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1.
J Clin Epidemiol ; 170: 111334, 2024 Jun.
Article in English | MEDLINE | ID: mdl-38548231

ABSTRACT

OBJECTIVE: Successful implementation of stroke rehabilitation guidelines demands high-quality practice standards tailored to targeted sociodemographic contexts. The primary objective is to determine the quality differences in post-stroke rehabilitation practice guidelines (PGs), when comparing high-income countries (HIC) and low or middle-income countries (LMIC). STUDY DESIGN AND SETTING: We conducted a scoping review of PGs in English or Spanish, published between 2012 and 2021, and providing recommendations on post-stroke rehabilitation. We used Search engines, databases, guideline libraries, gray literature, and references from previous reviews on post-stroke rehabilitation as sources of evidence. Quality assessment of PGs was performed using 6P's, ELSE, IOM, and AGREE II instruments. We evaluated each item using a scale between 0 to 3, based on the confidence of adherence to the standard. For AGREE II, we followed the instruction manual for scoring. At least two reviewers were independently involved in every step of the process. A cloud-based spreadsheet was used to chart data. We compared the results of PGs originating from HIC with those from LMIC. RESULTS: The inclusion criteria were met by 35 documents, which were subjected to evaluation. The study included 21 documents from HIC and 14 from middle-income countries (MIC). No manuscripts from low-income countries were available for inclusion in the study. The quality of PGs from MIC was found to be lower, in terms of methodological rigor and adherence to international recommendations for guidelines development. PGs from both groups of countries failed to include all target audiences and stakeholders (according to the 6P's criteria) and integration of ethical, legal, social, and economic considerations. CONCLUSION: There are gaps in the quality and availability of stroke rehabilitation guidelines worldwide, especially in LMIC. Designing and providing financial support for the implementation of high-quality guidelines will contribute to more effective implementation strategies in stroke rehabilitation programs and lead to improved patient outcomes.


Subject(s)
Developed Countries , Developing Countries , Stroke Rehabilitation , Humans , Stroke Rehabilitation/statistics & numerical data , Stroke Rehabilitation/standards , Stroke Rehabilitation/methods , Practice Guidelines as Topic/standards , Global Health , Income/statistics & numerical data , Stroke
2.
Melbourne; Stroke Foundation; July 27, 2023. 30 p. tab.
Non-conventional in English | BIGG - GRADE guidelines | ID: biblio-1532765

ABSTRACT

The Stroke Foundation is a national charity that partners with the community to prevent, treat and beat stroke. We stand alongside stroke survivors and their families, healthcare professionals and researchers. We build community awareness and foster new thinking and innovative treatments. We support survivors on their journey to live the best possible life after stroke. We are the voice of stroke in Australia and we work to: • Raise awareness of the risk factors, signs of stroke and promote healthy lifestyles. • Improve treatment for stroke to save lives and reduce disability. • Improve life after stroke for survivors. • Encourage and facilitate stroke research. • Advocate for initiatives to prevent, treat and beat stroke. • Raise funds from the community, corporate sector and government to continue our mission. The Stroke Foundation has been developing stroke guidelines since 2002 and in 2017 released the fourth edition. In order for the Australian Government to ensure up-to-date, best-practice clinical advice is provided and maintained to healthcare professionals, the NHMRC requires clinical guidelines be kept current and relevant by reviewing and updating them at least every five years. As a result, the Stroke Foundation, in partnership with Cochrane Australia, have moved to a model of living guidelines, in which recommendations are continually reviewed and updated in response to new evidence. This approach was piloted in a three year project (July 2018 - June 2021) funded by the Australian Government via the Medical Research Future Fund. This online version of the Clinical Guidelines for Stroke Management updates and supersedes the Clinical Guidelines for Stroke Management 2017. The Clinical Guidelines have been updated in accordance with the 2011 NHMRC Standard for clinical practice guidelines and therefore recommendations are based on the best evidence available. The Clinical Guidelines cover the whole continuum of stroke care, across 8 chapters. Review of the Clinical Guidelines used an internationally recognised guideline development approach, known as GRADE (Grading of Recommendations Assessment, Development and Evaluation), and an innovative guideline development and publishing platform, known as MAGICapp (Making Grade the Irresistible Choice). GRADE ensures a systematic process is used to develop recommendations that are based on the balance of benefits and harms, patient values, and resource considerations. MAGICapp enables transparent display of this process and access to additional practical information useful for guideline recommendation implementation.


