Subject(s)
Melanoma/epidemiology , Nail Diseases/epidemiology , Skin Neoplasms/epidemiology , Sweat Gland Neoplasms/epidemiology , Sweat Glands/pathology , Aged , Aged, 80 and over , Female , Foot , Hand , Humans , Male , Margins of Excision , Melanoma/etiology , Melanoma/pathology , Melanoma/surgery , Middle Aged , Nail Diseases/pathology , Nail Diseases/surgery , Nails/pathology , Nails/surgery , Skin/pathology , Skin Neoplasms/etiology , Skin Neoplasms/pathology , Skin Neoplasms/surgery , Sweat Gland Neoplasms/etiology , Sweat Gland Neoplasms/pathology , Sweat Gland Neoplasms/surgery , Sweat Glands/surgerySubject(s)
Buttocks/pathology , Eccrine Porocarcinoma/pathology , Keratosis, Seborrheic/diagnosis , Skin/pathology , Sweat Gland Neoplasms/pathology , Aged, 80 and over , Eccrine Porocarcinoma/diagnosis , Eccrine Porocarcinoma/etiology , Eccrine Porocarcinoma/surgery , Female , Humans , Keratosis, Seborrheic/complications , Keratosis, Seborrheic/pathology , Mohs Surgery , Sweat Gland Neoplasms/diagnosis , Sweat Gland Neoplasms/etiology , Sweat Gland Neoplasms/surgeryABSTRACT
Eccrine poroma presents as a single, symptomless erythematous papule in areas with a high density of eccrine sweat glands. Although rare, eccrine poromas can present as multiple lesions, otherwise known as eccrine poromatosis. The etiology of eccrine poromatosis is unclear. We present two cases of eccrine poromatosis in patients who had undergone chemotherapy, radiation therapy, and stem cell transplant. This case report serves to raise awareness of this condition and highlight its association with malignancies and their treatment.
Subject(s)
Antineoplastic Agents/adverse effects , Poroma/etiology , Radiotherapy/adverse effects , Sweat Gland Neoplasms/etiology , Aged , Drug-Related Side Effects and Adverse Reactions , Humans , Lymphoma, Large B-Cell, Diffuse/complications , Lymphoma, Large B-Cell, Diffuse/drug therapy , Lymphoma, Mantle-Cell/complications , Lymphoma, Mantle-Cell/drug therapy , Male , Middle Aged , Poroma/pathology , Prostatic Neoplasms/complications , Prostatic Neoplasms/radiotherapy , Sweat Gland Neoplasms/pathologyABSTRACT
Malignant sweat gland neoplasms are a confusing area within dermatopathology, with many entities reported under several designations in the literature. This review describes the key clinical and histopathologic features of select malignant adnexal neoplasms, including porocarcinoma, papillary carcinoma, adenoid cystic carcinoma, cribriform carcinoma, apocrine hidradenocarcinoma, malignant mixed tumor of the skin, syringoid carcinoma, cylindrocarcinoma, spiradenocarcinoma, mucinous carcinoma, polymorphous sweat gland carcinoma, microcystic adnexal carcinoma, secretory carcinoma of the skin, and primary cutaneous signet ring cell carcinoma. For entities with overlapping features, differential diagnoses are discussed.
