Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 20 de 126
Filter
1.
Physiol Int ; 107(2): 195-208, 2020 Jun.
Article in English | MEDLINE | ID: mdl-32750027

ABSTRACT

A considerable number of patients arriving in dental offices are being treated with ongoing medication for a variety of chronic diseases. As a result, dentists must be familiar with the potential side effects these therapeutic agents may have on the tissues of the oral cavity, and in particular on the salivary gland. Salivary gland function may be altered by a wide range of medications, leading to effects such as xerostomia, hyposalivation, hypersalivation or even swelling of the glands. These disorders can cause a variety of other health complications. This review will focus on the most common groups of drugs responsible for salivary gland dysfunction, including psychoactive drugs, antidepressants, antipsychotics, antihypertensives, and antihistamines.


Subject(s)
Salivary Gland Diseases/chemically induced , Salivary Glands/drug effects , Dentistry/methods , Humans , Salivary Gland Diseases/pathology , Salivary Gland Diseases/physiopathology , Salivary Glands/pathology , Salivary Glands/physiopathology , Salivation/drug effects
3.
J Craniofac Surg ; 28(2): e127-e129, 2017 Mar.
Article in English | MEDLINE | ID: mdl-28027180

ABSTRACT

Sialadenosis is a rare entity characterized by bilateral diffuse, painless swelling of the parotid glands. Its etiology is not clear; however, it may occur due to adverse effects of some drugs. To our knowledge, sialadenosis due to valproic acid has not been reported in the literature up to date in any child. In this article, the authors presented a child who developed sialadenosis due to valproic acid, and improved after stopping use of the drug.


Subject(s)
Anticonvulsants/adverse effects , Salivary Gland Diseases/chemically induced , Valproic Acid/adverse effects , Child , Humans , Male
4.
Oral Dis ; 22(5): 365-82, 2016 Jul.
Article in English | MEDLINE | ID: mdl-26602059

ABSTRACT

The aim of this paper was to perform a systematic review of the pathogenesis of medication-induced salivary gland dysfunction (MISGD). Review of the identified papers was based on the standards regarding the methodology for systematic reviews set forth by the World Workshop on Oral Medicine IV and the PRISMA statement. Eligible papers were assessed for both the degree and strength of relevance to the pathogenesis of MISGD as well as on the appropriateness of the study design and sample size. A total of 99 papers were retained for the final analysis. MISGD in human studies was generally reported as xerostomia (the sensation of oral dryness) without measurements of salivary secretion rate. Medications may act on the central nervous system (CNS) and/or at the neuroglandular junction on muscarinic, α-and ß-adrenergic receptors and certain peptidergic receptors. The types of medications that were most commonly implicated for inducing salivary gland dysfunction were those acting on the nervous, cardiovascular, genitourinary, musculoskeletal, respiratory, and alimentary systems. Although many medications may affect the salivary flow rate and composition, most of the studies considered only xerostomia. Thus, further human studies are necessary to improve our understanding of the association between MISGD and the underlying pathophysiology.


Subject(s)
Salivary Gland Diseases/chemically induced , Salivary Glands/drug effects , Drug-Related Side Effects and Adverse Reactions , Humans , Oral Medicine/methods , Salivary Gland Diseases/pathology , Salivary Glands/pathology
5.
Clin Oral Investig ; 19(7): 1563-80, 2015 Sep.
Article in English | MEDLINE | ID: mdl-25994331