Subject(s)
Humans , Stroke/prevention & control , Prehospital Care , Stroke Rehabilitation/standards
3.
PLoS One ; 17(2): e0263397, 2022.
Article in English | MEDLINE | ID: mdl-35113968

ABSTRACT

BACKGROUND: Impairments to comprehension and production of speech (aphasia, dysarthria) and swallowing disorders (dysphagia) are common sequelae of stroke, reducing patients' quality of life and social participation. Treatment oriented on evidence-based guidelines seems likely to improve outcomes. Currently, little is known about guideline adherence in stroke aftercare for the above-mentioned sequelae. This study aims to analyse guideline adherence in the treatment of aphasia, dysarthria and dysphagia after stroke, based on suitable test parameters, and to determine factors that influence the implementation of recommended therapies. METHODS: Six test parameters were defined, based on systematic study of guidelines for the treatment of speech impairments and swallowing disorders (e.g. comprehensive diagnostics, early initiation and continuity). Guideline adherence in treatment was tested using claims data from four statutory health insurance companies. Multivariate logistic and linear regression analyses were performed in order to test the outcomes. RESULTS: 4,486 stroke patients who were diagnosed with specific disorders or received speech therapy were included in the study. The median age was 78 years; the proportion of women was 55.9%. Within the first year after the stroke, 90.3% of patients were diagnosed with speech impairments and swallowing disorders. Overall, 44.1% of patients received outpatient speech and language therapy aftercare. Women were less frequently diagnosed with specific disorders (OR 0.70 [95%CI:0.55/0.88], p = 0.003) and less frequently received longer therapy sessions (OR 0.64 [95%CI:0.43/0.94], p = 0.022). Older age and longer hospitalization duration increased the likelihood of guideline recommendations being implemented and of earlier initiation of stroke aftercare measures. CONCLUSIONS: Our observations indicate deficits in the implementation of guideline recommendations in stroke aftercare. At the same time, they underscore the need for regular monitoring of implementation measures in stroke aftercare to address group-based disparities in care.


Subject(s)
Guideline Adherence , Insurance Claim Review , Language Therapy/standards , Speech Therapy/standards , Stroke Rehabilitation/standards , Stroke/complications , Aftercare , Aged , Aphasia/rehabilitation , Data Analysis , Deglutition Disorders/rehabilitation , Dysarthria/rehabilitation , Female , Germany , Humans , Insurance, Health/standards , Male , Middle Aged , Multivariate Analysis , Quality of Life , Registries , Speech , Treatment Outcome
4.
Phys Ther ; 101(12)2021 12 01.
Article in English | MEDLINE | ID: mdl-34636908

ABSTRACT

OBJECTIVE: The iWalk study showed significant increase in use of the 10-Meter Walk Test (10MWT) and 6-Minute Walk Test (6MWT) poststroke following provision of a toolkit. This paper examined the influence of contextual circumstances on use of the toolkit and implementation strategy across acute care and inpatient and outpatient rehabilitation settings. METHODS: A theory-based toolkit and implementation strategy was designed to support guideline recommendations to use standardized tools for evaluation of walking, education, and goal-setting poststroke. The toolkit comprised a mobile app, video, and educational guide outlining instructions for 3 learning sessions. After completing learning sessions, 33 physical therapists and 7 professional leaders participated in focus groups or interviews. As part of a realist evaluation, the study compared and synthesized site-specific context-mechanism-outcome descriptions across sites to refine an initial theory of how the toolkit would influence practice. RESULTS: Analysis revealed 3 context-mechanism-outcomes: (1) No onsite facilitator? No practice change in acute care: Without an onsite facilitator, participants lacked authority to facilitate and coordinate the implementation strategy; (2) Onsite facilitation fostered integration of select practices in acute care: When onsite facilitation occurred in acute care, walk test administration and use of reference values for patient education were adopted variably with high functioning patients; (3) Onsite facilitation fostered integration of most practices in rehabilitation settings: When onsite facilitation occurred, many participants incorporated 1 or both tests to evaluate and monitor walking capacity, and reference values were applied for inpatient and outpatient education and goal setting. Participants preferentially implemented the 10MWT over the 6MWT because set-up and administration were easier and a greater proportion of patients could walk 10 m. CONCLUSION: Findings underscore contextual factors and activities essential to eliciting change in assessment practice in stroke rehabilitation across care settings. IMPACT: This study shows that to foster recommended walking assessment practices, an onsite facilitator should be present to enable learning sessions and toolkit use.


