ABSTRACT
Liposomes containing natural flavonoid dihydroquercetin, phospholipid lecithin, and zwitterionic amino acid glycine were used for the therapy of glacial acetic acid-induced chemical burn. No inflammatory reaction was observed in the region of wound. The area of postburn injury did not increase in time. Planimetry and histological studies showed that improved skin regeneration was accompanied by repair of hair follicles and sebaceous glands.
Subject(s)
Burns, Chemical/drug therapy , Regeneration/drug effects , Skin/drug effects , Skin/injuries , Acetic Acid , Animals , Antioxidants/therapeutic use , Burns, Chemical/immunology , Glycine/therapeutic use , Hair Follicle/drug effects , Hair Follicle/injuries , Hair Follicle/pathology , Lecithins/therapeutic use , Liposomes/therapeutic use , Male , Quercetin/analogs & derivatives , Quercetin/therapeutic use , Rats , Rats, Wistar , Sebaceous Glands/drug effects , Sebaceous Glands/injuries , Sebaceous Glands/pathology , Skin/pathology , Time Factors , Wound Healing/drug effectsABSTRACT
BACKGROUND: During laser-assisted hair removal, sebaceous glands closely associated with hair follicles might also be affected. OBJECTIVE: We investigated the effect of the long-pulsed ruby laser on sebaceous glands. METHODS: Sebum excretion rates (SERs) of 16 subjects were measured quantitatively by means of sebum-absorbent tape and analyzed by means of image analysis techniques on laser-treated sites, compared with adjacent untreated areas. Evaluation was done at an average of 9 months (range, 4.5 to 12 months) after the last treatment. Histologic examinations were performed on 3 representative subjects before treatment, immediately after treatment, and 9 months after the last treatment. RESULTS: Significant increases in SERs were observed in 11 of 16 subjects (68.75%). Three subjects (18.75%) showed lower SERs, whereas 2 subjects (12.5%) demonstrated no difference in SERs between treated and untreated areas. Biopsy specimens showed an apparent reduction in sebaceous gland size. Specimens taken immediately after laser irradiation revealed sporadic damage to sebaceous glands. CONCLUSION: In some patients a variable but statistically significant increase in sebum excretion occurs 4 to 12 months after ruby-laser hair removal treatment at high fluences. A reduction in sebaceous gland sizes on laser-treated areas was observed. We hypothesize that decreased resistance to sebum outflow may explain this result, following miniaturization or absence of hair shaft after ruby laser treatment. Further study is needed to assess mechanisms for this interesting response.
Subject(s)
Hair Removal/adverse effects , Laser Therapy/adverse effects , Sebaceous Glands/injuries , Sebum/metabolism , Adult , Biopsy , Female , Hair Removal/methods , Humans , Male , Pilot Projects , Sebaceous Glands/pathology , Time FactorsABSTRACT
Com base em importantes trabalhos da literatura internacional realizados na última década sobre Pitiríase versicolor, os autores fazem uma extensa revisäo bibliográfica do tema, abordando especialmente aspectos históricos, etiológicos, etiopatogênicos, epidemiológicos, histopatológicos, clínicos, diagnósticos e terapêuticos
