ABSTRACT
We report the clinical course of a woman 31 weeks pregnant who ingested misoprostol (a prostaglandin E1 analog, Cytotek, used to prevent gastric ulcer) and trifluoperazine (Stelazine). Manifestations of toxicity included hypertonic uterine contraction with fetal death, hyperthermia, rhabdomyolysis, hypoxemia, respiratory alkalosis, and metabolic acidosis. We are concerned that misoprostol may be used as an llicit abortifacient.
Subject(s)
Abortion, Criminal , Misoprostol/poisoning , Adult , Drug Overdose , Female , Humans , Pregnancy , Suicide, Attempted , Trifluoperazine/poisoningABSTRACT
A woman developed rigidity, autonomic instability and altered consciousness after taking an overdose of trifluoperazine and carbamazepine. A diagnosis of NMS was made despite the absence of fever, as carbamazepine might modify the presentation of NMS.
Subject(s)
Bipolar Disorder/drug therapy , Carbamazepine/poisoning , Drug Overdose/complications , Neuroleptic Malignant Syndrome/diagnosis , Trifluoperazine/poisoning , Body Temperature/drug effects , Carbamazepine/administration & dosage , Drug Therapy, Combination , Female , Humans , Middle Aged , Trifluoperazine/administration & dosageABSTRACT
A drug-free interval is often recommended when switching monoamine oxidase inhibitors, although the evidence firmly supporting this caution has been minimal. A case is reported where an abrupt change in monoamine oxidase inhibitor was followed by the death of a patient.
Subject(s)
Death, Sudden/etiology , Monoamine Oxidase Inhibitors/poisoning , Female , Humans , Isocarboxazid/poisoning , Maprotiline/poisoning , Middle Aged , Trifluoperazine/poisoningABSTRACT
A fatal case of trifluoperazine poisoning is reported. Case history, pathological findings, and the concentrations of trifluoperazine and its metabolites in blood, liver, and kidney are presented.
Subject(s)
Trifluoperazine/poisoning , Adult , Female , Humans , Trifluoperazine/metabolismSubject(s)
Exploratory Behavior/physiology , Hypothalamus/physiology , Sleep, REM/physiology , Acoustic Stimulation/adverse effects , Alcoholism/physiopathology , Animals , Anxiety/psychology , Brain Mapping , Chlorpromazine/poisoning , Dyskinesia, Drug-Induced/physiopathology , Electric Stimulation , Escape Reaction/physiology , Humans , Rabbits , Rats , Seizures/physiopathology , Self Stimulation/physiology , Sleep Deprivation , Trifluoperazine/poisoningABSTRACT
Psychotropic drugs such as the phenothiazine neuroleptics and tricyclic antidepressants are known to cause electrocardiographic abnormalities as well as a central anticholinergic syndrome. Physostigmine is known to reverse the central muscarinic anticholinergic manifestations by inhibition of the enzyme cholinesterase. An unusual case of trifluoperazine overdose, in which the patient presented with cardiac arrhythmias and a central anticholinergic syndrome, is presented. Treatment with physostigmine reversed the central anticholinergic syndrome as well as the electrocardiographic abnormalities. Effects of phenothiazines on altering cardiac status are also discussed.
Subject(s)
Antipsychotic Agents/poisoning , Arrhythmias, Cardiac/drug therapy , Nervous System Diseases/drug therapy , Physostigmine/therapeutic use , Arrhythmias, Cardiac/chemically induced , Electrocardiography , Humans , Male , Middle Aged , Nervous System Diseases/chemically induced , Parasympatholytics/poisoning , Trifluoperazine/poisoningABSTRACT
Two patients with transient hypercalcaemia during recovery from acute renal failure are described. The literature is reviewed and possible pathophysiological mechanisms discussed. Patients with renal failure following muscle damage should have regular measurement of plasma calcium.
