ABSTRACT
Active immunization against cholecystokinin fragments 31-33 (CCK-3) and 30-33 (CCK-4) results in long-lasting changes of albino rats' behavior. CCK-3 and CCK-4 covalently linked to antigen-carrier evokes the suppression of the anxiety, decreases some signs of depression-like behavior and changes the level of bioamines and their catabolites in striatum at least for two months after immunization. These data can provide a perspective approach to the problem of long term correction of behavior.
Subject(s)
Anxiety/immunology , Biogenic Amines/metabolism , Brain/metabolism , Cholecystokinin/immunology , Oligopeptides/immunology , Tetragastrin/immunology , Animals , Corpus Striatum/immunology , Corpus Striatum/metabolism , Immunization , Male , Rats , Rats, Wistar , Restraint, Physical , Stress, Psychological/immunology , SwimmingABSTRACT
The inhibitor of monoaminooxydase isatin and the ligand of B-receptors cholecystokinin-4 play a significant role in the suppression and induction of depressive and anxiety states. We induced the formation of auto-antibodies to these compounds against their conjugates with antigen-carrier by immunization of white rats. The result was long-term (more than 2 months) stimulation of depressive and anxiety behavior after immunization to isatin and, in contrast, the suppression of such behavior after immunization to cholecystokinin. The perspective of immunochemical approach to long-term correction of behavior is discussed.
Subject(s)
Anxiety/immunology , Autoantibodies/blood , Depression/immunology , Isatin/immunology , Tetragastrin/immunology , Vaccination , Animals , Anxiety/therapy , Depression/therapy , Immunoconjugates/immunology , Male , Rats , Rats, WistarABSTRACT
The inhibitor of monoaminooxydase isatin and the ligand of B-receptors cholecystokinin-4 play a significant role in the suppression and induction of depressive and anxiety states.We induced the formation of auto-antibodies to these compounds against their conjugates with antigen-carrier by immunization of white rats. The result was long-term (more than2 months) stimulation of depressive and anxiety behaviour after immunization to isatin and, in contrast, the suppression of such behaviour after immunization to cholecystokinin. The perspective of immunochemical approach to long-term correction of behaviour is discussed (AU)
El inhibidor de la monoaminooxidasa isatin y el ligando de B-receptores colecistokinina-4 juegan un papel significativo en la supresión e inducción de los estados de ansiedad y depresión. Nosotros hemos inducido la formación de auto-anticuerpos contra estas sustancias mediante la inmunización de ratas blancas. El resultado fue la estimulación prolongada (más de 2 meses) de conducta depresiva y de ansiedad tras la inmunización con isatin y, por el contrario, la supresión de esta conducta después de la inmunización con colecistokinina. En el artículo se discute la posibilidad de la corrección de la conducta a largo plazo mediante la manipulación immunoquímica (AU)
Subject(s)
Animals , Male , Rats , Mice , Anxiety/immunology , Autoantibodies/blood , Depression/immunology , Isatin/immunology , Tetragastrin/immunology , Vaccination , Anxiety/therapy , Depression/therapy , Immunoconjugates/immunology , Rats, WistarABSTRACT
Active immunization of white rats with cholecystokinin-4 covalently linked to the antigen carrier BSA evoked long-lasting changes in the rats' behavior, which were in the opposite direction to the anxiogenic effects of cholecystokinin-4 itself, showing that immunization had anxiolytic effects. Immunoenzyme analysis demonstrated the presence of antibodies to cholecystokinin-4 in the serum of immunized rats. These data are interesting from the point of view of correcting pathological anxiety and fear states by inverse immunoregulation.
Subject(s)
Anxiety/immunology , Behavior, Animal/physiology , Tetragastrin/immunology , Alcohol Drinking/immunology , Animals , Anxiety/physiopathology , Conditioning, Operant/drug effects , Depression/psychology , Exploratory Behavior/physiology , Fear/physiology , Immunoenzyme Techniques , Male , Motor Activity/physiology , Pain Measurement/drug effects , Peptide Fragments/immunology , Rats , Rats, Wistar , Swimming/psychologyABSTRACT
Active immunisation of albino rats by the BSA-conjugated CCK-4 induced formation of antibodies to the CCK-4 and some long-term changes of the rat behaviour. These changes were contrary to anxiogenic effect of the CCK-4 and demonstrated an anxiolytic effect of the immunisation. The data obtained suggest a possibility of an immunocorrection of pathological anxiety and fear by an inverse immunoregulation.
