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1.
BMC Musculoskelet Disord ; 25(1): 431, 2024 Jun 03.
Article in English | MEDLINE | ID: mdl-38831305

ABSTRACT

BACKGROUND: This study aimed to assess the outcomes of conservative management in patients with thoracolumbar fractures classified with a Thoracolumbar Injury Classification and Severity (TLICS) score of 4 or 5, and to analyze initial imaging findings and clinical risk factors associated with treatment failure. METHODS: In this retrospective analysis, patients with thoracolumbar fractures and a TLICS score of 4 or 5, determined through MRI from January 2017 to December 2020, were included. Patients undergoing conservative treatment were categorized into two groups: Group 1 (treatment success) and Group 2 (treatment failure), based on initial and 6-month follow-up outcomes. Clinical data were compared between the two groups. Initial radiological assessments included three kyphosis measurements (Cobb angle, Gardner angle, and sagittal index [SI]), anterior and posterior wall height, and central canal compromise (CC). Additionally, risk factors contributing to treatment failure were analyzed. RESULTS: The conservative treatment group comprised 84 patients (mean age, 60.25 ± 15.53; range 22-85; 42 men), with 57 in Group 1 and 27 in Group 2. Group 2 exhibited a higher proportion of women, older age, and lower bone mass density (p = 0.001-0.005). Initial imaging findings in Group 2 revealed significantly greater values for Cobb angle, SI, and CC (p = 0.001-0.045 or < 0.001; with cutoff values of 18.2, 12.8, and 7.8%, respectively), and lower anterior wall height (p = 0.001), demonstrating good to excellent interobserver agreement (0.72-0.99, p < 0.001). Furthermore, osteoporosis was identified as a significant risk factor (odds ratio = 5.64, p = 0.008). CONCLUSION: Among patients with TLICS scores of 4 or 5, those experiencing conservative treatment failure exhibited unfavorable initial radiological findings, a higher proportion of women, advanced age, and osteoporosis. Additionally, osteoporosis emerged as a significant risk factor for treatment failure.


Subject(s)
Conservative Treatment , Lumbar Vertebrae , Spinal Fractures , Thoracic Vertebrae , Treatment Failure , Humans , Male , Female , Middle Aged , Retrospective Studies , Thoracic Vertebrae/diagnostic imaging , Thoracic Vertebrae/injuries , Lumbar Vertebrae/diagnostic imaging , Lumbar Vertebrae/injuries , Adult , Aged , Spinal Fractures/diagnostic imaging , Spinal Fractures/therapy , Risk Factors , Aged, 80 and over , Young Adult , Magnetic Resonance Imaging
2.
Ugeskr Laeger ; 186(17)2024 Apr 22.
Article in Danish | MEDLINE | ID: mdl-38704711

ABSTRACT

Non-traumatic fractures due to seizures are an overlooked diagnostic group. It is well known that patients with generalized tonic-clonic seizures have an increased trauma risk. However, the cause of fracture is rarely due to the violent forces of muscle contractions. Usually, the primary patient examination focuses on the aetiology of the seizure, which sometimes delays the diagnosis of fractures. This is a case report of a 19-year-old woman who sustained three compression fractures of the thoracic spine due to a generalized tonic-clonic seizure, and a discussion of the diagnostic challenges in such a rare case.


Subject(s)
Fractures, Compression , Spinal Fractures , Thoracic Vertebrae , Humans , Female , Spinal Fractures/diagnostic imaging , Spinal Fractures/complications , Spinal Fractures/diagnosis , Young Adult , Fractures, Compression/diagnostic imaging , Fractures, Compression/etiology , Fractures, Compression/diagnosis , Fractures, Compression/complications , Thoracic Vertebrae/injuries , Thoracic Vertebrae/diagnostic imaging , Seizures/etiology , Seizures/diagnosis , Fractures, Multiple/diagnostic imaging , Tomography, X-Ray Computed , Epilepsy, Tonic-Clonic/etiology , Epilepsy, Tonic-Clonic/diagnosis
3.
J Orthop Surg Res ; 19(1): 293, 2024 May 12.
Article in English | MEDLINE | ID: mdl-38735944

