology , Trauma Severity Indices , Accidents, Traffic/prevention & control , Adult , Female , Flail Chest/epidemiology , Flail Chest/prevention & control , Head Protective Devices/statistics & numerical data , Hemopneumothorax/epidemiology , Hemopneumothorax/prevention & control , Hemothorax/epidemiology , Hemothorax/prevention & control , Humans , Lung Injury/epidemiology , Lung Injury/prevention & control , Male , Middle Aged , New South Wales/epidemiology , Pneumothorax/epidemiology , Pneumothorax/prevention & control , Rib Fractures/epidemiology , Rib Fractures/prevention & control , Risk Factors , Thoracic Injuries/prevention & control , Young Adult
10.
Gesundheitswesen ; 74(10): e90-8, 2012 Oct.
Article in German | MEDLINE | ID: mdl-22422076

ABSTRACT

OBJECTIVES: We examined the financial burden of osteoporosis in Austria. METHODS: We took both direct and indirect costs into consideration. Direct costs encompass medical costs such as expenses for pharmaceuticals, inpatient and outpatient medical care costs, as well as other medical services (e.g., occupational therapies). Non-medical direct costs include transportation costs and medical devices (e.g., wheel chairs or crutches). Indirect costs refer to costs of productivity losses due to absence of work. Moreover, we included costs for early retirement and opportunity costs of informal care provided by family members. While there exist similar studies for other countries, this is the first comprehensive study for Austria. For our analysis, we combined data of official statistics, expert estimates as well as unique patient surveys that are currently conducted in the course of an international osteoporotic fracture study in Austria. RESULTS: Our estimation of the total annual costs in the year 2008 imposed by osteoporosis in Austria is 707.4 million €. The largest fraction of this amount is incurred by acute hospital treatment. Another significant figure, accounting for 29% of total costs, is the opportunity cost of informal care. CONCLUSIONS: The financial burden of osteoporosis in Austria is substantial. Economic evaluations of preventive and therapeutic interventions for the specific context of Austria are needed to inform health policy decision makers.


Subject(s)
Health Care Costs/statistics & numerical data , Hospitalization/economics , National Health Programs/economics , Osteoporotic Fractures/economics , Patient Care/economics , Ambulatory Care/economics , Austria , Caregivers/economics , Costs and Cost Analysis , Drug Costs/statistics & numerical data , Female , Forearm Injuries/economics , Forearm Injuries/prevention & control , Health Policy/economics , Hip Fractures/economics , Hip Fractures/prevention & control , Home Care Services/economics , Home Nursing/economics , Humans , Humeral Fractures/economics , Humeral Fractures/prevention & control , Length of Stay/economics , Male , Osteoporotic Fractures/prevention & control , Pensions/statistics & numerical data , Rib Fractures/economics , Rib Fractures/prevention & control , Spinal Fractures/economics , Spinal Fractures/prevention & control
11.
Sports Med ; 41(11): 883-901, 2011 Nov 01.
Article in English | MEDLINE | ID: mdl-21985212

