1.
Chemotherapy
; 24(2): 61-7, 1978.
Article
in English
| MEDLINE
| ID: mdl-620611
ABSTRACT
Tri-minocycline prepared by mere dissolution of minocycline in an aqueous solution of a recommended complexing agent or using a preconstituted ready-for-use injection of the complex was administered intravenously to rabbits. Serum values were lower, tissue values higher than after injection of other tri-tetracyclines. Basing on these experimental quantitative data, single doses of tri-minocycline equivalent to 50-150 mg minocycline hydrochloride were administered once or twice daily to 13 adult patients during 1-6 days intravenously, without any serious or unusual side-effects. On average, 12% of the injected antibiotic was excreted in the urine, not later than 96 h after the last dose.
Subject(s)
Minocycline/analogs & derivatives , Tetracyclines/analogs & derivatives , Animals , Half-Life , Humans , Injections, Intravenous , Minocycline/administration & dosage , Minocycline/metabolism , Rabbits , Tissue Distribution
2.
Voen Med Zh
; (9): 20-3, 1975 Sep.
Article
in Russian
| MEDLINE
| ID: mdl-127416
3.
Antibiotiki
; 19(4): 363-8, 1974 Apr.
Article
in Russian
| MEDLINE
| ID: mdl-4282567