ABSTRACT

OBJECTIVE: To investigate the effects of bracing on apical vertebral derotation and explore the factors that influence in-brace derotation effects in adolescent idiopathic scoliosis (AIS) patients. For patients with AIS, vertebral rotation causes cosmetic appearance abnormalities and acts as an indicator for curve progression. However, there have been few studies investigating the precise derotation effects of bracing for apical vertebra. The application of EOS imaging system enables quantitative evaluation of vertebral rotation in the axial plane in a standing position. METHODS: There were 82 eligible patients enrolled in current study, who underwent EOS imaging evaluation before and immediately after bracing. The clinical demographic data (age, gender, Risser sign and menstrual status) were recorded. The correlation analyses between derotation effects and key parameters (age, pre-brace Cobb angle, thoracic kyphosis, lumbar lordosis, vertebral rotation, pelvis axial rotation and apical vertebral level) were performed. The in-brace derotation effects stratified by gender, Risser sign, apical vertebral level, menarche status, coronal balance and sagittal balance were also analyzed. RESULTS: The rotation of apical vertebra was decreased from 8.8 ± 6.0 degrees before bracing to 3.8 ± 3.3 degrees immediately after bracing (p < 0.001), and the derotation rate was 49.2 ± 38.3%. The derotation degrees in brace was significantly correlated with major curve Cobb angle (r = 0.240, p = 0.030), minor curve Cobb angle (r = 0.256, p = 0.020) and total curve Cobb angle (r = 0.266, p = 0.016). Both the pre-brace apical vertebral rotation and apical vertebral level were significantly correlated with derotation effects in brace (p < 0.001). Patients with thoracic major curve showed worse derotation effects than those with lumbar major curve (p < 0.001). In addition, patients with coronal balance showed better in-brace derotation effects than those with coronal decompensation (p = 0.005). CONCLUSIONS: A satisfactory apical vertebral derotation rate (approximately 50%) could be obtained immediately after bracing in AIS patients. Pre-brace Cobb angle of curve, pre-brace apical vertebral rotation, apical vertebral level and coronal balance exhibited close associations with in-brace derotation effects of apical vertebra.


Subject(s)
Braces , Scoliosis , Humans , Scoliosis/diagnostic imaging , Scoliosis/therapy , Female , Adolescent , Male , Child , Rotation , Thoracic Vertebrae/diagnostic imaging , Lumbar Vertebrae/diagnostic imaging
4.
J Orthop Surg Res ; 19(1): 296, 2024 May 15.
Article in English | MEDLINE | ID: mdl-38750513

ABSTRACT

BACKGROUND: Osteoporosis is one of the risk factors for screw loosening after lumbar fusion. However, the probability of preoperative osteoporosis screening in patients with lumbar degenerative disease is low. Therefore, the aim of this study was to investigate whether a simplified vertebral bone quality (VBQ) score based on T12 T1-MRI could opportunistically predict osteoporosis in patients with degenerative lumbar spine diseases. METHODS: We retrospectively analyzed cases treated for lumbar degenerative diseases at a single institution between August 2021 and June 2022. The patients were divided into three groups by the lowest T-score: osteoporosis group, osteopenia group, and normal bone mineral density (BMD) group. The signal intensity based on the T12 vertebral body divided by the signal intensity of the cerebrospinal fluid was calculated to obtain the simplified VBQ score, as well as the CT-based T12HU value and the traditional L1-4VBQ score. Various statistical analyses were used to compare VBQ, HU and DEXA, and the optimal T12VBQ threshold for predicting osteoporosis was obtained by plotting the receiver operating curve (ROC) analysis. RESULTS: Total of 166 patients were included in this study. There was a statistically significant difference in T12VBQ scores between the three groups (p < 0.001). Pearson correlation showed that there was a moderate correlation between T12VBQ and T-score (r=-0.406, p < 0.001). The AUC value of T12VBQ, which distinguishes between normal and low BMD, was 0.756, and the optimal diagnostic threshold was 2.94. The AUC value of T12VBQ, which distinguishes osteoporosis from non-osteoporosis, was 0.634, and the optimal diagnostic threshold was 3.18. CONCLUSION: T12VBQ can be used as an effective opportunistic screening method for osteoporosis in patients with lumbar degenerative diseases. It can be used as a supplement to the evaluation of DEXA and preoperative evaluation. TRIAL REGISTRATION: retrospectively registered number:1502-009-644; retrospectively registered number date:27 oct 2022.


Subject(s)
Bone Density , Lumbar Vertebrae , Osteoporosis , Humans , Osteoporosis/diagnostic imaging , Female , Male , Lumbar Vertebrae/diagnostic imaging , Retrospective Studies , Middle Aged , Aged , Magnetic Resonance Imaging/methods , Predictive Value of Tests , Thoracic Vertebrae/diagnostic imaging , Intervertebral Disc Degeneration/diagnostic imaging , Absorptiometry, Photon , Bone Diseases, Metabolic/diagnostic imaging , Bone Diseases, Metabolic/etiology , Adult
5.
BMJ Case Rep ; 17(5)2024 May 22.
Article in English | MEDLINE | ID: mdl-38782443

ABSTRACT

Hodgkin's lymphoma revealed by a medullary compression with a double primary vertebral localisation is extremely rare. We report the case of a boy in middle childhood who was presented with slow progression of medullary compression syndrome over 9 months, ultimately leading to paraplegia with loss of sphincter tone. The spinal MRI showed two tumour processes at T9 and L1 with epidural extension. An anatomical-pathological examination of the biopsy of the tumour mass, along with immunohistochemical analysis, confirmed the diagnosis of a lymphocyte-rich classic Hodgkin's lymphoma, stage IV according to the Ann Arbor classification. The therapeutic strategy was based on chemotherapy. This study aims to report a unique clinical presentation of Hodgkin's lymphoma in a paediatric patient and underscores the diagnostic challenges encountered in such an uncommon scenario.


