ABSTRACT
Retention after treatment and effective anchorage control are two essential factors in orthodontics. Our study aimed to explore the effects of fucoidan on orthodontic tooth movement (OTM) and the involvement of macrophages. We established a murine OTM model to test the effect of fucoidan administration. We found that mice injected with fucoidan had a deceleration in OTM and a higher bone mineral density. Moreover, fucoidan increased the proportion of F4/80+ CD206+ macrophages and promoted the messenger RNA expression of Arg-1, CD206, and IL-10 at both in vivo and in vitro levels. In addition, macrophages showed lower expression of TNF-α, IL-1ß, and IL-6 and a decrease in F4/80+ CD11c+ cells. Mechanistically, the level of phosphorylated STAT3 was elevated in unpolarized and restorative macrophages after treatment with fucoidan. Taken together, our findings suggest that fucoidan treatment inhibits OTM and enhances the stability of teeth after movement by promoting restorative macrophages through the STAT3 pathway.
Subject(s)
Macrophages/metabolism , Polysaccharides/pharmacology , STAT3 Transcription Factor/genetics , Tooth Abnormalities/drug therapy , Animals , Bone Density/genetics , Cell Polarity/genetics , Disease Models, Animal , Gene Expression Regulation/drug effects , Humans , Interleukin-10/genetics , Macrophage Activation/drug effects , Macrophages/pathology , Mice , Osteoclasts/drug effects , Tooth Abnormalities/genetics , Tooth Abnormalities/pathology , Tooth Movement Techniques , Tumor Necrosis Factor-alpha/geneticsABSTRACT
BACKGROUND: West Syndrome is a rare epileptic encephalopathy involving infantile spasms, altered electroencephalographic pattern with hypsarrhythmia, and psychomotor development delay. It arises in paediatric patients, generally within the first year of life, in symptomatic or idiopathic form depending on the presence of hereditary features or not. CASE REPORT: In this report it is described the case of a West syndrome patient affected by multiple caries, gingival enlargement, dental eruption abnormalities, high-arched palate and MIH, treated at the dental clinic of University of Bari "Aldo Moro". DISCUSSION: West patients present with multiple oral abnormalities, including altered eruption timing, teeth agenesis, teeth shape and position abnormalities, plaque and calculus accumulation, malocclusions and bad oral habits (mouth breathing, nails biting). CONCLUSION: West Syndrome patients' oral hygiene is generally bad due to their motor difficulty and to their low compliance towards dentists, which entails general anaesthesia to perform dental treatment. West Syndrome pharmacological treatment is usually based on antiepileptic drugs and/or ACTH. These medications are well known for their ability to induce gingival enlargement, increasing the possibility of plaque accumulation and gingivitis development.
Subject(s)
Dental Caries/drug therapy , Epilepsy, Generalized/drug therapy , Tooth Abnormalities/drug therapy , Anticonvulsants/therapeutic use , Child , Dental Caries/diagnosis , Epilepsy, Generalized/diagnosis , Female , Humans , Tooth Abnormalities/diagnosisABSTRACT
The development of the hedgehog pathway inhibitor vismodegib provides a new treatment option for metastasised and locally advanced basal cell carcinoma in which surgical excision or radiotherapy is contraindicated. Only a fraction of patients with basal cell carcinoma are eligible for this therapy, but it is effective in the majority of those who do receive vismodegib. However, development of tumour resistance is quite common and adverse events frequently lead to discontinuation of therapy. Intermittent treatment or combination therapy could reduce the occurrence of tumour resistance and diminish toxicity. We present three patients who were successfully treated with vismodegib: a 73-year-old man with locally advanced basal cell carcinoma, an 82-year-old man with basal cell carcinoma that had metastasised to the lungs, and a 42-year-old man with Gorlin syndrome.
Subject(s)
Anilides/therapeutic use , Antineoplastic Agents/therapeutic use , Carcinoma, Basal Cell/drug therapy , Pyridines/therapeutic use , Skin Neoplasms/drug therapy , Adult , Aged , Craniofacial Abnormalities/drug therapy , Disease Progression , Eye Abnormalities/drug therapy , Foot Deformities, Congenital/drug therapy , Humans , Male , Molecular Targeted Therapy , Syndactyly/drug therapy , Tooth Abnormalities/drug therapy , Treatment OutcomeABSTRACT
Morphological study confirmed the positive effect of succinic acid on tissue ultrastructure, energy metabolism in cells of fibroblastic differon, reorganization and neogenesis of intercellular substance of the periodontal connective tissue during the retention period after correction of simulated dental torsion abnormality in dogs.
