1.
J Mol Evol
; 81(5-6): 137-9, 2015 Dec.
Article
in English
| MEDLINE
| ID: mdl-26597944
2.
J Mol Evol
; 81(5-6): 140-3, 2015 Dec.
Article
in English
| MEDLINE
| ID: mdl-26480964
3.
Cold Spring Harb Perspect Biol
; 4(3)2012 Mar 01.
Article
in English
| MEDLINE
| ID: mdl-21441582
ABSTRACT
Aptamers and the SELEX process were discovered over two decades ago. These discoveries have spawned a productive academic and commercial industry. The collective results provide insights into biology, past and present, through an in vitro evolutionary exploration of the nature of nucleic acids and their potential roles in ancient life. Aptamers have helped usher in an RNA renaissance. Here we explore some of the evolution of the aptamer field and the insights it has provided for conceptualizing an RNA world, from its nascence to our current endeavor employing aptamers in human proteomics to discover biomarkers of health and disease.