ABSTRACT

OBJECTIVES: Medication-induced salivary gland dysfunction (MISGD) causes significant morbidity resulting in decreased quality of life. This systematic review assessed the literature on the prevalence, diagnosis, treatment, and prevention of MISGD. MATERIALS AND METHODS: Electronic databases were searched for articles related to MISGD through June 2013. Four independent reviewers extracted information regarding study design, study population, interventions, outcomes, and conclusions for each article. Only papers with acceptable degree of relevance, quality of methodology, and strength of evidence were retained for further analysis. RESULTS: There were limited data on the epidemiology of MISGD. Furthermore, various methods were used to assess salivary flow rate or xerostomia. Preventive and therapeutic strategies included substitution of medications, oral, or systemic therapy with sialogogues, use of saliva substitutes or of electro-stimulating devices. Although there are promising approaches to improve salivary gland function, most studies are characterized by small numbers and heterogeneous methods. CONCLUSIONS: Physicians and dentists should identify the medications associated with xerostomia and salivary gland dysfunction through a thorough medical history. Preferably, health care providers should measure the unstimulated and stimulated whole salivary flow rates of all their patients so that these values can be used as a baseline to rate the complaints of patients who subsequently claim to experience xerostomia or salivary gland dysfunction as well as the possibilities of effectively treating this condition. CLINICAL RELEVANCE: MISGD remains a major burden for the population. This systematic review provides a contemporary in-depth description of the diagnosis and treatment of MISGD.


Subject(s)
Salivary Gland Diseases/chemically induced , Salivary Glands/pathology , Xerostomia/chemically induced , Female , Humans , Male , Prevalence , Risk Factors , Salivary Gland Diseases/diagnosis , Salivary Gland Diseases/therapy , Salivation/drug effects , Xerostomia/diagnosis , Xerostomia/therapy
6.
Article in English | MEDLINE | ID: mdl-25861957

ABSTRACT

OBJECTIVE: This study aimed to systematically review the available literature on the clinical implications of medication-induced salivary gland dysfunction (MISGD). STUDY DESIGN: The systematic review was performed using PubMed, Embase, and Web of Science (through June 2013). Studies were assessed for degree of relevance and strength of evidence, based on whether clinical implications of MISGD were the primary study outcomes, as well as on the appropriateness of study design and sample size. RESULTS: For most purported xerogenic medications, xerostomia was the most frequent adverse effect. In the majority of the 129 reviewed papers, it was not documented whether xerostomia was accompanied by decreased salivary flow. Incidence and prevalence of medication-induced xerostomia varied widely and was often associated with number and dose of medications. Xerostomia was most frequently reported to be mild-to-moderate in severity. Its onset occurred usually in the first weeks of treatment. There was selected evidence that medication-induced xerostomia occurs more frequently in women and older adults and that MISGD may be associated with other clinical implications, such as caries or oral mucosal alterations. CONCLUSIONS: The systematic review showed that MISGD constitutes a significant burden in many patients and may be associated with important negative implications for oral health.


Subject(s)
Salivary Gland Diseases/chemically induced , Salivation/drug effects , Humans , Risk Factors
7.
Med Clin (Barc) ; 144(3): 126-31, 2015 Feb 02.
Article in Spanish | MEDLINE | ID: mdl-24629691

ABSTRACT

Although drugs are the most powerful therapeutic tools we have for improving the quality of life of the population, their use is not free of adverse effects. Today there are many polymedicated patients, and it is difficult to find the cause of their adverse effects that increase exponentially when more than 4 drugs are combined. There are a large number of drugs that can result in numerous adverse effects in the oral cavity. The most common are xerostomia, altered taste, gingival enlargement and mucositis caused by cancer treatment. We also review other disorders of the salivary glands, oral mucosal changes, pigmentations, halitosis, osteonecrosis, opportunistic infections and bleeding diathesis.