Subject(s)
Hodgkin Disease , Magnetic Resonance Imaging , Spinal Cord Compression , Humans , Hodgkin Disease/complications , Hodgkin Disease/diagnosis , Spinal Cord Compression/etiology , Spinal Cord Compression/diagnostic imaging , Male , Spinal Cord Neoplasms/diagnostic imaging , Spinal Cord Neoplasms/diagnosis , Spinal Cord Neoplasms/complications , Thoracic Vertebrae/diagnostic imaging , Lumbar Vertebrae , Paraplegia/etiology
6.
BMC Musculoskelet Disord ; 25(1): 403, 2024 May 22.
Article in English | MEDLINE | ID: mdl-38778324

ABSTRACT

BACKGROUND: Physiological thoracic kyphosis (TK) allows sagittal balance of human body. Unlike lumbar lordosis (LL), TK has been relatively neglected in the literature. EOS is an imaging technique employing high-sensitivity xenon particles, featured by low-dose exposure combined with high accuracy compared to conventional radiography. The aim of this study was to investigate predictors of TK in patients with phyiological spine morphology using EOS imaging. METHODS: EOS images of 455 patients without spinal anomalies were retrospectively assessed for TK (T1- T12), upper thoracic kyphosis (UTK, T1-T5), lower thoracic kyphosis (LTK, T5-T12), LL (L1-S1) and pelvic incidence (PI). The latter curves were measured by two researchers separately and the average of the two measurements was used for further analysis. Spearman non-parametric correlation was estimated for age, PI, LL, LTK, UTK and TK. Multiple robust linear regression analysis was employed to estimate TK, controlling for the effect of age, sex, LL and LTK. RESULTS: The mean age of patients was 28.3 ± 19.2 years and 302 (66.4%) of them were females. The mean TK, UTK and LTK was 45.5° ± 9.3, 16 ± 7.4° and 29.7° ± 8.9, respectively. The mean UTK in people under 40 years of age was 17.0° ± 7.2, whereas for patients 40+ years old it was 13.6° ± 7.4. At univariable analysis TK positively correlated with UTK (p<0.001), LTK (p<0.001) an LL (p<0.001). At multivariable linear regression TK increased with LTK (RC = 0.67; 95%CI: 0.59; 0.75) or LL (RC = 0.12; 95%CI: 0.06; 0.18), whereas it decreased with age (RC = -0.06; 95%CI: -0.09;-0.02). CONCLUSION: If EOS technology is available, the above linear regression model could be used to estimate TK based upon information on age, sex, LL and LTK. Alternatively, TK could be estimated by adding to LTK 17.0° ± 7.4 for patients < 40 years of age, or 13.6° ± 7.4 in patients 40 + years old. The evidence from the present study may be used as reference for research purposes and clinical practice, including spine examination of particular occupational categories or athletes.


Subject(s)
Kyphosis , Thoracic Vertebrae , Humans , Kyphosis/diagnostic imaging , Female , Male , Thoracic Vertebrae/diagnostic imaging , Adult , Middle Aged , Retrospective Studies , Young Adult , Adolescent , Aged , Child , Radiography
7.
Spinal Cord Ser Cases ; 10(1): 36, 2024 May 23.
Article in English | MEDLINE | ID: mdl-38782913

ABSTRACT

INTRODUCTION: Spinal intradural arachnoid cysts (SIACs) are rare spinal entities that are categorized as primary or secondary pathologies. Secondary cysts can arise from various traumatic or inflammatory causes including subarachnoid hemorrhage, intrathecal injection or surgery, and infectious meningitis/arachnoiditis. Only a few cases of SIAC secondary to tuberculous meningitis have been previously reported, without details of the surgical treatment. CASE PRESENTATION: A 27-year-old woman diagnosed with tuberculous meningitis developed myelopathy caused by thoracic ventral SIAC and intradural abscess. The patient underwent abscess evacuation and cyst fenestration; however, cyst recurrence occurred. The 2nd surgery consisted of cyst resection via a posterolateral approach with expansive duraplasty and spinal arthrodesis. Re-recurrence occurred, and at the 3rd surgery, cyst-subarachnoid bypass was performed. One year after the 3rd surgery, the myelopathic symptoms recovered, and MR images demonstrated a decreased cyst size. DISCUSSION: Here, we report a rare case of recurrent thoracic SIAC secondary to tuberculous meningitis and arachnoiditis. Simple fenestration is associated with a high risk of recurrence in this pathology. Ventrally located thoracic cysts can be approached with posterolateral approach with pedicles resected followed by instrumented arthrodesis. Even in cases involving gross total resection of the cyst wall, there is a risk of recurrence. In such cases, cyst-subarachnoid bypass with a large-diameter tube can be effective.


