Prolonged nitroprusside and intermittent hemodialysis as therapy for intractable hypertension.

Nitroprusside was used with intermittent hemodialysis over a 26-day period in a 6-year-old boy with intractable hypertension. Hemodialysis effectively removed thiocyanate from the blood, thus preventing its accumulation and subsequent toxic manifestations. Prolonged nitroprusside infusion maintained arterial blood pressure at acceptable levels until the patient became responsive to other antihypertensive therapy.

Desulfuration of l-cysteine through transamination and transsulfuration in rat liver.

Desulfuration of L-cysteine by rat liver via a pathway of transamination followed by transsulfuration was studied using cyanide as a sulfur acceptor. More than a 5-fold increase in formation of thiocyanate from L-cysteine and cyanide was observed in the presence of 2-oxoglutarate and pyruvate. L-Cysteine aminotransferase and 3-mercaptopyruvate sulfurtransferase activities in the same preparations were also determined. It was concluded that L-cysteine was desulfurated through transamination and transsulfuration of the resulting 3-mercaptopyruvate, and that the rate-limiting step appears to be the transamination reaction.

[Antimicrobial action of potential isothiocyanate forming substances 7th communication (author's transl)]. / Die antimikrobielle Wirkung von potentiellen Isothiocyanat-Bildnern

A number of (N-aryl-dithiocarbamino)-alkanecarbonic acids bearing halogen substituents and related compounds are described which may be considered potential isothicyanate forming substances. The in vitro fungistatic activity of these compounds was investigated and the results obtained compared with those of captan and thiram. It was demonstrated that the halogen substituted (N-aryl)-dithiocarbamino)-alkanecarbonic acids exert an intensive fungistatic effect with a wide spectrum of activity and that the most active of them are equal to captan and thiram.