Subject(s)
Mouth Diseases/chemically induced , Bisphosphonate-Associated Osteonecrosis of the Jaw/etiology , Disease Susceptibility , Gingival Diseases/chemically induced , Halitosis/chemically induced , Hemorrhagic Disorders/chemically induced , Humans , Immunosuppressive Agents/adverse effects , Mouth Diseases/pathology , Opportunistic Infections/etiology , Pigmentation Disorders/chemically induced , Salivary Gland Diseases/chemically induced , Sialometaplasia, Necrotizing/chemically induced , Stomatitis/chemically induced , Stomatitis/etiology , Taste Disorders/chemically induced , Tongue Diseases/chemically induced , Vasoconstrictor Agents/adverse effects , Xerostomia/chemically induced
8.
Int J Environ Res Public Health ; 11(12): 12429-40, 2014 Nov 28.
Article in English | MEDLINE | ID: mdl-25464135

ABSTRACT

Aluminum absorption leads to deposits in several tissues. In this study, we have investigated, to our knowledge for the first time, aluminum deposition in the salivary glands in addition to the resultant cellular changes in the parotid and submandibular salivary glands in a model of chronic intoxication with aluminum citrate in rats. Aluminum deposits were observed in the parotid and submandibular glands. Immunohistochemical evaluation of cytokeratin-18 revealed a decreased expression in the parotid gland with no changes in the submandibular gland. A decreased expression of α-smooth muscle actin was observed in the myoepithelial cells of both glands. The expression of metallothionein I and II (MT-I/II), a group of metal-binding proteins, which are useful indicators for detecting physiological responses to metal exposure, was higher in both glands. In conclusion, we have shown that at a certain time and quantity of dosage, aluminum citrate promotes aluminum deposition in the parotid and submandibular glands, leads to an increased expression of MT-I/II in both the glands, damages the cytoskeleton of the myoepithelial cells in both glands, and damages the cytoskeleton of the acinar/ductal cells of the parotid glands, with the submandibular glands showing resistance to the toxicity of the latter.


Subject(s)
Citric Acid/toxicity , Salivary Gland Diseases/chemically induced , Salivary Glands/drug effects , Salivary Glands/pathology , Animals , Gene Expression Regulation/drug effects , Immunohistochemistry , Male , Metallothionein/genetics , Metallothionein/metabolism , Rats , Rats, Wistar , Salivary Gland Diseases/metabolism , Salivary Gland Diseases/pathology , Salivary Glands/cytology , Salivary Glands/metabolism
9.
Nihon Jibiinkoka Gakkai Kaiho ; 117(7): 928-31, 2014 Jul.
Article in Japanese | MEDLINE | ID: mdl-25158563

ABSTRACT

Ritodrine hydrochloride (luteonin), a beta-agonist with predominant effects on beta adrenoreceptors such as those of the uterus, is effective in suppressing premature uterine contractions. This medicine was used in drug treatment in the case of threatened premature labor. A 26-year-old female who complained of acute swelling of the bilateral salivary glands was consulted to our otorhinolaryngological department. The soft swelling of the bilateral parotid and submandibular glands had developed after intravenous administration of ritodrine hydrochloride for treatment of her threatened premature labor. In addition, serum amylase levels were elevated. The swelling of the salivary glands and the elevation of the serum amylase subsided following discontinuation of the ritodrine hydrochloride. In salivary glands, too, the beta-adrenoreceptors exist. Following stimulation of those receptors in those glands increased secretion of amylase occurs. Our findings suggested that beta-stimulation by ritodrine hydrochloride led to the swelling of the salivary glands and the elevation of the serum amylase. To our knowledge, in Japan, our case is the first otorhinolaryngological report of swelling of the salivary glands due to ritodrine hydrochloride. Otolaryngologist should therefore have full knowledge regarding swelling of salivary glands due to ritodrine hydrochloride.


Subject(s)
Adrenergic beta-Agonists/adverse effects , Obstetric Labor, Premature/prevention & control , Receptors, Adrenergic, beta/drug effects , Ritodrine/adverse effects , Salivary Gland Diseases/chemically induced , Adult , Female , Humans , Pregnancy , Salivary Gland Diseases/physiopathology , Treatment Outcome
10.
Cancer ; 117(10): 2219-27, 2011 May 15.
Article in English | MEDLINE | ID: mdl-21523736