ABSTRACT

Rib stress fractures (RSFs) can have serious effects on rowing training and performance and accordingly represent an important topic for sports medicine practitioners. Therefore, the aim of this review is to outline the definition, epidemiology, mechanisms, intrinsic and extrinsic risk factors, injury management and injury prevention strategies for RSF in rowers. To this end, nine relevant books, 140 journal articles, the proceedings of five conferences and two unpublished presentations were reviewed after searches of electronic databases using the keywords 'rowing', 'rib', 'stress fracture', 'injury', 'mechanics' and 'kinetics'. The review showed that RSF is an incomplete fracture occurring from an imbalance between the rate of bone resorption and the rate of bone formation. RSF occurs in 8.1-16.4% of elite rowers, 2% of university rowers and 1% of junior elite rowers. Approximately 86% of rowing RSF cases with known locations occur in ribs four to eight, mostly along the anterolateral/lateral rib cage. Elite rowers are more likely to experience RSF than nonelite rowers. Injury occurrence is equal among sweep rowers and scullers, but the regional location of the injury differs. The mechanism of injury is multifactorial with numerous intrinsic and extrinsic risk factors contributing. Posterior-directed resultant forces arising from the forward directed force vector through the arms to the oar handle in combination with the force vector induced by the scapula retractors during mid-drive, or repetitive stress from the external obliques and rectus abdominis in the 'finish' position, may be responsible for RSF. Joint hypomobility, vertebral malalignment or low bone mineral density may be associated with RSF. Case studies have shown increased risk associated with amenorrhoea, low bone density or poor technique, in combination with increases in training volume. Training volume alone may have less effect on injury than other factors. Large differences in seat and handle velocity, sequential movement patterns, higher elbow-flexion to knee-extension strength ratios, higher seat-to-handle velocity during the initial drive, or higher shoulder angle excursion may result in RSF. Gearing may indirectly affect rib loading. Increased risk may be due to low calcium, low vitamin D, eating disorders, low testosterone or use of depot medroxyprogesterone injections. Injury management involves 1-2 weeks cessation of rowing with analgesic modalities followed by a slow return to rowing with low-impact intensity and modified pain-free training. Some evidence shows injury prevention strategies should focus on strengthening the serratus anterior, strengthening leg extensors, stretching the lumbar spine, increasing hip joint flexibility, reducing excessive protraction, training with ergometers on slides or floating-head ergometers, and calcium and vitamin D supplementation. Future research should focus on the epidemiology of RSF over 4-year Olympic cycles in elite rowers, the aetiology of the condition, and the effectiveness of RSF prevention strategies for injury incidence and performance in rowing.


Subject(s)
Athletic Injuries/etiology , Athletic Injuries/prevention & control , Fractures, Stress/etiology , Fractures, Stress/prevention & control , Rib Fractures/etiology , Rib Fractures/prevention & control , Athletic Injuries/epidemiology , Athletic Injuries/physiopathology , Fractures, Stress/epidemiology , Fractures, Stress/physiopathology , Humans , Incidence , Posture/physiology , Rib Fractures/epidemiology , Rib Fractures/physiopathology , Risk Factors
12.
Ann Biomed Eng ; 39(8): 2141-51, 2011 Aug.
Article in English | MEDLINE | ID: mdl-21512892

ABSTRACT

The purpose of this study was to quantify the biomechanical response of the human thorax during dynamic shoulder belt loading representative of that seen in a severe automotive collision. Two post-mortem human surrogates (PMHSs) (one male and one female) were instrumented with 26 single-axis strain gages on the ribs, sternum, and clavicle. The thorax of each PMHS was placed on a custom spine support bracket designed to support the thorax on either side of the spinous process, thereby allowing free motion at the costovertebral joints. In addition, the support bracket raised the thorax above the flat base plate, which could otherwise constrain the deformation and motion of the posterior region of the rib cage. The thorax of each PMHS was then loaded using a custom table-top belt loading system that generated thoracic displacement rates representative of a severe automotive collision, 1.3 m/s for the male PMHS and 1.0 m/s for the female PMHS. The rib fracture timing data, determined by analyzing the strain gage time histories, showed that severe thoracic injury (AIS = 3) occurred at 16% chest compression for the male and 12% chest compression for the female. However, these values are well below the current thoracic injury criteria of 29% chest compression for the male and 23% chest compression for the female. This data illustrates that serious thoracic injury (AIS = 3) occurs at lower chest compressions than the current ATD thoracic injury criteria. Overall, this study provides critical data that can be used in the design and validation of advanced ATDs and finite element models, as well as the establishment of improved, more stringent thoracic injury criteria.


