ABSTRACT
Results of long-term prospective follow-up of patients with early stages of mitral and aortic valvulitis and primary chronic septic endocarditic are presented. Clinical diagnostics of the diseases is described and the key role is assigned to pathognomic (absolute) clinical symptoms. The tendency to progressive fibrosis of endocardial structures with subsequent gradual development of valve dysfunction and stenosis (especially for the mitral valve) is revealed. It is shown that early treatment increases the effective valve area and promotes reversion of mitral stenosis. The possibility of early diagnostics of primary chronic septic endocarditis in combination with adequate etiopathogenetic therapy provide the basis for prevention of acquired valvular disease.
Subject(s)
Aortic Valve Stenosis/etiology , Aortic Valve/pathology , Endocarditis/complications , Mitral Valve Stenosis/etiology , Mitral Valve/pathology , Adult , Aortic Valve Stenosis/pathology , Babesiosis/complications , Bacterial Infections/complications , Chronic Disease , Disease Progression , Endocarditis/diagnosis , Endocarditis/microbiology , Female , Fibrosis , Follow-Up Studies , Herpesviridae Infections/complications , Humans , Male , Mitral Valve Stenosis/pathology , Physical Examination , Prospective Studies , Rubivirus Infections/complications , Rubivirus Infections/epidemiology , Symptom Assessment , Tricuspid Valve Insufficiency/etiology , Tricuspid Valve Insufficiency/pathology , Young AdultSubject(s)
Rubella virus/pathogenicity , Rubivirus Infections/physiopathology , Adult , Enzyme-Linked Immunosorbent Assay , Humans , Immunoglobulin M/blood , Magnetic Resonance Imaging , Male , Rubivirus Infections/blood , Rubivirus Infections/diagnosis , Tomography, X-Ray Computed , Viral Proteins/blood , Viral Proteins/immunologyABSTRACT
El síndrome de la rubéola (SRC) o rubéola congénita se refiere a un grupo de anomalías físicas tales como cataratas, sordera, defectos del corazón, y retraso mental que el bebé manifiesta como resultado de la infección materna y posterior infección fetal con el virus de la rubéola. Lo más probable es que la rubéola materna provoque en la fase de viremia una infección de las vellosidades coriales o de la placenta y produzca una viremia fetal generalizada. El diagnostico se confirma por hallazgos de Ac. Ig M específicos en el suero del recién nacido o mediante cultivos del virus en muestras del lactante. El virus se puede eliminar por la orina durante al menos 1 año. El diagnóstico prenatal se puede establecer mediante aislamiento del virus en el líquido amniótico o por identificación de Ig.M en la sangre del cordón umbilical. Los efectos del virus sobre el feto dependen del momento de la infección; cuanto más joven es el feto, más severa es la enfermedad.
Congenital rubella syndrome (CRS) or congenital rubella refers to a group of physical anomalies such as cataract, deafness, heart conditions, mental retardation that the baby manifests as a result of a maternal infection and posterior fetus infection with rubella virus. Its most probable that maternal rubella provoke an infection of chorionic villi or placenta in the viremic phase producing a generalized fetus viremia. Diagnosis is confirmed with IgM specific antibodies in newborns serum or culture samples of the virus on infants. Virus can be eliminated through urine at least in one year. Prenatal diagnosis can be established when isolating the virus from amniotic fluid or identification of IgM in umbilical cords blood. The effects the virus produce to the fetus depend of the moment of infection; while younger the fetus, the more severe will the disease be.