Subject(s)
Stroke Rehabilitation/methods , Stroke Rehabilitation/standards , Walk Test/methods , Walk Test/standards , Adult , Female , Humans , Male , Middle Aged , Translational Science, Biomedical , Young Adult
5.
Medicine (Baltimore) ; 100(37): e27256, 2021 Sep 17.
Article in English | MEDLINE | ID: mdl-34664874

ABSTRACT

ABSTRACT: International evidence-based guidelines recommend self-management support for stroke survivors to improve their health outcomes. We developed a 4-week nurse-led stroke self-management programme (SSMP) and conducted a randomised controlled trial to assess its effects. This paper reports the findings of a qualitative study nested within the randomised controlled trial to explore stroke survivors' experiences of SSMP participation. Semi-structured interviews were conducted with all adult participants who were clinically diagnosed with a first or recurrent ischaemic or haemorrhagic stroke, residing at home, communicable in Cantonese, had a Montreal Cognitive Assessment score below the second percentile, and participated in at least 1 SSMP session. All interviews were conducted in Cantonese, lasted approximately 45 minutes, and were audio-recorded. Interview data were transcribed verbatim and analysed thematically. Sixty-four stroke survivors (mean age 66.33 years, SD 12.34) were recruited, and 59 were interviewed via phone immediately after completion of SSMP. Three themes were derived. Overall, participants were satisfied with the SSMP. Their understanding of self-management was improved, and they recognised its importance in recovery. Their confidence in self-management was also enhanced through the use of multifaceted strategies. Suggestions were made to enhance their participation experiences, including increased home visits and group sessions, making group session attendance optional and arranging them more accessibly, meeting the survivors who shared their survival experiences in the videos, and access to the videos online. This study concurred that the SSMP enhanced stroke survivors' self-efficacy in self-management. Rearrangement of the programme format and enhancements in accessibility could be further examined to enable more effective stroke self-management.


Subject(s)
Independent Living/psychology , Self-Management/psychology , Stroke/nursing , Survivors/psychology , Adult , Aged , Aged, 80 and over , Female , Humans , Independent Living/injuries , Interviews as Topic/methods , Male , Middle Aged , Nursing Theory , Program Evaluation/methods , Program Evaluation/statistics & numerical data , Qualitative Research , Self-Management/methods , Self-Management/statistics & numerical data , Stroke/psychology , Stroke Rehabilitation/nursing , Stroke Rehabilitation/psychology , Stroke Rehabilitation/standards , Survivors/statistics & numerical data
6.
Stroke ; 52(10): e675-e700, 2021 10.
Article in English | MEDLINE | ID: mdl-34348470

ABSTRACT

The American Heart Association/American Stroke Association released the adult stroke rehabilitation and recovery guidelines in 2016. A working group of stroke rehabilitation experts reviewed these guidelines and identified a subset of recommendations that were deemed suitable for creating performance measures. These 13 performance measures are reported here and contain inclusion and exclusion criteria to allow calculation of rates of compliance in a variety of settings ranging from acute hospital care to postacute care and care in the home and outpatient setting.


Subject(s)
Stroke Rehabilitation/standards , Acute Disease/therapy , Ambulatory Care , American Heart Association , Health Care Sector , Home Care Services , Humans , Organizations , Rehabilitation Centers , United States
7.
Medicine (Baltimore) ; 100(23): e26254, 2021 Jun 11.
Article in English | MEDLINE | ID: mdl-34115016

ABSTRACT

BACKGROUND: In recent years, with the development of medical technology and the increase of inter-disciplinary cooperation technology, new methods in the field of artificial intelligence medicine emerge in an endless stream. Brain-computer interface (BCI), as a frontier technology of multidisciplinary integration, has been widely used in various fields. Studies have shown that BCI-assisted training can improve upper limb function in stroke patients, but its effect is still controversial and lacks evidence-based evidence, which requires further exploration and confirmation. Therefore, the main purpose of this paper is to systematically evaluate the efficacy of different BCI-assisted training on upper limb function recovery in stroke patients, to provide a reference for the application of BCI-assisted technology in stroke rehabilitation. METHODS: We will search PubMed, Web of Science, The Cochrane Library, Chinese National Knowledge Infrastructure Database, Wanfang Data, Weipu Electronics, and other databases (from the establishment to February 2021) for full text in Chinese and English. Randomized controlled trials were collected to examine the effect of BCI-assisted training on upper limb functional recovery in stroke patients. We will consider inclusion, select high-quality articles for data extraction and analysis, and summarize the intervention effect of BCI-assisted training on the upper limb function of stroke patients. Two reviewers will screen titles, abstracts, and full texts independently according to inclusion criteria; Data extraction and risk of bias assessment were performed in the included studies. We will use a hierarchy of recommended assessment, development, and assessment methods to assess the overall certainty of the evidence and report findings accordingly. Endnote X8 will be applied in selecting the study, Review Manager 5.3 will be applied in analyzing and synthesizing. RESULTS: The results will provide evidence for judging whether BCI is effective and safe in improving upper limb function in patients with stroke. CONCLUSION: Our study will provide reliable evidence for the effect of BCI technology on the improvement of upper limb function in stroke patients. PROSPERO REGISTRATION NUMBER: CRD42021250378.