ABSTRACT

BACKGROUND: The aim of this study was to examine the effect of antineoplastic therapy on dental development and saliva function in recipients of childhood antineoplastic therapy. METHODS: Patients attending the long-term follow-up clinic at Children's Hospital at Westmead, NSW, Australia, were included if they had received treatment prior to 16 years of age and were in remission for more than 5 years. A dental examination and saliva test were performed for each participant. Holtta's Defect Index (HDI) was used to assess tooth aplasia, microdontia, and root-crown ratio on an orthopantomogram (OPG). Multivariable-adjusted regression analyses were used to estimate the association of patient characteristics and treatment modalities with dental outcomes. RESULTS: One hundred six participants (61% male) were recruited (response rate = 88%). The mean HDI score was 24.7 ± 17.8. A cumulative dose of cyclophosphamide >7500 mg/m(2) increased the HDI score by 13.06 (P = .01). Recipients of cyclophosphamide also had significantly increased odds of exhibiting very low saliva flow (<0.7 mL/min) (odds ratio = 12.43; 95% confidence interval, 2.08-74.35; P = .006). CONCLUSIONS: Children and adolescents who received high doses of cyclophosphamide were at increased risk of dental disturbances. Cyclophosphamide recipients were also at greater risk of exhibiting very low saliva flow. This study applied the HDI to patients receiving all forms of antineoplastic treatment and highlights the dose-dependent relation between cumulative dose of cyclophosphamide and dental disturbances.


Subject(s)
Antineoplastic Agents/adverse effects , Cyclophosphamide/adverse effects , Dental Physiological Phenomena/drug effects , Salivary Gland Diseases/chemically induced , Tooth/growth & development , Adolescent , Child , Child, Preschool , Dental Caries/epidemiology , Humans , Male , Tooth/drug effects , Tooth Abnormalities/etiology
11.
J Clin Ultrasound ; 38(8): 438-9, 2010 Oct.
Article in English | MEDLINE | ID: mdl-20872937

ABSTRACT

Swelling of the salivary glands occurring after injection of iodine-based contrast agent is a rare late adverse reaction. Only a few cases in the literature illustrate such ultrasound findings.


Subject(s)
Contrast Media/adverse effects , Iodides/adverse effects , Salivary Gland Diseases/chemically induced , Salivary Gland Diseases/diagnostic imaging , Salivary Glands/diagnostic imaging , Adult , Humans , Ultrasonography
12.
Med. oral patol. oral cir. bucal (Internet) ; 14(3): e108-e113, mar. 2009. graf, tab
Article in English | IBECS | ID: ibc-136119

ABSTRACT

Several studies have shown how cytostatics may cause hypofunction of salivary glands but failed to elucidate any potentially related side effects. Keeping in mind the sialochemical assistance and the role of saliva on the homeostasis of the stomatognathic system, the aim of this study was to establish potential gland disorders in patients submitted to 5- Fluorouracil (5-Fu) and Leucovorin calcium(LV) as well as their correlation with certain oral health disorders that diminish the quality of life. Materials and methods: the focus of this research was observational and longitudinal. Twenty-five patients diagnosed with colon cancer at an initial, intermediate and late phase submitted to specifically devised therapy were assessed. Clinical history, oral health indexes and basal or stimulated saliva samples were recorded. Results: Basal and stimulated flow dropped in the intermediate stage. Stimulated saliva pH decreased during treatment. On basal saliva, urea, sodium and potassium rose during the intermediate phase. Löe and Silness rates as well as simplified bleeding increased during therapy but reverted by the end of the treatment. Depth index of the vestibular gingival sulcus rose during the intermediate phase but did not return. Conclusion: This treatment caused functional salivary gland disorders as evidenced by basal and stimulated hyposialia, and acidification of stimulated saliva pH during the intermediate phase. Increase in basal urea may be due to proteic catabolism arising from plasma or glands. Variation in Na+ and K+ of basal saliva concentrates might be assumed as a possible duct disorder. Recovery of bleeding and Löe and Silness rates may point to a transient inflammatory effect associated to a decrease in salivary flow. Increase in the depth rates of the periodontal vestibular sulcus could be correlated with a higher risk of periodontal disease (AU)


