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J Chromatogr ; 311(1): 109-16, 1984 Nov 09.
Article in English | MEDLINE | ID: mdl-6520151

ABSTRACT

A high-performance liquid chromatographic method for the quantitative determination of benperidol in human plasma using haloperidol as internal standard is described. The method involves liquid-liquid extraction, separation of the substances on a reversed-phase column C18 followed by ultraviolet detection at 254 nm. The mobile phase consists of 32% acetonitrile in 0.05 M potassium dihydrogen phosphate buffer (pH 2.8). The detection limit is 0.5-1.0 ng/ml using 2- or 4-ml plasma samples.


Subject(s)
Benperidol/blood , Chemical Phenomena , Chemistry , Chromatography, High Pressure Liquid/methods , Haloperidol/blood , Humans , Kinetics , Reference Standards , Trifluperidol/blood
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