Subject(s)
Brain-Computer Interfaces/standards , Clinical Protocols , Stroke Rehabilitation/standards , Upper Extremity/physiopathology , Brain-Computer Interfaces/psychology , Humans , Meta-Analysis as Topic , Recovery of Function , Stroke/complications , Stroke Rehabilitation/methods , Systematic Reviews as Topic
8.
BMC Neurol ; 21(1): 76, 2021 Feb 17.
Article in English | MEDLINE | ID: mdl-33596841

ABSTRACT

BACKGROUND: In contrast to the hospital setting, today little work has been directed to the definition, measurement, and improvement of the quality of out-patient medical and therapeutic care. We developed a set of indicators to measure the quality of out-patient neuropsychological therapy after stroke. METHODS: The indicators cover core and interdisciplinary aspects of out-patient neuropsychological work such as mediation of patients into social care in case of need. Selection of the quality-indicators was done together with a consensus group of out-patient therapists and supported by evidence, validity, reliability as well as estimated relevance and variability with the quality of care. The set of indicators was further tested in a retrospective cohort study. Anonymous data of 104 patients were collected from out-patient clinical records of five clinics between November 2017 and April 2018. Associations between process and outcome quality were estimated exploitatively. RESULTS: Results allowed for the identification of areas with greater variability in the quality of process care and indicated that attention training as recommended by current guidelines had the lowest overall rate for meeting the quality-aim (met in 44% of the cases). This was followed by time < 1 month until the start of therapy (63% met) and mediation into social care in case of need (65% met). We further observed that overall quality and involving relatives in the therapy was associated with higher rates of professional reintegration (p-value = 0.03). However, the need for mediation into social care was associated with a reduced chance for successful professional reintegration (p-value = 0.009). CONCLUSION: In conclusion, we describe a first set of quality indicators which cover different aspects of out-patient neuropsychological therapy and sufficient variability with care. First data further suggests that meeting the specified quality aims may indeed have relevant effects on outcomes.


Subject(s)
Ambulatory Care/standards , Psychotherapy/standards , Stroke Rehabilitation/standards , Stroke/therapy , Adult , Aged , Aged, 80 and over , Consensus , Female , Germany , Humans , Male , Middle Aged , Neuropsychology , Outcome and Process Assessment, Health Care , Pilot Projects , Quality Indicators, Health Care , Reproducibility of Results , Retrospective Studies , Stroke/physiopathology , Stroke/psychology
9.
Stroke ; 52(2): 761-769, 2021 01.
Article in English | MEDLINE | ID: mdl-33430635

ABSTRACT

Dose articulation is a universal issue of intervention development and testing. In stroke recovery, dose of a nonpharmaceutical intervention appears to influence outcome but is often poorly reported. The challenges of articulating dose in nonpharmacological stroke recovery research include: (1) the absence of specific internationally agreed dose reporting guidelines; (2) inadequate conceptualization of dose, which is multidimensional; and (3) unclear and inconsistent terminology that incorporates the multiple dose dimensions. To address these challenges, we need a well-conceptualized and consistent approach to dose articulation that can be applied across stroke recovery domains to stimulate critical thinking about dose during intervention development, as well as promote reporting of planned intervention dose versus actually delivered dose. We followed the Design Research Paradigm to develop a framework that guides how to articulate dose, conceptualizes the multidimensional nature and systemic linkages between dose dimensions, and provides reference terminology for the field. Our framework recognizes that dose is multidimensional and comprised of a duration of days that contain individual sessions and episodes that can be active (time on task) or inactive (time off task), and each individual episode can be made up of information about length, intensity, and difficulty. Clinical utility of this framework was demonstrated via hypothetical application to preclinical and clinical domains of stroke recovery. The suitability of the framework to address dose articulation challenges was confirmed with an international expert advisory group. This novel framework provides a pathway for better articulation of nonpharmacological dose that will enable transparent and accurate description, implementation, monitoring, and reporting, in stroke recovery research.