Subject(s)
Humans , Male , Female , Young Adult , Adult , Middle Aged , Aged , Antimetabolites, Antineoplastic/adverse effects , Colonic Neoplasms/drug therapy , Fluorouracil/adverse effects , Leucovorin/adverse effects , Salivary Gland Diseases/chemically induced , Vitamin B Complex/adverse effects , Antimetabolites, Antineoplastic/administration & dosage , Fluorouracil/administration & dosage , Infusions, Intravenous , Leucovorin/administration & dosage , Longitudinal Studies , Vitamin B Complex/administration & dosage
13.
Med Oral Patol Oral Cir Bucal ; 14(3): E108-13, 2009 Mar 01.
Article in English | MEDLINE | ID: mdl-19242388

ABSTRACT

UNLABELLED: Several studies have shown how cytostatics may cause hypofunction of salivary glands but failed to elucidate any potentially related side effects. Keeping in mind the sialochemical assistance and the role of saliva on the homeostasis of the stomatognathic system, the aim of this study was to establish potential gland disorders in patients submitted to 5- Fluorouracil (5-Fu) and Leucovorin calcium (LV) as well as their correlation with certain oral health disorders that diminish the quality of life. MATERIALS AND METHODS: the focus of this research was observational and longitudinal. Twenty-five patients diagnosed with colon cancer at an initial, intermediate and late phase submitted to specifically devised therapy were assessed. Clinical history, oral health indexes and basal or stimulated saliva samples were recorded. RESULTS: Basal and stimulated flow dropped in the intermediate stage. Stimulated saliva pH decreased during treatment. On basal saliva, urea, sodium and potassium rose during the intermediate phase. Löe and Silness rates as well as simplified bleeding increased during therapy but reverted by the end of the treatment. Depth index of the vestibular gingival sulcus rose during the intermediate phase but did not return. CONCLUSION: This treatment caused functional salivary gland disorders as evidenced by basal and stimulated hyposialia, and acidification of stimulated saliva pH during the intermediate phase. Increase in basal urea may be due to proteic catabolism arising from plasma or glands. Variation in Na+ and K+ of basal saliva concentrates might be assumed as a possible duct disorder. Recovery of bleeding and Löe and Silness rates may point to a transient inflammatory effect associated to a decrease in salivary flow. Increase in the depth rates of the periodontal vestibular sulcus could be correlated with a higher risk of periodontal disease.


Subject(s)
Antimetabolites, Antineoplastic/adverse effects , Colonic Neoplasms/drug therapy , Fluorouracil/adverse effects , Leucovorin/adverse effects , Salivary Gland Diseases/chemically induced , Vitamin B Complex/adverse effects , Adult , Aged , Antimetabolites, Antineoplastic/administration & dosage , Female , Fluorouracil/administration & dosage , Humans , Infusions, Intravenous , Leucovorin/administration & dosage , Longitudinal Studies , Male , Middle Aged , Vitamin B Complex/administration & dosage , Young Adult
14.
Auris Nasus Larynx ; 36(3): 310-3, 2009 Jun.
Article in English | MEDLINE | ID: mdl-18635328