Subject(s)
Sweat Gland Neoplasms/diagnosis , Biopsy , Diagnosis, Differential , Disease Management , Humans , Immunohistochemistry , Neoplasm Grading , Neoplasm Staging , Sweat Gland Neoplasms/etiology , Sweat Gland Neoplasms/therapySubject(s)
Calcinosis/diagnosis , Down Syndrome/complications , Keratosis/diagnosis , Sweat Gland Neoplasms/diagnosis , Syringoma/diagnosis , Calcinosis/etiology , Calcinosis/pathology , Child , Face , Female , Humans , Keratosis/etiology , Keratosis/pathology , Skin/pathology , Sweat Gland Neoplasms/etiology , Sweat Gland Neoplasms/pathology , Syringoma/etiology , Syringoma/pathologySubject(s)
Carcinoma, Skin Appendage/diagnosis , Sunlight/adverse effects , Sweat Gland Neoplasms/diagnosis , Carcinoma, Skin Appendage/etiology , Carcinoma, Skin Appendage/pathology , Carcinoma, Skin Appendage/surgery , Eccrine Glands/pathology , Eccrine Glands/radiation effects , Eccrine Glands/surgery , Female , Humans , Lacrimal Apparatus/pathology , Lacrimal Apparatus/radiation effects , Lacrimal Apparatus/surgery , Middle Aged , Sweat Gland Neoplasms/etiology , Sweat Gland Neoplasms/pathology , Sweat Gland Neoplasms/surgery , Treatment OutcomeSubject(s)
Adenocarcinoma/etiology , Anus Neoplasms/etiology , Crohn Disease/complications , Rectal Fistula/etiology , Sweat Gland Neoplasms/etiology , Adenocarcinoma/diagnosis , Adenocarcinoma/secondary , Adenocarcinoma/surgery , Adult , Antineoplastic Agents/therapeutic use , Antineoplastic Combined Chemotherapy Protocols/administration & dosage , Anus Neoplasms/drug therapy , Anus Neoplasms/surgery , Biomarkers, Tumor/analysis , Colostomy , Crohn Disease/surgery , Fluorouracil/administration & dosage , Humans , Leucovorin/administration & dosage , Lymphatic Metastasis , Male , Neoadjuvant Therapy , Organoplatinum Compounds/administration & dosage , Postoperative Complications , Sweat Gland Neoplasms/drug therapy , Sweat Gland Neoplasms/surgerySubject(s)
Liver Transplantation/adverse effects , Skin/pathology , Sweat Gland Neoplasms/etiology , Syringoma/etiology , Aged , Biopsy , Female , Humans , Immunocompromised Host , Immunosuppressive Agents/adverse effects , Skin/immunology , Sweat Gland Neoplasms/immunology , Sweat Gland Neoplasms/pathology , Syringoma/immunology , Syringoma/pathologySubject(s)
Carcinoma, Skin Appendage/etiology , Head and Neck Neoplasms/etiology , Neoplasms, Radiation-Induced/etiology , Precursor Cell Lymphoblastic Leukemia-Lymphoma/radiotherapy , Scalp , Sweat Gland Neoplasms/etiology , Adult , Apocrine Glands , Carcinoma, Skin Appendage/pathology , Female , Head and Neck Neoplasms/pathology , Humans , Neoplasms, Radiation-Induced/pathology , Radiotherapy/adverse effects , Sweat Gland Neoplasms/pathologyABSTRACT
Syringomas are benign adnexal tumors with distinct histopathologic features, including the characteristic comma ("tadpole") shaped tail comprised of dilated, cystic eccrine ducts. Clinically, syringomas typically present in adolescent females predominantly in the periorbital region. They may present as solitary or multiple lesions, and more rare sites of involvement include the genitals, palms, scalp, and the chest. Over the past 50 years, there have been >800 reported cases of syringoma either alone or in conjunction with a systemic syndrome, most commonly Down syndrome. The primary aim of this systematic review is to discuss the clinical features and associations of syringomas with a focus on the patient with multiple syringomas. Its secondary aims are to explore pathophysiology with a focus on multiple syringomas and provide comprehensive data on both traditional and novel treatments. Importantly, multiple syringomas present across a broad clinical spectrum. Though noted in many textbooks to be related to tumor syndromes, the association of syringomas with inherited tumor syndromes is only rarely reported in the literature. Despite multiple reported cases of syringoma, the pathophysiology remains poorly understood and treatment continues to pose a significant challenge.
