ABSTRACT
Sixteen specimens of cadaveric intertoe folds of patients who had suffered from intertrichinous mycoses of the soles (miners who died in accidents or because of traumas) were examined by histologic and histochemical methods. For control intertoe fold specimens from 10 suddenly dead workers without mycoses were examined. Examinations of skin specimens from mycosis foci have revealed fungus mycelium in the epidermis and superficial layers of the derma, focal perivascular infiltrates consisting mainly of T-lymphocytes (a positive reaction to alpha-naphthylacetate esterase), macrophages, sensitized lymphocytes (high acid phosphatase activity); this necessitates administration, along with mycocidal agents, of angioprotectors, proteolysis inhibitors, immunostimulants. Histoenzymologic studies have revealed impairments of the principal components of metabolism and activation of glycolysis processes. Less manifest changes were revealed in apparently intact skin, this being an evidence of a systemic involvement of the skin in a prolonged mycotic process.
Subject(s)
Skin/pathology , Tinea Pedis/pathology , Biopsy , Dermatitis, Occupational/enzymology , Dermatitis, Occupational/pathology , Foot/pathology , Histocytochemistry , Humans , Mining , Oxidoreductases/metabolism , Skin/enzymology , Tinea Pedis/enzymologyABSTRACT
Nonspecific esterase activities were measured in the peripheral blood phagocytes (neutrophils and monocytes) of 37 patients with mycoses of the soles. The measurements have revealed lowered potentials of alpha-naphthylacetate esterase, naphthol-AS-acetate esterase, and naphthol-AS-D-chloracetate esterase, which appears to be due to depressed leucocyte phagocytic activity. Diucifon therapy corrected this metabolic imbalance.
