ABSTRACT
Using a stepwise assessment of the exposure of Korean consumers to acesulfame K and sucralose, theoretical maximum daily intakes of the sweeteners were calculated using the Budget screening method, which resulted in values greater than the acceptable daily intakes (ADIs). Accordingly, the daily intakes of the sweeteners based on food consumption data and concentrations determined by instrumental analysis of 605 food samples were estimated for the more refined approach. The estimated daily intakes (EDIs) of all ordinary consumers were lower than the ADI, which was considered safe. However, for infants and 95th percentile high-level consumers (especially those who choose sucralose-containing foods), the EDIs of sucralose were very close to and higher than the ADI. Therefore, the sucralose concentration in sweetened beverages should be reduced; this would benefit the health of both high-level consumers and infants.
Subject(s)
Diet , Models, Biological , Non-Nutritive Sweeteners/administration & dosage , Sucrose/analogs & derivatives , Thiazines/administration & dosage , Adult , Age Factors , Algorithms , Beverages/adverse effects , Beverages/analysis , Child , Consumer Product Safety , Diet/adverse effects , Diet/ethnology , Diet Surveys , Female , Food Analysis , Humans , Infant , Male , Non-Nutritive Sweeteners/analysis , Non-Nutritive Sweeteners/poisoning , Nutrition Policy , Republic of Korea , Sucrose/administration & dosage , Sucrose/analysis , Sucrose/poisoning , Thiazines/analysis , Thiazines/poisoningSubject(s)
Acidosis/veterinary , Bees , Lactates , Sucrose/poisoning , Acidosis/diagnosis , Acidosis/etiology , Animals , CattleABSTRACT
The sorbitol pathway has been suggested as a biochemical mechanism for peripheral neuropathy in diabetes, due to accumulation of osmotically active polyols which cause endoneurial edema. The purpose of this study was to compare endoneurial fluid pressure (EFP) in the peripheral nerves of rats in three experimental models: streptozotocin diabetes, galactose neuropathy, and sucrose intoxication. Endoneurial fluid pressure was measured in 27 diabetic rats at intervals of 4 to 51 weeks after inoculation with streptozotocin and in ten control rats. Elevated fluid pressure was observed in only two diabetic animals, and there was no significant difference in mean EFP between test animals and controls. By contrast, elevated EFP was found in 9 of 11 rats who received a 68% sucrose diet for 48-51 weeks. The mean EFP in these animals was approximately twice normal, and sucrose intoxication thus appears to be a more effective model than streptozotocin diabetes for nerve edema associated with the sorbitol pathway.