Subject(s)
Arachnoid Cysts , Spinal Cord Diseases , Thoracic Vertebrae , Tuberculosis, Meningeal , Humans , Female , Adult , Arachnoid Cysts/surgery , Arachnoid Cysts/complications , Arachnoid Cysts/diagnostic imaging , Tuberculosis, Meningeal/complications , Tuberculosis, Meningeal/surgery , Spinal Cord Diseases/surgery , Spinal Cord Diseases/diagnostic imaging , Thoracic Vertebrae/surgery , Thoracic Vertebrae/diagnostic imaging , Recurrence
8.
Physiother Res Int ; 29(3): e2100, 2024 Jul.
Article in English | MEDLINE | ID: mdl-38821882

ABSTRACT

BACKGROUND: Age-related thoracic kyphosis can impair posture, diaphragmatic excursion, respiratory function, and overall quality of life (QoL). PURPOSE: This randomized controlled trial aimed to compare the effects of corrective exercises alone versus combined with diaphragmatic breathing exercises on thoracic kyphosis, diaphragmatic excursion, thoracic pain, and QoL in postmenopausal kyphotic women. METHODS: Forty postmenopausal women diagnosed with thoracic kyphosis were randomly divided into two groups. Group A received corrective exercises for 12 weeks (n = 20), while Group B received both diaphragmatic breathing exercises and corrective exercises for the same duration (n = 20). Primary outcome measures were thoracic kyphosis angle and diaphragmatic excursion, while secondary outcome measures were thoracic pain and QoL. Both groups were assessed pre- and post-intervention using a flexible curve ruler for the thoracic kyphosis angle, ultrasonography for the diaphragmatic excursion, the visual analog scale for thoracic pain, and the Arabic version of the QoL Questionnaire of the European Foundation for Osteoporosis for QoL. RESULTS: Both groups showed significant within-group improvements in all measures post-intervention (p < 0.05). Between-group comparisons post-intervention revealed no significant differences (p > 0.05) except for diaphragmatic excursion, where Group B showed significantly greater improvement (p < 0.05). CONCLUSIONS: A 12-week program of corrective exercises alone or combined with diaphragmatic breathing exercises significantly improved kyphosis angle, thoracic pain, and QoL in postmenopausal kyphotic women. The addition of diaphragmatic breathing exercises provided further benefits by increasing diaphragmatic excursion to a greater degree compared with corrective exercises alone.


Subject(s)
Breathing Exercises , Diaphragm , Kyphosis , Postmenopause , Quality of Life , Humans , Female , Kyphosis/rehabilitation , Kyphosis/diagnostic imaging , Middle Aged , Postmenopause/physiology , Diaphragm/diagnostic imaging , Diaphragm/physiopathology , Aged , Exercise Therapy/methods , Thoracic Vertebrae/diagnostic imaging , Treatment Outcome
9.
BMC Pediatr ; 24(1): 372, 2024 May 30.
Article in English | MEDLINE | ID: mdl-38811872

ABSTRACT

BACKGROUND: To evaluate the effects of local radiotherapy (RT) on growth, we evaluated the chronological growth profiles and vertebral features of children with high-risk neuroblastoma. METHODS: Thirty-eight children who received local photon or proton beam therapy to the abdomen or retroperitoneum between January 2014 and September 2019 were included. Simple radiography of the thoracolumbar spine was performed before and every year after RT. The height and vertical length of the irradiated vertebral bodies (VBs) compared with the unirradiated VBs (vertebral body ratio, VBR) were analyzed using the linear mixed model. Shape feature analysis was performed to compare the irradiated and unirradiated vertebrae. RESULTS: The follow-up was a median of 53.5 months (range, 21-81 months) after RT. A decline in height z-scores was mainly found in the early phase after treatment. In the linear mixed model with height, the initial height (fixed, p < 0.001), sex (time interaction, p = 0.008), endocrine dysfunction (time interaction, 0.019), and age at diagnosis (fixed and time interaction, both p = 0.002) were significant. Unlike the trend in height, the change in VBR (ΔVBR) decreased gradually (p < 0.001). The ΔVBR in the group that received more than 30 Gy decreased more than in the group that received smaller doses. In the shape feature analysis, the irradiated VBs changed to a more irregular surface that were neither round nor rectangular. CONCLUSION: The irradiated VBs in children were gradually restricted compared to the unirradiated VBs in long-term follow-up, and higher RT doses were significantly affected. Radiation-induced irregular features of VBs were observed.