Subject(s)
Recovery of Function , Stroke Rehabilitation/standards , Stroke/therapy , Humans , Patient Education as Topic , Stroke/complications
10.
PLoS One ; 16(1): e0245874, 2021.
Article in English | MEDLINE | ID: mdl-33513170

ABSTRACT

OBJECTIVE: One of the greatest challenges in clinical trial design is dealing with the subjectivity and variability introduced by human raters when measuring clinical end-points. We hypothesized that robotic measures that capture the kinematics of human movements collected longitudinally in patients after stroke would bear a significant relationship to the ordinal clinical scales and potentially lead to the development of more sensitive motor biomarkers that could improve the efficiency and cost of clinical trials. MATERIALS AND METHODS: We used clinical scales and a robotic assay to measure arm movement in 208 patients 7, 14, 21, 30 and 90 days after acute ischemic stroke at two separate clinical sites. The robots are low impedance and low friction interactive devices that precisely measure speed, position and force, so that even a hemiparetic patient can generate a complete measurement profile. These profiles were used to develop predictive models of the clinical assessments employing a combination of artificial ant colonies and neural network ensembles. RESULTS: The resulting models replicated commonly used clinical scales to a cross-validated R2 of 0.73, 0.75, 0.63 and 0.60 for the Fugl-Meyer, Motor Power, NIH stroke and modified Rankin scales, respectively. Moreover, when suitably scaled and combined, the robotic measures demonstrated a significant increase in effect size from day 7 to 90 over historical data (1.47 versus 0.67). DISCUSSION AND CONCLUSION: These results suggest that it is possible to derive surrogate biomarkers that can significantly reduce the sample size required to power future stroke clinical trials.


Subject(s)
Movement , Recovery of Function , Robotics/methods , Stroke Rehabilitation/standards , Stroke/physiopathology , Adult , Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , Neurologic Examination/methods , Neurologic Examination/standards , Stroke Rehabilitation/methods
11.
Res Nurs Health ; 44(1): 213-225, 2021 02.
Article in English | MEDLINE | ID: mdl-33341958

ABSTRACT

Caregiving in stroke results in severe physical, psychological, and social impacts on the caregiver. Over the past few years, researchers have explored the use of mHealth technologies to support healthcare-related activities due to their ability to provide real-time care at any given place or time. The purpose of this content review is to investigate mHealth apps in supporting stroke caregiving engagement based on three aspects: motivation, value, and satisfaction. We searched app stores and repositories for apps related to stroke caregiving published up to September 2020. Extracted apps were reviewed and filtered using inclusion criteria, and then downloaded onto compatible devices to determine eligibility. Results were compared with evidence-based frameworks to identify the ability of these apps in engaging and supporting the caregiver. Forty-seven apps were included in this review that enabled caregivers to support their needs, such as adjustment to new roles and relationships, involvement in care and caring for oneself using several different functionalities. These functionalities include information resources, risk assessment, remote monitoring, data sharing, reminders and so on. However, no single app was identified that focuses on all aspects of stroke caregiving. We also identified several challenges faced by users through their reviews and the factors associated with value and satisfaction. Our findings can add to the knowledge of existing mHealth technologies and their functionalities to support stroke caregiving needs, and the importance of considering user engagement in the design. They can be used by developers and researchers looking to design better mHealth apps for stroke caregiving.


Subject(s)
Caregivers/psychology , Social Participation/psychology , Stroke Rehabilitation/standards , Telemedicine/standards , Caregivers/statistics & numerical data , Humans , Stroke Rehabilitation/methods , Stroke Rehabilitation/statistics & numerical data , Telemedicine/methods , Telemedicine/statistics & numerical data
12.
J Alzheimers Dis ; 79(2): 905-916, 2021.
Article in English | MEDLINE | ID: mdl-33361596

ABSTRACT

BACKGROUND: Patient dissatisfaction with stroke care is associated with poor self-rated health and unmet care needs. Dementia patients' satisfaction with stroke care is understudied. OBJECTIVE: To compare satisfaction with stroke care in patients with and without dementia. METHODS: This longitudinal cohort study included 5,932 dementia patients (2007-2017) who suffered a first stroke after dementia diagnosis and 39,457 non-dementia stroke patients (2007-2017). Data were retrieved by linking the Swedish Stroke Register, the Swedish Dementia Register, the Swedish National Patient Register, and the Swedish Prescribed Drug Register. The association between dementia and satisfaction was analyzed with ordinal logistic regression. RESULTS: When dementia patients answered themselves, they reported significantly lower odds of satisfaction with acute stroke care (OR: 0.71; 95% CI: 0.60-0.85), healthcare staff's attitude (OR: 0.79; 95% CI: 0.66-0.96), communication with doctors (OR: 0.78; 95% CI: 0.66-0.92), stroke information (OR: 0.62; 95% CI: 0.52-0.74); but not regarding inpatient rehabilitation (OR: 0.93; 95% CI: 0.75-1.16), or outpatient rehabilitation (OR: 0.93; 95% CI: 0.73-1.18). When patients answered with caregivers' help, the association between dementia status and satisfaction remained significant in all items. Subgroup analyses showed that patients with Alzheimer's disease and mixed dementia reported lower odds of satisfaction with acute care and healthcare staff's attitude when they answered themselves. CONCLUSION: Patients with dementia reported lower satisfaction with stroke care, revealing unfulfilled care needs among dementia patients, which are possibly due to different (or less) care, or because dementia patients require adaptations to standard care.


