ABSTRACT
Artrites traumáticas, principais causas de claudicação em equinos atletas, cursam com grande impacto econômico, em função da retirada precoce dos animais das atividades atléticas. Inúmeros fatores culminam em lesões articulares, sendo necessário o entendimento do mecanismo fisiopatológico para diagnóstico e tratamento precoce. O presente caso relata uma égua atleta com diagnóstico de osteoartrite causada por excessiva demanda biomecânica na articulação tíbio társica. O tratamento consistiu em consecutivas infiltrações de soro autólogo condicionado IRAP (Interleukin-1 Receptor Antagonist Protein). A resposta foi positiva com evidente melhora do quadro clínico. A terapia, apesar de necessitar mais estudos, já apresenta resultados promissores no tratamento das artropatias em equinos.
Traumatic arthritis, considered to be the main cause of lameness in equine athletes, have a great economic impact due to the early withdrawal of the animals from athletic activities. There are several causes that lead to joint injuries and it is necessary to know the pathophysiological mechanism, to early diagnosis and treatment. The present case reports an athlete mare with osteoarthritis caused by excessive biomechanical demand in the tibio tarsic joint. It was treated with consecutive infiltrations of conditioned autologous serum IRAP (Interleukin-1 Receptor Antagonist Protein). The response was positive with evident improvement of the clinical picture. The therapy, although more studies are needed, already presents promising results in the treatment of equine arthropathies.(au)
Subject(s)
Female , Animals , Tarsal Joints/pathology , Cartilage Diseases/veterinary , Horse Diseases , Osteoarthritis/veterinary , Trochlear Nerve Injuries/veterinaryABSTRACT
Artrites traumáticas, principais causas de claudicação em equinos atletas, cursam com grande impacto econômico, em função da retirada precoce dos animais das atividades atléticas. Inúmeros fatores culminam em lesões articulares, sendo necessário o entendimento do mecanismo fisiopatológico para diagnóstico e tratamento precoce. O presente caso relata uma égua atleta com diagnóstico de osteoartrite causada por excessiva demanda biomecânica na articulação tíbio társica. O tratamento consistiu em consecutivas infiltrações de soro autólogo condicionado IRAP (Interleukin-1 Receptor Antagonist Protein). A resposta foi positiva com evidente melhora do quadro clínico. A terapia, apesar de necessitar mais estudos, já apresenta resultados promissores no tratamento das artropatias em equinos.(AU)
Traumatic arthritis, considered to be the main cause of lameness in equine athletes, have a great economic impact due to the early withdrawal of the animals from athletic activities. There are several causes that lead to joint injuries and it is necessary to know the pathophysiological mechanism, to early diagnosis and treatment. The present case reports an athlete mare with osteoarthritis caused by excessive biomechanical demand in the tibio tarsic joint. It was treated with consecutive infiltrations of conditioned autologous serum IRAP (Interleukin-1 Receptor Antagonist Protein). The response was positive with evident improvement of the clinical picture. The therapy, although more studies are needed, already presents promising results in the treatment of equine arthropathies.(au)
Subject(s)
Animals , Female , Horse Diseases , Cartilage Diseases/veterinary , Tarsal Joints/pathology , Trochlear Nerve Injuries/veterinary , Osteoarthritis/veterinaryABSTRACT
Objetivo: Avaliar a regeneração da cartilagem articular em defeitos osteocondrais do joelho induzidos pelo plasma rico em plaquetas (PRP) autógeno. Métodos: Defeitos osteocondrais produzidos no sulco troclear de ambos os joelhos de dez ovelhas foram preenchidos com PRP autógeno à direita e deixados vazios à esquerda. Avaliação macroscópica e histológica foram efetuadas 12 semanas mais tarde. Os resultados foram avaliados por um escore geral de ambas as avaliações macroscópica e histológica comparativamente entre os lados por meio do teste pareado de Wilcoxon. Resultados: o aspecto macroscópico não foi uniforme entre os animais, nem diferiu entre os joelhos direitos e esquerdos (p=0,03125); em nenhum caso o tecido regenerado se nivelou com a cartilagem normal circundante. Ao exame histológico, cartilagem aparentemente normal não foi detectada em nenhum joelho, mas uma cartilagem pouco diferenciada estava presente em sete joelhos direitos e em três joelhos esquerdos. Tecido fibrocartilaginoso estava presente nos joelhos restantes, com diferença significante no escore geral entre os joelhos direitos e esquerdos (p=0,0313). Conclusão: o PRP como usado neste estudo tem propriedades reparativas da cartilagem articular no joelho de ovelhas, principalmente por estimular a formação de tecido fibrocartilaginoso. Trabalho Experimental.
Objective: To assess the regeneration of osteochondral defects in the joint cartilage of the knee induced by autologous platelet-rich plasma (PRP). methods: osteochondral defects produced in the trochlear groove of both knees of ten sheep; defects of the right knees were filled with autologous PRP and the left knees were left unfilled. macroscopic and microscopic evaluation was carried out 12 week later. the results were evaluated by the total score of both macroscopic and microscopic evaluations comparing the two sides through the wilcoxon paired test. Results: macroscopic appearance was not uniform among animals, nor was it different between the right and left knees (p=0.3125), and in no case the regenerated tissue was equal to the normal surrounding cartilage. At histological examination, apparently normal cartilage was not detected in any knee, but a poorly differentiated cartilage was present in 7 right knees, compared to 3 left knees. Fibrocartilaginous tissue was present in most of the remaining knees, with a significant difference in the overall score between right and left knees (p=0.0313). conclusion: the pRp as used in this study has reparative properties of the joint cartilage of sheep knees, mostly by stimulating the formation of a fibrocartilaginous tissue. Laboratory Investigation.
Subject(s)
Animals , Female , Gels , Histology, Comparative , Knee/physiopathology , Osteochondritis/surgery , Osteochondritis/rehabilitation , Plasma , Sheep , Trochlear Nerve InjuriesABSTRACT
Objetivo: Evaluar las características en el grado de desviación en las lesiones del II y VI nervio, para establecer correlación entre cada una de las situaciones clínicas. Materiales y métodos: Se estudiaron expedientes de pacientes con lesión del III y VI nervio en el Hospital Nuestra Señora de La Luz, desde enero de 2000 hasta enero de 2005. En todos los pacientes se realizó examen oftalmológico completo, donde se evidenciara limitación de -4 ó mayor en III nervio, y limitación de la abducción de -4 ó mayor en VI nervio. Resultados: Se analizaron 71 expedientes, 31 con lesión del III nervio (11 con parálisis, 20 con paresia); 40 con lesión del VI nervio (16 con parálisis y 24 con paresia). En cuanto a la desviación media y la moda según el grado de limitación, se evidenció mayor desviación en la lesión del III nervio. Conclusiones: Las desviaciones horizontales encontradas cuando existe daño al III nervio son en general de mayor magnitud que las encontradas cuando existe daño al VI nervio.
Purpose: To evaluate characteristics in the amount of deviation in III and VI nerve palsies, to establish a correlation between each one of clinical situations. Methods: Retrospective study where the files of patients with the diagnosis of III or VI nerve injury in the Hospital Nuestra Señora de La Luz were reviewed from january of 2000 to january of 2005. All patients had a complete ophthalmologic evaluation, in whitch the deviation was noticed, and in those with an affection of the III nerve the limitation of the adduction went from -4 or more, and in those with de VI nerve affected, the limitation of the abduction went from -4 or more. Results: 71 patients were included, 31 with III nerve injury and 40 with VI nerve injury. Conclusions: Horizontal deviations found in III nerve palsies are larger than those found in VI nerve palsies.