Subject(s)
Cyclophosphamide/therapeutic use , Doxorubicin/therapeutic use , Galactitol/analogs & derivatives , Lung Neoplasms/drug therapy , Platinum/therapeutic use , Sugar Alcohols/analogs & derivatives , Adenocarcinoma/drug therapy , Adenocarcinoma/mortality , Adult , Aged , Carcinoma, Squamous Cell/drug therapy , Carcinoma, Squamous Cell/mortality , Drug Evaluation , Drug Synergism , Drug Therapy, Combination , Galactitol/therapeutic use , Humans , Lung Neoplasms/mortality , Male , Middle AgedABSTRACT
alpha, omega-Disubstituted derivatives of 2,3-anhydro-DL-threitol (2), 2,3-anhydroerythritol (4), 2,3:4,5-dianhydrogalactitol (8), and 2,3:4,5-dianhydroallitol (12) have been synthesised by epoxidation of the appropriate alkeness and dienes. Benzyloxy carbonyl groups were used for protecting the primary hydroxyl groups during epoxidation.
Subject(s)
Alkylating Agents , Erythritol/analogs & derivatives , Galactitol/analogs & derivatives , Sugar Alcohols , Sugar Alcohols/analogs & derivatives , Alkylating Agents/chemical synthesis , Erythritol/chemical synthesis , Ethers, Cyclic/chemical synthesis , Galactitol/chemical synthesis , Magnetic Resonance Spectroscopy , Methods , Structure-Activity Relationship , Sugar Alcohols/chemical synthesisABSTRACT
The effect of dianhydrodulcithol (DAD) administered in a dose of 5 mg/kg on the number of plaque-forming cells (PFC) in spleens and on the titre of hemolytic antibodies in the sera of rats immunised with sheep red blood cells (SRBC) have been examined. The compound elicited a short-lasting suppressive effect when applied after immunisation; the number of PFC decreased two days after treatment while 5 days after drug administration increased as compared to the untreated animals. Treatment prior to immunisation proved to be ineffective. The titre of circulating antibodies showed changes similar although of lesser extent. Five days following treatment marked infiltration of plasmacytes was present in the axillary lymph nodes. Rats bearing transplantable Guérin tumor showed similar changes in immune response as the tumor free animals following DAD treatment.
Subject(s)
Galactitol , Immunity/drug effects , Neoplasms, Experimental/immunology , Sugar Alcohols , Animals , Antibody Formation/drug effects , Antibody-Producing Cells/drug effects , Epoxy Compounds/pharmacology , Female , Galactitol/analogs & derivatives , Galactitol/pharmacology , Hemolysin Proteins/analysis , Hemolytic Plaque Technique , Lymph Nodes/pathology , Male , Neoplasms, Experimental/drug therapy , Neoplasms, Experimental/pathology , Organ Size/drug effects , Plasma Cells/pathology , Rats , Spleen/pathology , Sugar Alcohols/analogs & derivativesABSTRACT
The course of intracerebral lymphocytic choriomeningitis (LCM) virus infection was studied in mice treated simultaneously with dianhydrodulcitol (DAD) and phytohaemagglutinin (PHA). Earlier experiments revealed that DAD decreased and PHA enhanced the cellular immune response of mice to LCM virus infection. On applying the treatments simultaneously they inhibited each other and neither the decreasing effect of DAD nor the enhancing effect of PHA on the cellular immune response could be observed.