Subject(s)
Accidents, Traffic , Rib Fractures/pathology , Rib Fractures/prevention & control , Seat Belts , Thoracic Injuries/pathology , Thoracic Injuries/prevention & control , Aged , Female , Humans , Male , Time Factors , Trauma Severity Indices
13.
Accid Anal Prev ; 43(3): 661-5, 2011 May.
Article in English | MEDLINE | ID: mdl-21376852

ABSTRACT

As the population ages, the need to protect the elderly during motor vehicle crashes becomes increasingly critical. This study focuses on causation of elderly rib and sternum fractures in seriously injured elderly occupants involved in motor vehicle crashes. We used data from the Crash Injury Research and Engineering Network (CIREN) database (1997-2009). Study case criteria included occupant (≥ 65 years old) drivers (sitting in the left outboard position of the first row) or passengers (sitting in the first row right outboard position) who were in frontal or side impacts. To avoid selection bias, only occupants with a Maximum Abbreviated Injury Scale (MAIS) 3 (serious) or greater severity injury were included in this study. Odds ratios were used as a descriptive measure of the strength of association between variables and Chi square tests were used to determine if there was a statistically significant relationship between categorical variables. Of the 211 elderly (65-79 years old) occupants with thoracic injury, 92.0% had rib fractures and 19.6% had sternum fractures. For the 76 extreme elderly (80 years or older) with thoracic injury, 90.4% had rib fractures and 27.7% had sternum fractures. Except for greater mortality and more rib fractures caused by safety belts, there were no differences between the extreme elderly and the elderly occupants. Current safety systems may need to be redesigned to prevent rib and sternum fractures in occupants 80 years and older.


Subject(s)
Accidents, Traffic/statistics & numerical data , Fractures, Bone/epidemiology , Frail Elderly , Rib Fractures/epidemiology , Sternum/injuries , Thoracic Injuries/epidemiology , Accidents, Traffic/prevention & control , Age Factors , Aged , Aged, 80 and over , Cross-Sectional Studies , Databases, Factual , Female , Fractures, Bone/prevention & control , Humans , Incidence , Injury Severity Score , Male , Rib Fractures/prevention & control , Risk Factors , Seat Belts/adverse effects , Seat Belts/statistics & numerical data , Thoracic Injuries/prevention & control , United States
14.
BMC Cardiovasc Disord ; 10: 53, 2010 Oct 28.
Article in English | MEDLINE | ID: mdl-21029406

ABSTRACT

BACKGROUND: Optimal manual closed chest compressions are difficult to give. A mechanical compression/decompression device, named LUCAS, is programmed to give compression according to the latest international guidelines (2005) for cardiopulmonary resuscitation (CPR). The aim of the present study was to compare manual CPR with LUCAS-CPR. METHODS: 30 kg pigs were anesthetized and intubated. After a base-line period and five minutes of ventricular fibrillation, manual CPR (n = 8) or LUCAS-CPR (n = 8) was started and run for 20 minutes. Professional paramedics gave manual chest compression's alternating in 2-minute periods. Ventilation, one breath for each 10 compressions, was given to all animals. Defibrillation and, if needed, adrenaline were given to obtain a return of spontaneous circulation (ROSC). RESULTS: The mean coronary perfusion pressure was significantly (p < 0.01) higher in the mechanical group, around 20 mmHg, compared to around 5 mmHg in the manual group. In the manual group 54 rib fractures occurred compared to 33 in the LUCAS group (p < 0.01). In the manual group one severe liver injury and one pressure pneumothorax were also seen. All 8 pigs in the mechanical group achieved ROSC, as compared with 3 pigs in the manual group. CONCLUSIONS: LUCAS-CPR gave significantly higher coronary perfusion pressure and significantly fewer rib fractures than manual CPR in this porcine model.