Subject(s)
Neuroblastoma , Humans , Neuroblastoma/radiotherapy , Neuroblastoma/diagnostic imaging , Male , Female , Child, Preschool , Child , Infant , Follow-Up Studies , Retrospective Studies , Body Height/radiation effects , Thoracic Vertebrae/radiation effects , Thoracic Vertebrae/diagnostic imaging , Lumbar Vertebrae/radiation effects , Lumbar Vertebrae/diagnostic imaging , Abdominal Neoplasms/radiotherapy , Abdominal Neoplasms/diagnostic imaging , Vertebral Body/diagnostic imaging , Vertebral Body/radiation effects , Proton Therapy/adverse effects , Retroperitoneal Neoplasms/radiotherapy , Retroperitoneal Neoplasms/diagnostic imaging
10.
BMC Med Imaging ; 24(1): 109, 2024 May 14.
Article in English | MEDLINE | ID: mdl-38745329

ABSTRACT

BACKGROUND: Spinal deformations, except for acute injuries, are among the most frequent reasons for visiting an orthopaedic specialist and musculoskeletal treatment in adults and adolescents. Data on the morphology and anatomical structures of the spine are therefore of interest to orthopaedics, physicians, and medical scientists alike, in the broad field from diagnosis to therapy and in research. METHODS: Along the course of developing supplementary methods that do not require the use of ionizing radiation in the assessment of scoliosis, twenty CT scans from females and males with various severity of spinal deformations and body shape have been analysed with respect to the transverse distances between the vertebral body and the spinous process end tip and the skin, respectively, at thoracic and lumbar vertebral levels. Further, the locations of the vertebral bodies have been analysed in relation to the patient's individual body shape and shown together with those from other patients by normalization to the area encompassed by the transverse body contour. RESULTS: While the transverse distance from the vertebral body to the skin varies between patients, the distances from the vertebral body to the spinous processes end tips tend to be rather similar across different patients of the same gender. Tables list the arithmetic mean distances for all thoracic and lumbar vertebral levels and for different regions upon grouping into mild, medium, and strong spinal deformation and according to the range of spinal deformation. CONCLUSIONS: The distances, the clustering of the locations of the vertebral bodies as a function of the vertebral level, and the trends therein could in the future be used in context with biomechanical modeling of a patient's individual spinal deformation in scoliosis assessment using 3D body scanner images during follow-up examinations.


Subject(s)
Lumbar Vertebrae , Scoliosis , Thoracic Vertebrae , Tomography, X-Ray Computed , Humans , Male , Female , Thoracic Vertebrae/diagnostic imaging , Tomography, X-Ray Computed/methods , Lumbar Vertebrae/diagnostic imaging , Adult , Adolescent , Scoliosis/diagnostic imaging , Middle Aged , Aged , Young Adult
11.
Neuroradiology ; 66(7): 1235-1238, 2024 Jul.
Article in English | MEDLINE | ID: mdl-38755334

ABSTRACT

Neurofibromatosis type 1 (NF1) is a multisystem neurocutaneous disorder. Scoliosis and dural ectasia are features of the associated mesodermal dysplasia. Lateral thoracic meningoceles can develop in NF1 and progressively enlarge due to cerebrospinal fluid (CSF) pulsations. Large meningoceles can cause compressive symptoms in the thorax. We are reporting a case of a NF1 presenting with acute onset respiratory distress, who also had chronic orthostatic headaches. CT chest showed unruptured enlarging bilateral lateral thoracic meningoceles causing lung compression. MRI of the brain and spine showed features of CSF hypotension, explaining the headaches. CSF hypotension with unruptured meningoceles is extremely rare. Management of the condition is challenging since surgical removal is prone to complications due to underlying mesodermal abnormalities. Cystoperitoneal shunting to relieve lung compression may worsen CSF hypotension. A shunt with a programmable valve allowed controlled drainage and successfully relieved lung compression without worsening of orthostatic headaches in our case.


Subject(s)
Meningocele , Neurofibromatosis 1 , Humans , Neurofibromatosis 1/complications , Meningocele/diagnostic imaging , Meningocele/complications , Meningocele/surgery , Magnetic Resonance Imaging , Tomography, X-Ray Computed , Male , Female , Intracranial Hypotension/diagnostic imaging , Intracranial Hypotension/etiology , Hypotension/etiology , Thoracic Vertebrae/diagnostic imaging , Thoracic Vertebrae/surgery , Diagnosis, Differential , Rare Diseases
12.
Tomography ; 10(5): 738-760, 2024 May 13.
Article in English | MEDLINE | ID: mdl-38787017

ABSTRACT

Radiation treatment of cancers like prostate or cervix cancer requires considering nearby bone structures like vertebrae. In this work, we present and validate a novel automated method for the 3D segmentation of individual lumbar and thoracic vertebra in computed tomography (CT) scans. It is based on a single, low-complexity convolutional neural network (CNN) architecture which works well even if little application-specific training data are available. It is based on volume patch-based processing, enabling the handling of arbitrary scan sizes. For each patch, it performs segmentation and an estimation of up to three vertebrae center locations in one step, which enables utilizing an advanced post-processing scheme to achieve high segmentation accuracy, as required for clinical use. Overall, 1763 vertebrae were used for the performance assessment. On 26 CT scans acquired for standard radiation treatment planning, a Dice coefficient of 0.921 ± 0.047 (mean ± standard deviation) and a signed distance error of 0.271 ± 0.748 mm was achieved. On the large-sized publicly available VerSe2020 data set with 129 CT scans depicting lumbar and thoracic vertebrae, the overall Dice coefficient was 0.940 ± 0.065 and the signed distance error was 0.109 ± 0.301 mm. A comparison to other methods that have been validated on VerSe data showed that our approach achieved a better overall segmentation performance.


