ABSTRACT
Dupilumab is a monoclonal antibody that inhibits interleukin-4 and interleukin-13 signaling. It is the first biologic agent to demonstrate efficacy in treating moderate-to-severe refractory atopic dermatitis [1, 2]. Although dupilumab provides promise for the treatment of atopic and allergic conditions, clinicians should take into account its novelty and the potential for unexpected adverse events. We present a patient who developed Sézary syndrome following the initiation of dupilumab.
Subject(s)
Antibodies, Monoclonal, Humanized/adverse effects , Interleukin-4 Receptor alpha Subunit/antagonists & inhibitors , Sezary Syndrome/chemically induced , Skin Neoplasms/chemically induced , Antibodies, Monoclonal, Humanized/therapeutic use , Dermatitis, Atopic/drug therapy , Humans , Male , Middle AgedABSTRACT
Infliximab, a tumour necrosis factor (TNF)-alpha antagonist, has shown striking efficacy in the treatment of chronic inflammatory rheumatological diseases such as rheumatoid arthritis and ankylosing spondylitis. However, long-term follow-up studies support that treatment with infliximab is associated with an increased risk of non-Hodgkin lymphoma. So far, few cases of cutaneous lymphoma have been reported in patients receiving TNF-alpha-blocking agents. We report a patient who developed Sézary syndrome 17 months after the onset of infliximab therapy for ankylosing spondylitis. Cutaneous lesions partially remitted following infliximab withdrawal and methotrexate treatment. Although the causal link between infliximab and the emergence of Sézary syndrome is uncertain, the present case raises the need for exhaustive long-term registries of malignancies, including primary cutaneous lymphomas, in patients receiving TNF-alpha-blocking agents.
Subject(s)
Antibodies, Monoclonal/adverse effects , Antirheumatic Agents/adverse effects , Lymphoma, Non-Hodgkin/chemically induced , Sezary Syndrome/chemically induced , Skin Neoplasms/chemically induced , Spondylitis, Ankylosing/drug therapy , Aged , Antimetabolites, Antineoplastic/therapeutic use , Humans , Infliximab , Male , Methotrexate/therapeutic use , Risk Factors , Treatment Outcome , Tumor Necrosis Factor-alpha/drug effectsSubject(s)
Anti-Bacterial Agents/adverse effects , Bone Marrow/drug effects , Liver/drug effects , Minocycline/adverse effects , Adult , Female , Fever/chemically induced , Humans , Liver/enzymology , Liver/pathology , Lymphatic Diseases/chemically induced , Parotitis/chemically induced , Sezary Syndrome/chemically induced , Sezary Syndrome/pathologyABSTRACT
BACKGROUND: The phenytoin-induced hypersensitivity syndrome is characterized by the development of fever, rash, lymphadenopathy, and hepatitis associated with leukocytosis and eosinophilia. This article describes the unusual occurrence of a pseudo-Sézary syndrome in the days following the introduction of phenytoin treatment. OBSERVATION: A phenytoin-induced erythroderma developed in a 60-year-old woman the histologic, cytologic, and immunologic characteristics of an erythrodermal cutaneous T-cell lymphoma of the Sézary syndrome type with lymph node involvement. The dramatic improvement after withdrawal of drug therapy and the absence of recurrence 5 years after led us to consider it as a hydantoin-induced pseudolymphoma. CONCLUSIONS: Although lymph node pseudolymphomas induced by phenytoin are well known, few cases of hydantoin-induced mycosis fungoides have been reported in the literature. We present herein the first case of a Sézary-like syndrome associated with phenytoin therapy. Such a patient must be monitored regularly because of the risk of a true malignant lymphoma developing even many years later.
