ABSTRACT
The study is based upon the results of clinical laboratory examination of 33 patients with diagnosis of recurrent herpetic stomatitis. The control group included 26 healthy persons. In patients with manifestations of herpetic infection of mucous tunic of oral cavity the pronounced abnormalities of indicators of secretory immunity (lactoferrin, secretory immunoglobulin A) correlating with hygiene index are established. At the same time, indicator of antiviral immunity (alpha-interferon) characterized by absence of significant changes in this group of patients.
Subject(s)
Mouth Mucosa/immunology , Stomatitis, Herpetic/immunology , Adolescent , Adult , Case-Control Studies , Female , Humans , Immunoglobulin A/analysis , Interferon-alpha/analysis , Lactoferrin/analysis , Male , Mouth Mucosa/chemistry , Mouth Mucosa/metabolism , Stomatitis, Herpetic/metabolismABSTRACT
Oral mucosal inflammation evolves in response to microbial pathogens and non-infectious antigens which activate humoral and cell-mediated immunologic processes. Most of these disease processes invoke a leukocyte response culminating in cellular infiltration of the submucosa and, to some degree, transmigration into the epithelium itself. Calprotectin, a leukocyte-derived dimeric protein complex that has potent antibacterial and antifungal effects, has recently been identified in skin and mucosal keratinocytes implying that epithelium may biochemically contribute to the overall mechanism of host defense. In this study, the upregulation of calprotectin as assessed immunohistochemically is pursued for oral diseases of immunopathologic, fungal and viral origin. In lichen planus, candidiasis, herpes virus stomatitis, and oral hairy leukoplakia, calprotectin was found to be expressed to a significantly higher level than in normal control mucosal samples.
Subject(s)
Calcium-Binding Proteins/analysis , Cell Adhesion Molecules, Neuronal/analysis , Keratinocytes/metabolism , Mouth Mucosa/metabolism , Mouth Mucosa/pathology , Stomatitis/metabolism , Stomatitis/pathology , Antigens, Surface/analysis , Antigens, Surface/genetics , Calcium-Binding Proteins/genetics , Candidiasis, Oral/metabolism , Candidiasis, Oral/pathology , Cell Adhesion Molecules, Neuronal/genetics , Cell Nucleus/metabolism , Cell Nucleus/ultrastructure , Cytoplasm/metabolism , Cytoplasm/ultrastructure , Epithelium/metabolism , Epithelium/pathology , Gene Expression , Humans , Leukocyte L1 Antigen Complex , Leukoplakia, Hairy/metabolism , Leukoplakia, Hairy/pathology , Lichen Planus, Oral/metabolism , Lichen Planus, Oral/pathology , Lip/metabolism , Lip/pathology , Mouth Floor , Palate , Stomatitis, Herpetic/metabolism , Stomatitis, Herpetic/pathology , Tongue/metabolism , Tongue/pathologyABSTRACT
In healthy white rats [125I]-desoxyuridine, [3H]-thymidine, 2-[14C]-uracyl, 8-[14C]-adenine and [3H)-uridine were used to demonstrate that the [125I]-desoxyuridine metabolism in oral mucosa is analogous to that of thymidine and different from metabolic pathways of another nucleoside uridine and nitrogen purine and pyrimidine bases of adenine and uracyl. In rats infected with herpes simplex virus, the relative tissue/blood 123I radioactivity increased after a [125I]-desoxyuridine injection. The authors suggest that the mechanism of [125I]-desoxyuridine action relies on its involvement into the viral host cell DNA.
Subject(s)
Idoxuridine/pharmacokinetics , Mouth/metabolism , Stomatitis, Herpetic/metabolism , Adenine/pharmacokinetics , Animals , Carbon Radioisotopes , Iodine Radioisotopes , Rats , Thymidine/pharmacokinetics , Time Factors , Tritium , Uracil/pharmacokinetics , Uridine/pharmacokineticsABSTRACT
Transient alteration of theophylline half-life resulting in theophylline neurotoxicity is reported in a nine-year-old child. The alteration in theophylline elimination half-life was associated with Herpes simplex gingivostomatitis. This association has not previously been demonstrated. The report is contrasted with a study of theophylline clearance variability in children.