Subject(s)
Cardiopulmonary Resuscitation/instrumentation , Defibrillators/statistics & numerical data , Musculoskeletal Manipulations/adverse effects , Ventricular Fibrillation/therapy , Animals , Blood Pressure Determination , Cardiopulmonary Resuscitation/adverse effects , Cardiopulmonary Resuscitation/methods , Disease Models, Animal , Humans , Musculoskeletal Manipulations/methods , Practice Guidelines as Topic , Recovery of Function , Rib Fractures/etiology , Rib Fractures/prevention & control , Swine , Ventricular Fibrillation/physiopathology
15.
Dig Dis Sci ; 55(4): 947-51, 2010 Apr.
Article in English | MEDLINE | ID: mdl-19731032

ABSTRACT

BACKGROUND The endoscopy unit before remediation may be a high-risk area for slip and fall injuries due to a large number of exposed above-the-floor wires in the endoscopy rooms, dimmed lighting during endoscopic procedures, and staff inattention to obstacles due to preoccupation with the endoscopic patient. AIM To describe a novel, previously unappreciated workplace hazard to endoscopic personnel: Exposed wires in the endoscopy unit.METHODS This study is a retrospective review of 110,000 endoscopic procedures performed during the last 5 years at an academic, teaching hospital with a high-volume endoscopy unit. All significant orthopedic injuries to endoscopic personnel from slips, twists, and falls from tripping over exposed cords in the endoscopy unit were reviewed. The severity of injury was documented based on roentgenographic findings, number of days of missed work, number of days with a modified work schedule, and requirement for orthopedic surgery. The number of potentially exposed cords per endoscopy room was determined. RESULTS During the 5-year study period, three endoscopic personnel suffered significant orthopedic injuries from slips, twists, and falls from tripping over cords, wires, or tubing lying exposed over the floor in the endoscopy suite: The resulting injuries consisted of fourth and fifth metacarpal hand fractures due to a fall after tripping on oxygen tubing; a rib fracture due to tripping on electrical wires trailing from an endoscopy cart; and a grade II ankle sprain due to the foot becoming entangled in oxygen tubing. All injuries resulted in lost days of work [mean 9.3 +/- 11.0 (SD) days] and in additional days of restricted work (mean 41.7 +/- 31.8 days). One injury required orthopedic surgery. Hospital review revealed a mean of 35.3 +/- 7.5 cords, wires, or tubing per endoscopy procedure room, the majority of which were exposed above the floor before remediation (n = 10 rooms). Remediation of exposed wires included: bundling related wires together in a cable to reduce the number of independent wires, covering exposed wires on the floor with a nonslip heavy mat, and running wires from ceiling outlets to equipment high above ground (e.g. mounted endoscopy video monitors). CONCLUSIONS Tripping, slipping, and falling over exposed wires can cause significant injury to endoscopic personnel. This previously undescribed hazard should be preventable by simple remediation, and all endoscopic personnel, hospital architects, hospital administrators, and governmental regulators should be alerted to this potential hazard


Subject(s)
Accidental Falls/prevention & control , Accidents, Occupational/prevention & control , Electric Wiring , Endoscopy, Gastrointestinal , Fractures, Bone/prevention & control , Personnel, Hospital/statistics & numerical data , Sprains and Strains/prevention & control , Academic Medical Centers/statistics & numerical data , Accidental Falls/statistics & numerical data , Accidents, Occupational/statistics & numerical data , Adult , Ankle Injuries/epidemiology , Ankle Injuries/prevention & control , Ankle Injuries/surgery , Cross-Sectional Studies , Female , Fractures, Bone/epidemiology , Fractures, Bone/surgery , Fractures, Comminuted/epidemiology , Fractures, Comminuted/prevention & control , Fractures, Comminuted/surgery , Hand Injuries/epidemiology , Hand Injuries/prevention & control , Hand Injuries/surgery , Humans , Lighting , Male , Metacarpal Bones/injuries , Middle Aged , Nursing Staff, Hospital , Orthopedic Procedures/statistics & numerical data , Retrospective Studies , Rib Fractures/epidemiology , Rib Fractures/prevention & control , Rib Fractures/surgery , Safety Management , Sick Leave/statistics & numerical data , Sprains and Strains/epidemiology , Sprains and Strains/surgery , United States , United States Occupational Safety and Health Administration
16.
Science ; 311(5767): 1621-3, 2006 Mar 17.
Article in English | MEDLINE | ID: mdl-16484451