ABSTRACT

OBJECTIVE: To evaluate Japanese tolerability to pilocarpine of 5 mg t.i.d. METHODS: From January 2006 to July 2006, 39 patients with xerostomia received 5 mg t.i.d. pilocarpine for at least for 12 weeks unless they had experienced unacceptable adverse effects. All patients received radiotherapy that included the parotid glands in the radiation field >50 Gy. The body weights of the patients ranged from 42 to 73 kg (median 60 kg). RESULTS: Thirty-six of the 39 patients were evaluable. The tolerated rate was only 47%. Of the 25 patients whose body weights were less than 65 kg, the tolerated rate was 36%, whereas the rate of the 11 patients whose body weights were 65 kg or above was 72% (p=0.050). The most common adverse effect was sweating with an incidence of 64%. Response rate, which was defined as the total number of patients with an increase of at least 25 mm from the baseline in the VAS score divided by the number of maintaining patients among those who started pilocarpine after more than 4 months from the start of radiotherapy, was 40% at 12 weeks (n=15). CONCLUSION: For Japanese, 5mg t.i.d. pilocarpine caused a high incidence of unacceptable adverse effects. A lower dose of pilocarpine needs to be considered.


Subject(s)
Muscarinic Agonists/adverse effects , Pilocarpine/adverse effects , Salivary Gland Diseases/chemically induced , Xerostomia/drug therapy , Adult , Aged , Aged, 80 and over , Body Weight , Carcinoma/radiotherapy , Dose-Response Relationship, Drug , Drug Administration Schedule , Female , Head and Neck Neoplasms/radiotherapy , Humans , Male , Middle Aged , Muscarinic Agonists/therapeutic use , Parotid Gland/radiation effects , Pilocarpine/therapeutic use , Radiotherapy/adverse effects , Radiotherapy Dosage , Salivary Gland Diseases/diagnosis , Salivary Gland Diseases/physiopathology , Severity of Illness Index , Xerostomia/etiology
15.
Food Chem Toxicol ; 46(8): 2789-95, 2008 Aug.
Article in English | MEDLINE | ID: mdl-18583012

ABSTRACT

A subchronic oral toxicity study of l-aspartic acid (l-Asp) was conducted with groups of 10 male and 10 female Fischer 344 rats fed a powder diet containing 0%, 0.05%, 1.25%, 2.5% and 5.0% concentrations for 90 days. Serum biochemistry showed treatment-related decreases of blood urea nitrogen, creatinine and uric acid levels in both sexes. In addition, incidences of urinary ketone and protein were significantly increased in treated both sexes, while relative kidney weight was significantly increased in the 5.0% male rat, and regenerative renal tubules with tubular dilation were histopathologically observed in male rats of the 2.5% or greater groups. The observed renal injury was confirmed not to be due to accumulation of alpha2u-globulin. Acinar cell hypertrophy of salivary glands was histopathologically evident in male and female rats of the 2.5% or greater groups. The present results indicate that l-Asp causes toxic effects on kidneys and possibly salivary glands at high dose levels in male and female Fischer 344 rats. Such toxic effects were observed only in animals given 2.5% and/or higher doses of l-Asp. In conclusion, the no-observed-adverse-effect-level (NOAEL) for l-Asp is 1.25% (696.6 mg/kg body weight/day for males and 715.2 mg/kg body weight/day for females) under the present experimental conditions.


Subject(s)
Aspartic Acid/toxicity , Kidney Diseases/chemically induced , Salivary Gland Diseases/chemically induced , Animals , Blood Cell Count , Blood Chemical Analysis , Body Weight/drug effects , Diet , Drinking , Eating , Female , Kidney/pathology , Kidney Diseases/pathology , Male , No-Observed-Adverse-Effect Level , Rats , Rats, Inbred F344 , Salivary Gland Diseases/pathology , Salivary Glands/pathology , Urinalysis
18.
Schweiz Monatsschr Zahnmed ; 117(12): 1210-6, 2007.
Article in German | MEDLINE | ID: mdl-18225398

ABSTRACT

The success of antiretroviral therapy leads to a chronification of HIV-infection resulting in a decline of lethality. The lifelong intake of antiinfectives, though, may result in drug side effects with clinical dental implications. Despite fundamental cellular alterations, including prolonged hemorrhage following surgical interventions, antiretrovirals of all classes, of protease inhibitors, (non-nucleoside) reverse transcriptase inhibitors and of fusion inhibitors may promote oral manifestions like oral ulcera, dysgeusia, salivary gland disorders, papilloma, (peri)oral paresthesia or aphtous stomatitis. Due to inhibitory effects especially of protease inhibitors of cy tochrome P450-isoenzyme CYP3A4 therapeutical interactions with psychotropics/sedatives, antifungal agents, corticoids and intiinfectives, particularly metronidazole, may raise. The application and prescription of systemically metabolized adjuvant drugs as well as the monitoring of the possible progression of HIV infection is a key task in the oral health care of HIV-seropositive patients calling for a close medical coordination of therapeutical interventions.