Subject(s)
Imaging, Three-Dimensional , Lumbar Vertebrae , Neural Networks, Computer , Thoracic Vertebrae , Tomography, X-Ray Computed , Humans , Thoracic Vertebrae/diagnostic imaging , Tomography, X-Ray Computed/methods , Lumbar Vertebrae/diagnostic imaging , Imaging, Three-Dimensional/methods , Female , Male
13.
Pediatr Transplant ; 28(4): e14599, 2024 Jun.
Article in English | MEDLINE | ID: mdl-38713752

ABSTRACT

BACKGROUND: The outcomes after liver transplantation have greatly improved, which has resulted in greater focus on improving non-hepatic outcomes of liver transplantation. The present study aimed to evaluate thoracic spine radio density in children and adolescents after liver transplantation. METHODS: A total of 116 patients who underwent living donor liver transplantation were retrospectively analyzed. The radio density at the eleventh thoracic vertebra was measured using computed tomography scan performed preoperatively then annually for 5 years postoperatively and subsequently every 2 or 3 years. RESULTS: The mean thoracic radio density of male recipients of male grafts had the lowest values during the study. The radio density of patients receiving a graft from a female donor was higher than in recipients with grafts from males. Total mean radio density decreased for first 5 years postoperatively and then increased. Changes in radio density were equally distributed in both steroid withdrawal and no steroid withdrawal groups for 5 years, after which patients with steroid withdrawal had a greater increase. Changes in radio density were equally distributed in both the steroid withdrawal and no steroid withdrawal groups up to age 20, after which patients in the steroid withdrawal group had a greater increase. CONCLUSIONS: Gender differences may affect the outcome of radio density changes after transplantation. Given the moderate association between thoracic radio density and bone mineral density in skeletally mature adults and further studies are needed to validate this relationship between thoracic radio density and bone mineral density changes in pediatric liver transplantation.


Subject(s)
Bone Density , Liver Transplantation , Living Donors , Thoracic Vertebrae , Tomography, X-Ray Computed , Humans , Male , Female , Child , Retrospective Studies , Adolescent , Child, Preschool , Thoracic Vertebrae/surgery , Thoracic Vertebrae/diagnostic imaging , Infant , Young Adult , Treatment Outcome , Sex Factors
14.
BMJ Case Rep ; 17(5)2024 May 27.
Article in English | MEDLINE | ID: mdl-38802257

ABSTRACT

We present a rare case of a male child in middle childhood who presented to the emergency department with neck pain, neck deformity, low-grade fever, breathing difficulty and swallowing difficulty. The patient had a significant history of weight loss and loss of appetite. On examination, neurological deficits were observed, including mildly increased tone in bilateral lower limbs, reduced power in both lower limbs, exaggerated knee and ankle jerks, and upgoing plantar reflexes. Radiographs and MRI revealed a kyphotic deformity with apex at the T1 vertebra, lytic lesions in seven contiguous vertebrae and a large prevertebral abscess extending from C2 to T5. The patient underwent a posterior-only surgical approach with decompression, abscess drainage and stabilisation, resulting in successful cord decompression and correction of the kyphotic deformity. At 18 months follow-up, the patient is doing well with improvement to normal neurology and full return of a child to normal activities.


Subject(s)
Cervical Vertebrae , Tuberculosis, Spinal , Humans , Male , Tuberculosis, Spinal/complications , Tuberculosis, Spinal/surgery , Tuberculosis, Spinal/diagnosis , Tuberculosis, Spinal/diagnostic imaging , Cervical Vertebrae/diagnostic imaging , Magnetic Resonance Imaging , Decompression, Surgical/methods , Child , Kyphosis/surgery , Kyphosis/diagnostic imaging , Thoracic Vertebrae/diagnostic imaging , Thoracic Vertebrae/surgery
15.
Int J Rheum Dis ; 27(4): e15146, 2024 Apr.
Article in English | MEDLINE | ID: mdl-38661342

ABSTRACT

OBJECTIVE: Hounsfield units (HU) measured using computed tomography (CT) have gained considerable attention for the detection of osteoporosis. This study aimed to investigate whether opportunistic CT could predict vertebral fractures in patients with rheumatoid arthritis (RA). METHODS: A total of 233 patients with RA who underwent chest CT were included in this study. The HU values of the anterior 1/3 of the vertebral bodies based on the sagittal plane at T11-L2 after reconstruction were measured. The incidence of vertebral fractures was investigated with respect to the HU value. RESULTS: Vertebral fractures were identified in 32 patients during a mean follow-up period of 3.8 years. In patients who experienced vertebral fractures within 2 years of CT imaging, the HU values of the vertebral bodies (T11-L2) were lower than those in patients who did not experience fractures. Receiver operating characteristic curve analysis identified that a T11 HU value of <125 was a risk factor for vertebral fracture within 2 years. Multivariate analysis showed that a T11 HU value of <125 and the existence of prevalent vertebral fractures were significant risk factors for fracture. CONCLUSION: HU measurements of the anterior 1/3 of the vertebral body are a potential predictor for vertebral fractures in patients with RA.