ABSTRACT

Progerias are rare genetic diseases characterized by premature aging. Several progeroid disorders are caused by mutations that lead to the accumulation of a lipid-modified (farnesylated) form of prelamin A, a protein that contributes to the structural scaffolding for the cell nucleus. In progeria, the accumulation of farnesyl-prelamin A disrupts this scaffolding, leading to misshapen nuclei. Previous studies have shown that farnesyltransferase inhibitors (FTIs) reverse this cellular abnormality. We tested the efficacy of an FTI (ABT-100) in Zmpste24-deficient mice, a mouse model of progeria. The FTI-treated mice exhibited improved body weight, grip strength, bone integrity, and percent survival at 20 weeks of age. These results suggest that FTIs may have beneficial effects in humans with progeria.


Subject(s)
Enzyme Inhibitors/therapeutic use , Farnesyltranstransferase/antagonists & inhibitors , Imidazoles/therapeutic use , Progeria/drug therapy , Animals , Body Weight/drug effects , Disease Models, Animal , Enzyme Inhibitors/pharmacology , Female , Hand Strength , Imidazoles/pharmacology , Lamin Type A , Male , Membrane Proteins/deficiency , Membrane Proteins/genetics , Metalloendopeptidases/deficiency , Metalloendopeptidases/genetics , Mice , Nuclear Proteins/metabolism , Progeria/physiopathology , Protein Precursors/metabolism , Protein Prenylation/drug effects , Rib Fractures/prevention & control , Survival Rate
17.
Article in English | MEDLINE | ID: mdl-11558086

ABSTRACT

This paper presents a study of the rib fracture patterns generated in simulated frontal collisions and the visibility of the rib fractures on plain film radiographs. Using 29 cadaver subjects, rib fractures were identified on oblique, lateral, and anteroposterior chest films by five radiologists independently and were compared with fractures found during a detailed necropsy. Physical, geometric, and experimental factors demonstrated an influence on the ability of a radiologist to identify rib fractures on an x-ray. Specifically, the restraint system configuration, the total number of fractures, the circumferential location of the fracture, the rib number, and the aspect (right or left) affected fracture identification. The results verify that torso belt loading produces rib fractures generally located along the path of the belt whereas superimposed airbag loading results in a more distributed and posterolateral fracture pattern. A higher proportion of rib fractures was identified on x-ray for occupants restrained by only a belt (44% of fractures) than for occupants restrained by both a belt and an airbag (24% of fractures). Overall, less than 40% of the rib fractures were detected upon an initial examination of radiographs. After being provided with the location of all fractures, detection increased to 49%. On average, occult rib fractures resulted in an average underreporting of injury severity of more than one AIS level.


Subject(s)
Accidents, Traffic , Air Bags , Rib Fractures/diagnostic imaging , Seat Belts , Acceleration , Adult , Aged , Biomechanical Phenomena , Female , Humans , Male , Middle Aged , Radiography , Rib Fractures/etiology , Rib Fractures/prevention & control , Sensitivity and Specificity
18.
Article in English | MEDLINE | ID: mdl-11558087

ABSTRACT

Restrained driver and right-front passenger kinematics and injury outcome in frontal collisions are compared using FARS data and human cadaver sled tests. The FARS data indicate that a frontal airbag may provide greater benefit for a passenger than for a driver. The thoracic injuries sustained by passenger subjects restrained by a force-limited, pretensioned belt and airbag are evaluated, and kinematics are compared to driver-side subjects. The injury-predictive ability of existing thoracic injury criteria is evaluated for passenger-side occupants. Driver and passenger kinematic differences are identified and the implications are discussed. The chest acceleration of the passenger-side subjects exhibited a bimodal profile with an initial (and global) maximum before the subject loaded the airbag. A second acceleration peak occurred as the subject loaded both the belt and the airbag. A similarly restrained driver-side subject loaded the belt and airbag concurrently at the time of peak chest acceleration and therefore did not exhibit this bimodal chest acceleration.


