ABSTRACT
Background: High sensitivity C-reactive protein (hs-CRP) is commonly used in clinical practice to assess cardiovascular risk. However, a correlation has not yet been established between the absolute levels of peripheral and central hs-CRP. Objective: To assess the correlation between serum hs-CRP levels (mg/L) in a peripheral vein in the left forearm (LFPV) with those in the coronary sinus (CS) of patients with coronary artery disease (CAD) and a diagnosis of stable angina (SA) or unstable angina (UA). Methods: This observational, descriptive, and cross-sectional study was conducted at the Instituto do Coração, Hospital das Clinicas, Faculdade de Medicina, Universidade de São Paulo, and at the Hospital Beneficência Portuguesa de Sao Paulo, where CAD patients referred to the hospital for coronary angiography were evaluated. Results: Forty patients with CAD (20 with SA and 20 with UA) were included in the study. Blood samples from LFPV and CS were collected before coronary angiography. Furthermore, analysis of the correlation between serum levels of hs-CRP in LFPV versus CS showed a strong linear correlation for both SA (r = 0.993, p < 0.001) and UA (r = 0.976, p < 0.001) and for the entire sample (r = 0.985, p < 0.001). Conclusion: Our data suggest a strong linear correlation between hs-CRP levels in LFPV versus CS in patients with SA and UA. .
Fundamento: A proteína C-reativa de alta sensibilidade (PCR-as) é comumente utilizada na prática clínica para avaliar o risco cardiovascular. Entretanto, a correlação entre os níveis séricos de PCR-as (valores absolutos) periférico versus central ainda não foi feita. Objetivo: Avaliar a correlação entre os níveis séricos de PCR-as (mg/L) em veia periférica do antebraço esquerdo (VPAE) versus seio coronário (SC), em pacientes portadores de doença arterial coronária (DAC) com diagnóstico de angina estável (AE) ou angina instável (AI). Métodos: Estudo observacional, descritivo, transversal, realizado no Instituto do Coração do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo e no Hospital Beneficência Portuguesa de São Paulo, onde foram avaliados os pacientes encaminhados ao hospital com DAC para angiografia coronária. Resultados: Quarenta pacientes com DAC (20 AE e 20 AI) foram incluídos no estudo. Amostras de sangue na VPAE e SC foram coletadas simultaneamente antes da angiografia coronária. A análise de correlação entre os níveis séricos de PCR-as em VPAE versus SC mostrou forte correlação linear tanto para AE (r = 0,993, p < 0,001) como para AI (r = 0,976, p < 0,001) e em toda a amostra (r = 0,985, p < 0,001). Conclusão: Nossos dados sugeriram forte correlação linear entre os níveis de PCR-as em VPAE versus SC na AE e AI. .
Subject(s)
Female , Humans , Infant, Newborn , Male , Pregnancy , Young Adult , Imaging, Three-Dimensional , Magnetic Resonance Imaging , Mouth Neoplasms/diagnosis , Mouth Neoplasms/embryology , Pregnancy Trimester, Third , Skull Base Neoplasms/diagnosis , Skull Base Neoplasms/embryology , Teratoma/diagnosis , Teratoma/embryology , Ultrasonography, Prenatal , Mouth Neoplasms/pathology , Mouth Neoplasms/therapy , Obstetric Labor, Premature/therapy , Perinatal Death , Skull Base Neoplasms/pathology , Skull Base Neoplasms/therapyABSTRACT
A 20-year-old nulliparous woman was referred due a cervical mass in the fetus in an ultrasound examination performed in the 25th week of pregnancy. The exam revealed an irregular, solid-cystic heterogeneous mass measuring 75x54 mm that came to the exterior through the mouth of the fetus. Three-dimensional ultrasound and magnetic resonance imaging confirmed the diagnosis of epignathus teratoma and the normal finding of the central nervous system. The patient was admitted at 28 weeks, in premature labor. Tocolysis, corticosteroid and amniotic fluid drainage were programmed to be performed before conducting ex utero intrapartum treatment (EXIT). However, there was premature rupture of membranes and the EXIT procedure was brought forward. After premature placental abruption, the newborn's birth was concluded. Tracheostomy was performed, but the newborn's condition progressed to bradycardia and death in a few minutes.
Subject(s)
Imaging, Three-Dimensional , Magnetic Resonance Imaging , Mouth Neoplasms/diagnosis , Mouth Neoplasms/embryology , Pregnancy Trimester, Third , Skull Base Neoplasms/diagnosis , Skull Base Neoplasms/embryology , Teratoma/diagnosis , Teratoma/embryology , Ultrasonography, Prenatal , Female , Humans , Infant, Newborn , Male , Mouth Neoplasms/pathology , Mouth Neoplasms/therapy , Obstetric Labor, Premature/therapy , Perinatal Death , Pregnancy , Skull Base Neoplasms/pathology , Skull Base Neoplasms/therapy , Young AdultABSTRACT
Chordoma is a rare malignant tumor of the bone; it arises from embryonic remnants of the primitive notochord and occurs along the midline from the skull base to the sacrum. In this article, we reviewed the origin, location, clinical, histopatological and imaging features, treatment, and differential diagnosis of chordoma.
Subject(s)
Chordoma/diagnosis , Neuroimaging/methods , Skull Base Neoplasms/diagnosis , Spinal Neoplasms/diagnosis , Biomarkers, Tumor , Chondrosarcoma/diagnosis , Chordoma/complications , Chordoma/diagnostic imaging , Chordoma/embryology , Chordoma/pathology , Chordoma/therapy , Combined Modality Therapy , Contrast Media , Cranial Irradiation , Craniotomy , Diagnosis, Differential , Giant Cell Tumors/diagnosis , Humans , Magnetic Resonance Imaging/methods , Neoplasm Invasiveness , Notochord/pathology , Osteolysis/etiology , Osteolysis/pathology , Plasmacytoma/diagnosis , Skull Base Neoplasms/complications , Skull Base Neoplasms/diagnostic imaging , Skull Base Neoplasms/embryology , Skull Base Neoplasms/pathology , Skull Base Neoplasms/therapy , Spinal Cord Compression/etiology , Spinal Cord Compression/pathology , Spinal Neoplasms/complications , Spinal Neoplasms/diagnostic imaging , Spinal Neoplasms/embryology , Spinal Neoplasms/pathology , Spinal Neoplasms/therapy , Tomography, X-Ray Computed/methodsABSTRACT
The sphenoid bone represents a complex structure in terms of anatomy and embryology. Indeed, it is formed by the fusion of different primordia whose embryonic origins are different. In mammals, it is possible to distinguish two components of this bone: the orbitosphenoid and the basi-post-sphenoid derive from the cephalic mesoderm whereas the alisphenoid and the basi-pre-sphenoid are from neural crest cell origin. The genetic control of the development of these two components is different further increasing the heterogeneity of these components. The sphenoid bone has been linked with several developmental diseases: chordomas, tumors arising from notochordal remnants; persistence of the craniopharyngeal canal may result in the occurrence of trans-sphenoidal encephaloceles.