Subject(s)
Arthritis, Rheumatoid , Osteoporotic Fractures , Predictive Value of Tests , Spinal Fractures , Humans , Arthritis, Rheumatoid/diagnostic imaging , Arthritis, Rheumatoid/complications , Arthritis, Rheumatoid/epidemiology , Spinal Fractures/diagnostic imaging , Spinal Fractures/epidemiology , Spinal Fractures/etiology , Female , Male , Aged , Middle Aged , Risk Factors , Japan/epidemiology , Osteoporotic Fractures/epidemiology , Osteoporotic Fractures/diagnostic imaging , Osteoporotic Fractures/etiology , Time Factors , Incidence , Thoracic Vertebrae/diagnostic imaging , Thoracic Vertebrae/injuries , ROC Curve , Risk Assessment , Tomography, X-Ray Computed , Lumbar Vertebrae/diagnostic imaging , Multivariate Analysis , Retrospective Studies , Prevalence , Aged, 80 and over , Area Under Curve
17.
RMD Open ; 10(2)2024 Apr 27.
Article in English | MEDLINE | ID: mdl-38677879

ABSTRACT

OBJECTIVES: The purpose of our study was to characterise spatiotemporal features of disease progression in people with diffuse idiopathic skeletal hyperostosis (DISH), early-phase DISH, and those not meeting either criterion who had repeated CT scans of the thoracic spine. METHODS: A retrospective study was designed in collaboration with the Rochester Epidemiology Project to evaluate completeness of ectopic bridging across the thoracic spine and corresponding disease status over an average of 2.7 years (range from 0.2 to 15.0 years) in a cohort of 83 female and 74 male individuals. RESULTS: Over 15% of individuals displayed changes in imaging features over time that resulted in a revised diagnosis along the continuum of DISH. Early-phase DISH was marked by new involvement of previously unaffected motion segments, estimated to occur over 2.1 years. Advanced presentations of DISH were marked by increased prevalence of complete bridging (average two of three available motion segments), estimated to occur over 2.6-2.9 years. Localised nodules of ectopic mineralisation external to and within the intervertebral disc were regularly observed in early-phase DISH. CONCLUSIONS: This is the first characterisation of spatiotemporal features across all phases of DISH, indicating that progression of DISH is characterised by distinct features at different phases along the disease continuum. Localised nodules of mineralisation in the spinal ligaments and within the intervertebral discs coincident with early phases of the disease may be a key factor in the pathogenesis of DISH.


Subject(s)
Disease Progression , Hyperostosis, Diffuse Idiopathic Skeletal , Tomography, X-Ray Computed , Humans , Hyperostosis, Diffuse Idiopathic Skeletal/diagnostic imaging , Hyperostosis, Diffuse Idiopathic Skeletal/epidemiology , Male , Female , Aged , Retrospective Studies , Middle Aged , Thoracic Vertebrae/diagnostic imaging , Thoracic Vertebrae/pathology , Aged, 80 and over , Spatio-Temporal Analysis
18.
BMC Musculoskelet Disord ; 25(1): 338, 2024 Apr 26.
Article in English | MEDLINE | ID: mdl-38671421

ABSTRACT

OBJECTIVES: The application of a growing rod technique can retain the growth and development potential of the spine and thorax while controlling the progression of scoliosis deformity. Theoretically, convex side short fusion combined with a concave side single growing rod technique can significantly reduce the asymmetric growth of the spine in the vertex region in most patients. However, the final clinical outcome of various techniques is yet to be clearly determined and compared between studies. Therefore, we compared the efficacy of these two growing rod techniques in treating early onset scoliosis. METHODS: In a retrospective study of 152 EOS patients seen between 2013.1 and 2019.12, 36 cases of EOS patients were selected for inclusion. Among the 36 cases, 11 cases were treated with convex side short fusion combined with a concave side single growing rod technique, group (A) The remaining 25 cases were treated with traditional bilateral growing rod technique, group (B) Age, gender, etiology, follow-up time, Cobb angle of main curve, T1-S1 height, coronal trunk shift, sagittal vertical axis (SVA), Cobb angle of thoracic kyphosis at last follow-up, and Cobb angle at proximal junction kyphosis of the first and last post-operation follow-up were recorded. In addition, internal fixation related complications, infection, nervous system complications were recorded as well. RESULTS: There was no statistically significant difference between group A and group B in preoperative age, Cobb angle of main curve, coronal trunk shift, T1-S1 height, SVA, Cobb angle of thoracic kyphosis (p > 0.05). However, at the last follow-up (Group A, mean 4.4 ± 1.01 years; Group B, mean 3.6 ± 0.01 years) the Cobb angle of the main curve was less and T1-S1 height greater in group A compared with group B (p < 0.05). There was no statistically significant difference between group A and group B in the correction rate of the Cobb angle of the main curve or the growth rate of T1-S1 height (p > 0.05). There was no statistically significant difference in the coronal imbalance ratio, thoracic kyphosis abnormality ratio, or the occurrence PJK ratio between group A and group B at the last follow-up (p > 0.05), but the sagittal imbalance ratio and internal fixation abnormality ratio were higher in group A than in the group B (p < 0.05). CONCLUSIONS: During the treatment of EOS, both the convex side short fusion combined with concave side single growing rod technique and traditional bilateral growing rod technique can correct the Cobb angle of main curve with no significant hindering of the spinal growth observed. The traditional bilateral growing rod technique has advantages in control of the sagittal balance of the spine, and the complications associated with internal fixation were lower.


