1.
J Chromatogr
; 148(2): 453-7, 1978 Feb 01.
Article
in English
| MEDLINE
| ID: mdl-621264
ABSTRACT
N,N'-Trimethylene-bis-(pyridinium-4-aldoxime)dibromide, 4-pyridine aldoxime, atropine sulfate, benactyzine hydrochloride, methyl paraben and propyl paraben are separated by ion-pair high-performance liquid chromatography. The method is specific for detecting and quantifying each compound in a complex mixture without solvent extraction or pretreatment. Levels as low as 1 ng on column are quantifiable by the procedure. All components are eluted within 9 min subsequent to the initial injection. Because of the simplicity of the method, the procedure is suitable for routinely monitoring the stability of the various compounds in the formulation during storage.
Subject(s)
Parasympatholytics/analysis , Atropine/analysis , Benactyzine/analysis , Chromatography, High Pressure Liquid , Drug Combinations , Parabens/analysis , Pralidoxime Compounds/analysis , Trimedoxime/analysis
2.
J Pharm Belg
; 33(1): 30-4, 1978.
Article
in French
| MEDLINE
| ID: mdl-351166
3.
Farmatsiia
; 25(5): 77-8, 1976.
Article
in Russian
| MEDLINE
| ID: mdl-1001495