1.
Psychiatr Neurol Med Psychol (Leipz)
; 28(3): 163-73, 1976 Mar.
Article
in German
| MEDLINE
| ID: mdl-967948
ABSTRACT
According to the hypothesis of Osmond, Harley-Mason and Smythies on abnormal methylation products in the catecholamine metabolism in schizophrenics, the excretion of 3,4-dimethoxyphenylethylamine (3,4-DMPEA) in the urine was examined in 80 patients with endogenous psychoses and in 20 normal persons. In 38% of the patients 3,4-DMPEA was found, whereas no 3,4-DMPEA was found in normal persons. When the biochemical findings obtained are correlated to the corresponding diagnoses the highest incidence of positive findings was observed in paranoid-hallucinatory schizophrenics with 71% in males and 75% in females. The signification of controls during the course of the experiments is emphasized.
Subject(s)
Dimethoxyphenylethylamine/urine , Phenethylamines/urine , Schizophrenia/urine , Adolescent , Adult , Aged , Bipolar Disorder/urine , Chemical Phenomena , Chemistry , Dimethoxyphenylethylamine/metabolism , Female , Humans , Male , Middle Aged , Models, Chemical , Schizophrenia/metabolism , Schizophrenia, Catatonic/urine , Schizophrenia, Disorganized/urine , Schizophrenia, Paranoid/urine , Schizotypal Personality Disorder/urine , Sex Factors
2.
Arzneimittelforschung
; 23(6): 884-6, 1973 Jun.
Article
in English
| MEDLINE
| ID: mdl-4740778