Subject(s)
Alzheimer Disease/complications , Dementia/complications , Patient Satisfaction/statistics & numerical data , Stroke Rehabilitation/standards , Activities of Daily Living/psychology , Aged, 80 and over , Alzheimer Disease/psychology , Case-Control Studies , Dementia/psychology , Female , Humans , Longitudinal Studies , Male , Registries , Stroke/complications , Stroke/therapy , Sweden
13.
Neurosci Lett ; 743: 135558, 2021 01 19.
Article in English | MEDLINE | ID: mdl-33352282

ABSTRACT

Transcallosal inhibition (TCI) is a measure of between-hemisphere inhibitory control that can be evaluated with the ipsilateral silent period (iSP) transcranial magnetic stimulation (TMS) paradigm. The study of iSP for the lower extremity has been limited possibly due to the close orientation of the lower extremity motor representations. Change in TCI can provide insights into pathophysiological mechanisms underlying the asymmetry in corticomotor excitability in stroke. Here, we describe a method for iSP quantification and report reliability of iSP parameters for the tibialis anterior (TA) muscle in stroke. 26 individuals with stroke attended three sessions where single pulse TMS was used to measure TCI from the lesioned to non-lesioned hemisphere. A double cone coil was used for stimulating the ipsilateral motor cortex while the participant maintained an isometric contraction of the non-paretic TA. Absolute and relative reliability were computed for iSP latency, duration and area. iSP latency showed the lowest measurement error (absolute reliability) and iSP latency, duration and area showed good relative reliability (intraclass correlation coefficients > 0.6). This study suggests that iSP parameters for the tibialis anterior are reliable and attempts to provide a guideline for evaluating TCI for the lower extremity in stroke and other clinical populations.


Subject(s)
Corpus Callosum/physiology , Lower Extremity/physiology , Motor Cortex/physiology , Neural Inhibition/physiology , Stroke Rehabilitation/standards , Transcranial Magnetic Stimulation/standards , Adult , Aged , Electromyography/methods , Electromyography/standards , Female , Humans , Male , Middle Aged , Reproducibility of Results , Stroke/physiopathology , Stroke/therapy , Stroke Rehabilitation/methods , Transcranial Magnetic Stimulation/methods
14.
Transl Stroke Res ; 12(1): 65-71, 2021 02.
Article in English | MEDLINE | ID: mdl-32583333

ABSTRACT

Vagus nerve stimulation (VNS) paired with rehabilitative training enhances recovery of function in models of stroke and is currently under investigation for use in chronic stroke patients. Dosing is critical in translation of pharmacological therapies, but electrical stimulation therapies often fail to comprehensively explore dosing parameters in preclinical studies. Varying VNS parameters has non-monotonic effects on plasticity in the central nervous system, which may directly impact efficacy for stroke. We sought to optimize stimulation intensity to maximize recovery of motor function in a model of ischemic stroke. The study design was preregistered prior to beginning data collection (DOI: https://doi.org/10.17605/OSF.IO/BMJEK ). After training on an automated assessment of forelimb function and receiving an ischemic lesion in motor cortex, rats were separated into groups that received rehabilitative training paired with VNS at distinct stimulation intensities (sham, 0.4 mA, 0.8 mA, or 1.6 mA). Moderate-intensity VNS at 0.8 mA enhanced recovery of function compared with all other groups. Neither 0.4 mA nor 1.6 mA VNS was sufficient to improve functional recovery compared with equivalent rehabilitation without VNS. These results demonstrate that moderate-intensity VNS delivered during rehabilitation improves recovery and defines an optimized intensity paradigm for clinical implementation of VNS therapy.