Subject(s)
Scoliosis , Spinal Fusion , Humans , Scoliosis/surgery , Scoliosis/diagnostic imaging , Female , Retrospective Studies , Male , Spinal Fusion/methods , Spinal Fusion/adverse effects , Spinal Fusion/instrumentation , Child , Treatment Outcome , Thoracic Vertebrae/surgery , Thoracic Vertebrae/diagnostic imaging , Child, Preschool , Follow-Up Studies , Age of Onset
19.
BMJ Case Rep ; 17(4)2024 Apr 29.
Article in English | MEDLINE | ID: mdl-38684351

ABSTRACT

Aneurysmal bone cysts (ABCs) are primary bone tumours that rarely occur in the spine and generally affect one vertebral level in adolescents. Here, we present an unusual case of a multilevel thoracolumbar ABC, which presented a unique surgical challenge due to its infiltrative and destructive nature. A teenage male presented with back pain, paresthesias and a mildly spastic gait. MRI of the thoracolumbar spine revealed an expansive, multicystic mass extending from the left T12-L1 vertebral bodies into adjacent musculature. The patient underwent a two-stage surgical approach with decompression of the spinal cord and instrumentation to stabilise the vertebral column. The first stage involved posterior decompression, laminectomy and facetectomies, followed by pedicle-based instrumentation from T10 to L3. This was followed by a vertebrectomy and anterior stabilisation with an expansile cage from T11 to L2. A gross total resection was achieved with the patient maintaining full neurological function.


Subject(s)
Bone Cysts, Aneurysmal , Decompression, Surgical , Lumbar Vertebrae , Magnetic Resonance Imaging , Thoracic Vertebrae , Humans , Bone Cysts, Aneurysmal/surgery , Bone Cysts, Aneurysmal/diagnostic imaging , Male , Thoracic Vertebrae/surgery , Thoracic Vertebrae/diagnostic imaging , Adolescent , Lumbar Vertebrae/surgery , Decompression, Surgical/methods , Laminectomy/methods , Treatment Outcome , Back Pain/etiology , Back Pain/surgery
20.
Reg Anesth Pain Med ; 49(6): 465-468, 2024 Jun 03.
Article in English | MEDLINE | ID: mdl-38580340

ABSTRACT

INTRODUCTION: This case report documents a postoperative, incomplete sensorimotor paraparesis from thoracic vertebral body 6 (Th6) after combined anesthesia for upper abdominal surgery in a patient who had a thoracic localization of spinal epidural lipomatosis (SEL). CASE PRESENTATION: The patient was treated in our clinic with a thoracic epidural catheter (TEA) for perioperative analgesia during a partial duodenopancreatectomy. Paraparetic symptoms occurred 20 hours after surgery. Initial MRI did not show bleeding, infection or spinal cord damage and the neurosurgeon consultants recommended observation. The neurological examination and the third follow-up MRI on 15th postoperative day showed ventrolateral damage of the spinal cord at level Th6. It is possible that local anesthetic compressed the spinal cord in addition to the existing lipomatosis and the thoracic kyphosis. The paraparesis improved during follow-up paraplegiologic treatment. CONCLUSION: So far, only two uncomplicated lumbar epidural catheter anesthesias have been described in patients who had a lumbar SEL. Epidural catheter anesthesia is a safe and effective method of pain control. But it is important to carefully identify and stratify patients with risk factors during the premedication visit. In patients who had kyphosis and thoracic localization of SEL, TEA may only be used after a risk-benefit assessment.


Subject(s)
Anesthesia, Epidural , Lipomatosis , Thoracic Vertebrae , Humans , Anesthesia, Epidural/adverse effects , Lipomatosis/diagnostic imaging , Thoracic Vertebrae/diagnostic imaging , Thoracic Vertebrae/surgery , Pancreaticoduodenectomy/adverse effects , Male , Paraparesis/etiology , Middle Aged , Magnetic Resonance Imaging , Aged
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