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Pathol Biol (Paris) ; 44(4): 249-53, 1996 Apr.
Article in French | MEDLINE | ID: mdl-8763586

ABSTRACT

Neisseria gonorrhoeae (Strain A) induces a sialyl-transferase when treated with a very low concentration of cytidine 5'monophospho-N-acetyl neuraminic acid, 2 x 10(-3) nmol.ml-1, a concentration which is insufficient to produce an adequate resistance to human serum complement. The sialyl-transferase activity was detected by measurement of fixed 14C radio-labeled sialyl groups. Without this stimulation, there was practically no transfer of sialyl groups. The gonococcal sialyl-transferase could be considered inducible.


Subject(s)
Cytidine Monophosphate N-Acetylneuraminic Acid/pharmacology , Neisseria gonorrhoeae/drug effects , Sialyltransferases/pharmacokinetics , Anti-Bacterial Agents/pharmacology , Carbon Radioisotopes , Chloramphenicol/pharmacology , In Vitro Techniques , Neisseria gonorrhoeae/metabolism , Radiometry , Stimulation, Chemical
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