Subject(s)
Recovery of Function/physiology , Stroke Rehabilitation/methods , Stroke Rehabilitation/standards , Stroke/therapy , Vagus Nerve Stimulation/methods , Vagus Nerve Stimulation/standards , Animals , Female , Rats , Rats, Sprague-Dawley , Stroke/diagnosis , Stroke/physiopathology
15.
Top Stroke Rehabil ; 28(3): 198-206, 2021 04.
Article in English | MEDLINE | ID: mdl-32787668

ABSTRACT

BACKGROUND: Stroke can affect a person's ability to drive a motor vehicle. In Australia, there is a 4-week restriction in driving after stroke and a 2-week restriction after transient ischemic attack. Concerns exist as to whether people discharged home from the acute setting receive education about these driving restrictions. OBJECTIVES: This study sought to investigate health professionals' knowledge about, and responsibilities for patients return-to-driving (RTD) education after stroke and TIA. METHODS: A cross-sectional online survey was designed and included questions about health professional demographic characteristics and knowledge and opinions of RTD guidelines. An open-ended question at the end of the survey enabled respondents to provide additional, free text information. Descriptive analyses were used to describe respondents' demography and characteristics. Chi-square analysis was used to compare responses across the different professional groups. Significance was tested using a p-value of 0.05. Data obtained from the free text question were analyzed through an inductive thematic approach. RESULTS: A total of 455 health professionals responded to the survey, with 45% being occupational therapists. Only 22% of health professionals correctly selected the 4-week restriction period after stroke and 27% selected the 2-week restriction period for those with TIA. Occupational therapists were identified by 85% of respondents as the profession responsible for providing RTD education, followed by doctors (72%). Health professionals lack clarity in RTD guidelines and often defer the responsibility of managing RTD to others. CONCLUSIONS: Education of health professionals in RTD guidelines is recommended to improve the processes of care after stroke.


Subject(s)
Automobile Driving/standards , Health Knowledge, Attitudes, Practice , Occupational Therapists/psychology , Occupational Therapy/methods , Physicians/psychology , Stroke Rehabilitation/standards , Stroke/therapy , Adult , Australia , Cross-Sectional Studies , Female , Humans , Male , Patient Discharge/statistics & numerical data , Perception , Stroke Rehabilitation/psychology , Surveys and Questionnaires
16.
Toxins (Basel) ; 14(1)2021 12 23.
Article in English | MEDLINE | ID: mdl-35050990

ABSTRACT

Identifying patients who can gain minimal clinically important difference (MCID) in active motor function in the affected upper extremity (UE) after a botulinum toxin A (BoNT-A) injection for post-stroke spasticity is important. Eighty-eight participants received a BoNT-A injection in the affected UE. Two outcome measures, Fugl-Meyer Assessment Upper Extremity (FMA-UE) and Motor Activity Log (MAL), were assessed at pre-injection and after 24 rehabilitation sessions. We defined favorable response as an FMA-UE change score ≥5 or MAL change score ≥0.5.Statistical analysis revealed that the time since stroke less than 36 months (odds ratio (OR) = 4.902 (1.219-13.732); p = 0.023) was a significant predictor of gaining MCID in the FMA-UE. Medical Research Council scale -proximal UE (OR = 1.930 (1.004-3.710); p = 0.049) and post-injection duration (OR = 1.039 (1.006-1.074); p =0.021) were two significant predictors of MAL amount of use. The time since stroke less than 36 months (OR = 3.759 (1.149-12.292); p = 0.028), naivety to BoNT-A (OR = 3.322 (1.091-10.118); p = 0.035), and education years (OR = 1.282 (1.050-1.565); p = 0.015) were significant predictors of MAL quality of movement. The findings of our study can help optimize BoNT-A treatment planning.


Subject(s)
Arm/physiopathology , Botulinum Toxins, Type A/pharmacology , Muscle Spasticity/drug therapy , Recovery of Function , Stroke Rehabilitation/standards , Stroke/drug therapy , Adult , Female , Humans , Male , Middle Aged , Stroke Rehabilitation/statistics & numerical data
17.
Scand J Occup Ther ; 28(5): 375-383, 2021 Jul.
Article in English | MEDLINE | ID: mdl-32689853

ABSTRACT

BACKGROUND: About half of those that have had stroke in working age return to work (RTW). Few rehabilitation programmes exist focussing RTW after stroke. AIM: To produce a clear replicable description of the ReWork-Stroke rehabilitation programme targeting RTW for people of working age who have had stroke. MATERIALS AND METHODS: The Template for Intervention Description and Replication 12 item checklist was used to describe the ReWork-Stroke programme developed 2013-2014. This paper presents the development, rationale and processes in the programme to enable replication and provide evidence for implementation. RESULTS: Occupational therapists (OTs) skilled in stroke rehabilitation contribute knowledge about consequences of stroke and coordinate stakeholders involved. The ReWork-Stroke is person-centred, includes individual plans and generic components, consists of a preparation and a work trial phase. During the preparation phase, resources and hindrances for RTW are mapped and a plan for work trial is elaborated. During the work trial phase, the intervention is located at the workplace. The OT conducts recurrent follow-ups and collaborates with employers/co-workers. CONCLUSIONS: A person-centred programme has advantages in its flexibility to meet different needs between people and by this thorough description of ReWork-Stroke, others can replicate the programme and its fidelity and evidence can be strengthened.