Subject(s)
Neoplasms, Multiple Primary/therapy , Sweat Gland Neoplasms/therapy , Syringoma/therapy , Humans , Neoplasms, Multiple Primary/diagnosis , Neoplasms, Multiple Primary/etiology , Sweat Gland Neoplasms/diagnosis , Sweat Gland Neoplasms/etiology , Syringoma/diagnosis , Syringoma/etiologySubject(s)
Ectodermal Dysplasia/diagnosis , Fibroadenoma/diagnosis , Sweat Gland Neoplasms/diagnosis , Syringoma/diagnosis , Aged, 80 and over , Ectodermal Dysplasia/complications , Fibroadenoma/etiology , Fibroadenoma/pathology , Follow-Up Studies , Foot/pathology , Humans , Male , Sweat Gland Neoplasms/etiology , Sweat Gland Neoplasms/pathology , Syringoma/etiology , Syringoma/pathologySubject(s)
Antineoplastic Combined Chemotherapy Protocols/adverse effects , Peripheral Blood Stem Cell Transplantation/adverse effects , Poroma/etiology , Sweat Gland Neoplasms/etiology , Female , Humans , Leukemia, Myeloid, Acute/complications , Leukemia, Myeloid, Acute/therapy , Middle Aged , Poroma/pathology , Sweat Gland Neoplasms/pathology , Transplantation, AutologousSubject(s)
Humans , Male , Female , Acrospiroma/epidemiology , Sweat Gland Neoplasms/epidemiology , Sweat Gland Neoplasms/etiology , Sweat Glands/pathology , Sweat Glands , Diagnosis, Differential , Laser Therapy/instrumentation , Laser Therapy/methods , Laser Therapy , Radiography, Thoracic/methods , Radiography, Thoracic/trendsSubject(s)
Adenocarcinoma/radiotherapy , Eye Neoplasms/radiotherapy , Lacrimal Apparatus Diseases/radiotherapy , Neoplasms, Radiation-Induced/etiology , Poroma/etiology , Sweat Gland Neoplasms/etiology , Adenocarcinoma/surgery , Aged , Biopsy , Eye Neoplasms/surgery , Female , Humans , Lacrimal Apparatus Diseases/surgery , Poroma/pathology , Radiotherapy, Adjuvant/adverse effects , Risk Factors , Sweat Gland Neoplasms/pathologyABSTRACT
A poroma is a benign epithelial neoplasm that most commonly presents as a solitary papule on the palm or sole. We report the case of a 25-year-old male, with a history of acute myelogenous leukemia, who developed multiple poromas on the feet. Poromatosis - the occurrence of multiple poromas - has been described in six adults and one child; it appears to be more prevalent in patients with a history of lymphoproliferative disorder or radiation exposure.
Subject(s)
Foot Diseases/diagnosis , Neoplasms, Multiple Primary/diagnosis , Neoplasms, Second Primary/diagnosis , Poroma/diagnosis , Sweat Gland Neoplasms/diagnosis , Adult , Bone Marrow Transplantation/adverse effects , Foot Diseases/etiology , Foot Diseases/pathology , Humans , Leukemia, Myeloid, Acute/complications , Male , Neoplasms, Multiple Primary/etiology , Neoplasms, Multiple Primary/pathology , Neoplasms, Second Primary/etiology , Neoplasms, Second Primary/pathology , Poroma/etiology , Poroma/pathology , Sweat Gland Neoplasms/etiology , Sweat Gland Neoplasms/pathologyABSTRACT
The poroid family of neoplasms includes hidroacanthoma simplex, eccrine poroma, dermal duct tumor, and poroid hidradenoma. These benign adnexal neoplasms are derived from the eccrine or apocrine sweat ducts or glands. Poroid neoplasms, including poromas, have been reported during pregnancy and have been hypothesized to be hormonally influenced. Poromatosis, the occurrence of multiple poromas, rarely has been reported in association with hidrotic ectodermal dysplasia, prior radiation therapy, and non-Hodgkin lymphoma occurring after chemotherapy. We report a case of eruptive poromatosis in pregnancy with 8 poromas occurring in the third trimester, further supporting the hypothesis of a hormonal association in the etiology of this neoplasm.
Subject(s)
Poroma/pathology , Sweat Gland Neoplasms/pathology , Adult , Female , Humans , Poroma/diagnosis , Poroma/etiology , Pregnancy , Pregnancy Trimester, Third , Sweat Gland Neoplasms/diagnosis , Sweat Gland Neoplasms/etiologyABSTRACT
Eccrine porocarcinoma is a potentially fatal form of sweat gland carcinoma, due to its propensity to metastasize through lymph vessels. The authors report the case of a 69-year-old female who presented with swelling of the right leg and an ulcerated lesion of the right great toe. The initial histologic diagnosis was invasive squamous cell carcinoma. On follow-up, the patient developed lymphangitic tumor spread in the right leg, associated with right inguinal lymphadenopathy and lesions in vulva and flank. Reevaluation of the toe lesion led to a revised diagnosis of eccrine porocarcinoma. The patient also had 2 basal cell carcinomas of the multicentric/superficial type in the skin overlying the left breast. Past history included chronic ingestion of liquore arsenic (Fowler's solution) in early adulthood as treatment for dermatitis herpetiformis.