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J Pediatr ; 86(6): 892-8, 1975 Jun.
Article in English | MEDLINE | ID: mdl-236368

ABSTRACT

In 1967, Kawasaki, in Japan, first described a new syndrome affecting infants and young children-an acute, febrile illness with mucocutaneous involvement associated with swelling of cervical lymph nodes. The prognosis is usually good but recently it has become evident that 1-2 percent of the patients die suddenly from acute heart failure. Infantile polyarteritis (nodosa-like arteritis) accompained by coronary aneurysm and thrombosis has been noted in postmortem examinations. Twenty patients surviving the illness were examined by coronary angiography; 12 of the 20 had abnormal coronary angiograms; seven patients had coronary aneurysms. Complete regression of the coronary aneurysms was proved in two patients at subsequent angiography. One patient developed mitral regurgitation as a result of papillary muscle dysfunction. One had a coronary aneurysm without symptoms two years after the onset of illness.


Subject(s)
Aneurysm/etiology , Coronary Disease/etiology , Lymphatic Diseases/complications , Polyarteritis Nodosa/etiology , Acute Disease , Aneurysm/diagnosis , Angiocardiography , Child , Child, Preschool , Coronary Disease/diagnosis , Coronary Disease/prevention & control , Electrocardiography , Female , Fever , Humans , Infant , Lymph Nodes/physiopathology , Lymphatic Diseases/mortality , Male , Mucous Membrane/physiopathology , Phonocardiography , Skin Manifestations/physiopathology
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