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Drug Test Anal ; 11(4): 578-585, 2019 Apr.
Article in English | MEDLINE | ID: mdl-30367738

ABSTRACT

The metabolism of the masking agent tolcapone in the horse has been investigated. This substance was found to have undergone various chemical transformations that produced a large variety of phase I metabolites, as well as glucuronide and sulfate conjugation. Confirmation of the presence of tolcapone and the 3-O-methylated metabolite in the blood samples collected up to 240 minutes and in urine obtained up to 24 hours, was successfully conducted using both gas chromatography- and liquid chromatography-tandem mass spectrometry techniques. The 3-O-methyl tolcapone is the better marker to use in a screening method because, in comparison to tolcapone, we have found that this substance offers superior chromatographic performance that should potentially give a lower limit of detection.


Subject(s)
Catechol O-Methyltransferase Inhibitors/blood , Catechol O-Methyltransferase Inhibitors/urine , Horses/blood , Horses/urine , Tolcapone/blood , Tolcapone/urine , Animals , Catechol O-Methyltransferase Inhibitors/metabolism , Chromatography, High Pressure Liquid , Drug Monitoring , Gas Chromatography-Mass Spectrometry , Horses/metabolism , Methylation , Substance Abuse Detection , Tolcapone/metabolism
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