Subject(s)
Anti-HIV Agents/adverse effects , Dental Care for Chronically Ill , HIV Infections/drug therapy , Oral Ulcer/chemically induced , Salivary Gland Diseases/chemically induced , Cytochrome P-450 Enzyme System/metabolism , Drug Interactions , Dysgeusia/chemically induced , Humans , Immune Reconstitution Inflammatory Syndrome/chemically induced , Lipodystrophy/chemically induced , Papillomavirus Infections/etiology
19.
Gen Dent ; 54(2): 131-8; quiz 139, 2006.
Article in English | MEDLINE | ID: mdl-16689072

ABSTRACT

There is no debate that oral health and general well-being are inextricably bound. Many commonly prescribed medications have associated dental and oral manifestations that often are nonspecific and can vary in significance. This article reviews many common oral manifestations of systemic drugs, including the clinical manifestations, diagnosis, and treatment of these conditions.


Subject(s)
Drug-Related Side Effects and Adverse Reactions , Mouth Diseases/chemically induced , Gingival Overgrowth/chemically induced , Humans , Lichenoid Eruptions/chemically induced , Pemphigus/chemically induced , Salivary Gland Diseases/chemically induced , Taste Disorders/chemically induced
20.
Minerva Stomatol ; 55(5): 249-70, 2006 May.
Article in English, Italian | MEDLINE | ID: mdl-16688102

ABSTRACT

A wide range of non neoplastic disorders can affect the salivary glands, although the more common are: mumps, acute suppurative sialadenitis, Sjögren's syndrome and drug-induced xerostomia. Salivary dysfunction is not a normal consequence of old age, and can be due to systemic diseases, medications or head and neck radiotherapy. Diagnosis of salivary disorders begins with a careful medical history, followed by a cautious examination. While complaints of xerostomia may be indicative of a salivary gland disorder, salivary diseases can present without symptoms. Therefore, routine examination of salivary function must be part of any head, neck, and oral examination. Health-care professionals can play a vital role in identifying patients at risk for developing salivary dysfunction, and should provide appropriate preventive and interventive techniques that will help to preserving a person's health, function, and quality of life. The present work provides an overview of most of the non neoplastic disorders of the salivary glands, in which the general presentation, pathology, and treatments are discussed.


Subject(s)
Salivary Gland Diseases , Adolescent , Adult , Child , HIV Infections/complications , Humans , Mucocele/diagnosis , Mucocele/pathology , Mumps/diagnosis , Mumps/epidemiology , Mumps/prevention & control , Parasympatholytics/adverse effects , Salivary Gland Calculi/diagnosis , Salivary Gland Calculi/epidemiology , Salivary Gland Calculi/metabolism , Salivary Gland Calculi/therapy , Salivary Gland Diseases/chemically induced , Salivary Gland Diseases/congenital , Salivary Gland Diseases/diagnosis , Salivary Gland Diseases/pathology , Salivary Gland Diseases/therapy , Salivary Glands/abnormalities , Sialadenitis/epidemiology , Sialadenitis/etiology , Sialadenitis/microbiology , Sialadenitis/virology , Sialometaplasia, Necrotizing/diagnosis , Sialometaplasia, Necrotizing/etiology , Sialometaplasia, Necrotizing/pathology , Xerostomia/chemically induced , Xerostomia/pathology
SELECTION OF CITATIONS
SEARCH DETAIL
...