Subject(s)
Accidents, Traffic , Air Bags , Seat Belts , Thoracic Injuries/etiology , Acceleration , Aged , Biomechanical Phenomena , Female , Humans , Male , Middle Aged , Rib Fractures/etiology , Rib Fractures/prevention & control , Risk Assessment , Thoracic Injuries/prevention & control
19.
Am J Sports Med ; 26(4): 516-9, 1998.
Article in English | MEDLINE | ID: mdl-9689370

ABSTRACT

The potential cause of stress fractures of the rib in elite rowers was examined by a retrospective review of 14 fractures in 10 patients. Fractures occurred on the antero- to posterolateral aspects of ribs 5 through 9 and were most often associated with long-distance training and heavy load per stroke. A review of the literature yields striking similarities between these stress fractures and fractures caused by cough. It is suggested that actions of the serratus anterior and external oblique muscles on the rib cause stress fracture because of the repetitive bending forces in both rowing and coughing. A technique involving less use of both muscles through a truncated arm pull-through and a decreased layback position at the end of the stroke, and equipment changes to decrease length of the lever arm, should yield a decreased risk of rib stress fractures in rowing.


Subject(s)
Athletic Injuries/etiology , Fractures, Stress/etiology , Rib Fractures/etiology , Arm/physiopathology , Athletic Injuries/prevention & control , Cough/complications , Cough/physiopathology , Cumulative Trauma Disorders/complications , Cumulative Trauma Disorders/physiopathology , Female , Fractures, Stress/prevention & control , Humans , Male , Muscle Contraction/physiology , Muscle, Skeletal/physiopathology , Physical Education and Training , Posture/physiology , Retrospective Studies , Rib Fractures/classification , Rib Fractures/prevention & control , Risk Factors , Sports Equipment/adverse effects , Thorax/physiopathology , Weight-Bearing
20.
Resuscitation ; 35(3): 259-63, 1997 Nov.
Article in English | MEDLINE | ID: mdl-10203407

ABSTRACT

According to most published guidelines of cardiopulmonary resuscitation chest compression is performed on the lower half of the sternum by compressing the sternum with the heel of one hand and the other hand on top of the first. In all guidelines and during CPR training great importance is attributed to exact localisation of the so-called compression point. In a laboratory investigation we assessed the force distribution across the heel of the hand and defined the total breadth in contact with the sternum. In order to find out whether there is any difference in the force pattern with the right or the left hand in direct contact with the sternum we determined the resultant maximal force of that part of the heel of the hand exerting the maximal force. A total of 12 anaesthetists performed simulated chest compressions onto a flat surface covered with an integrated force sensor mat. The distance between the most ulnar part and the most radial part of the hand was determined to be 9.2 cm. Similar mean total forces were measured (right hand in contact: 644 N; left hand in contact: 621 N). In all except one anaesthetist the hypothenar part of the heel exerted a significantly higher force compared to the thenar part, independent of whether the right hand or the left hand was in contact. The distance between points of maximal force when the right hand or when the left hand in contact was 2.2 cm corresponding to the breadth of one and a half fingers. To reduce the potential risk of sternal fractures by chest compressions applied too far in a cephalad direction, we recommend use of the right hand in contact if the rescuer kneels at the right side of the patient and vice versa.


Subject(s)
Hand/physiology , Heart Massage , Adult , Cardiopulmonary Resuscitation , Female , Fractures, Bone/prevention & control , Functional Laterality , Hand/anatomy & histology , Humans , Male , Pressure , Rib Fractures/prevention & control , Risk Factors , Sternum/injuries , Sternum/physiology , Stress, Mechanical , Thorax/physiology
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