Subject(s)
Checklist/standards , Patient Participation/methods , Return to Work , Stroke Rehabilitation/methods , Stroke Rehabilitation/standards , Work Engagement , Work Performance/education , Adult , Female , Humans , Male , Middle Aged , Sweden
18.
Arch Phys Med Rehabil ; 102(1): 106-114, 2021 01.
Article in English | MEDLINE | ID: mdl-32750375

ABSTRACT

OBJECTIVE: To combine items from the Functional Independence Measure, Minimum Data Set (MDS) 2.0, and the Outcome and Assessment Information Set (OASIS)-B to reliably measure cognition across postacute care settings and facilitate future studies of patient cognitive recovery. DESIGN: Rasch analysis of data from a prospective, observational cohort study. SETTING: Postacute care inclusive of inpatient rehabilitation facilities, skilled nursing facilities, and home health agencies. PARTICIPANTS: Patients (N=147) receiving rehabilitation services. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Functional Independence Measure, MDS 2.0, and the OASIS-B. RESULTS: Six cognition items demonstrated good construct validity with no misfitting items, unidimensionality, good precision (person separation reliability, 0.95), and an item hierarchy that reflected a clinically meaningful continuum of cognitive challenge. CONCLUSIONS: This is the first attempt to combine the cognition items from the 3 historically, federally mandated assessments to create a common metric for cognition. These 6 items could be adopted as standardized patient assessment data elements to improve cognitive assessment across postacute care settings.


Subject(s)
Cognition Disorders/diagnosis , Disability Evaluation , Stroke Rehabilitation/methods , Subacute Care/methods , Surveys and Questionnaires/standards , Activities of Daily Living , Aged , Aged, 80 and over , Female , Humans , Male , Prospective Studies , Psychometrics , Recovery of Function , Reproducibility of Results , Socioeconomic Factors , Stroke Rehabilitation/standards , Subacute Care/standards , United States
19.
Ned Tijdschr Geneeskd ; 1642020 12 10.
Article in Dutch | MEDLINE | ID: mdl-33332061

ABSTRACT

Application of movement technology in the rehabilitation of neurological disorders has gained a firm position within a short time span, but the effectiveness of many technological innovations is still poorly supported by evidence. Should this burst of movement technology be considered a hype or is it offering realistic hope? This perspective focuses on motor rehabilitation after unilateral stroke and addresses the value of rehabilitation robots, virtual-reality training, peripheral neurostimulation, and brain stimulation. Current rehabilitation robots offer added value compared to conventional training, but only early after stroke for patients who are not yet able to walk independently. The effects of peripheral neurostimulation or brain stimulation are still hard to prove or relatively small. Virtual-reality training seems to be most promising for regaining motor skills, particularly when adjusted to individual capacities. Overall, functional benefits of movement technology in the rehabilitation of neurological disorders keep the middle between hype and hope.


Subject(s)
Exercise Therapy/standards , Stroke Rehabilitation/standards , Virtual Reality , Equipment Design , Humans , Recovery of Function , Robotics , Stroke/therapy
20.
Lancet ; 396(10260): 1452-1462, 2020 10 31.
Article in English | MEDLINE | ID: mdl-33129396

ABSTRACT

The WHO Rehabilitation 2030 agenda recognises the importance of rehabilitation in the value chain of quality health care. Developing and delivering cost-effective, equitable-access rehabilitation services to the right people at the right time is a challenge for health services globally. These challenges are amplified in low-income and middle-income countries (LMICs), in which the unmet need for rehabilitation and recovery treatments is high. In this Series paper, we outline what is happening more broadly as part of the WHO Rehabilitation 2030 agenda, then focus on the specific challenges to development and implementation of effective stroke rehabilitation services in LMICs. We use stroke rehabilitation clinical practice guidelines from both high-income countries and LMICs to highlight opportunities for rapid uptake of evidence-based practice. Finally, we call on educators and the stroke rehabilitation clinical, research, and not-for-profit communities to work in partnership for greater effect and to accelerate progress.


Subject(s)
Evidence-Based Practice , Stroke Rehabilitation/standards , Developing Countries , Guidelines as Topic , Humans , Self-Help Devices/supply & distribution , Stroke Rehabilitation/methods , World Health Organization
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