ABSTRACT
Reactions to combined attenuvax-smallpox vaccine were studied, and were compared with those produced by each type of vaccine separately, in children from one to five years of age, controlled by maternal-child care centers under the National Health Service in Santiago, Chile. Combined freeze-dried and preblended attenuvax-smallpox vaccine and freeze-dried "Dryvax" smallpox vaccine were used. The combined vaccine was jet-injected, while the measles vaccine was administered in the form of subcutaneous injections, and the smallpox vaccine by the multipuncture technique
The new preblended and combined attenuvax-smallpox vaccine administered by jet injection produces general clinical reactions similar to or milder than those caused by each vaccine when administered separately
"Takes" were recorded in 96.9 per cent of children inoculated with the combined vaccine, which is an excellent result
To judge from the rise in titers in serological tests counts for both viruses in the cases inoculated, there was no evidence of interference between antigens. The conversion rate for each virus closely resembled that obtained when each vaccine was administered separately, and the geometric mean of the hemoagglutination inhibition titers was also very similar for the combined vaccine and for each vaccine administered separately
Revaccination against smallpox in children inoculated two months earlier with the ... (AU)
Subject(s)
Measles Vaccine/therapy , Measles Vaccine/adverse effects , Smallpox Vaccine/therapy , Smallpox Vaccine/adverse effects , Communicable Diseases/immunology , Antigen-Antibody Reactions , ChileABSTRACT
The author presents the results of smallpox vaccination of 220 children under six months of age and the follow-up of 200 vaccines, 47 of them only one month old
Lyophilized vaccine produced by Instituto Oswaldo Cruz of the Ministry of Health and Instituto de Pesquisas Biológicas of the Secretary of Health of the State of Rio Grando do Sul, was used. THe vaccination was perfomred with bifurcated needles and an average of 10 days after vaccination. No side effects were observed and fever above 38 degrees Centigrade was present only in those cases where smallpox vaccine had been combined with DPT and Sabin vaccine
Among the conclusions, the author points out advantages and good results from early smallpox vaccination with no contraindications; the antibody formation capability of young children, notwithstanding the possibility that manternal antibodies might have been transmitted to them; the overall acceptance of the procedure by physicians and auxiliary personnel and by the families involved(AU)
