ABSTRACT
We report a case of congenital tuberculosis diagnosed by liver biopsy in a 8-week-old infant presented with acute abdomen. Liver biopsy showed multiple lymphoepitheloid cell granulomas with Langhans' giant cells and central necrosis. The culture of caseous material from the liver showed Mycobacterium tuberculosis . Antituberculous treatment was started. Endometrial biopsy in the asymptomatic mother confirmed the source of infection.
Subject(s)
Pregnancy Complications, Infectious , Tuberculosis, Female Genital/complications , Tuberculosis, Hepatic/congenital , Female , Humans , Infant , Male , Mycobacterium tuberculosis/isolation & purification , Pregnancy , Tuberculosis, Hepatic/diagnosisABSTRACT
Abdominal sonography of four infants with pyrexia and hepatomegaly demonstrated multiple hypoechoeic hepatic and splenic foci, guided biopsies of which showed caseating granulomas with acid-fast bacilli. Evidence of tuberculosis in maternal endometrium and its exclusion in the contacts further confirmed a diagnosis of congenital tuberculosis. Clinical suspicion supplemented by careful sonography facilitated early detection and antemortem diagnosis of this potentially fatal disease.
Subject(s)
Tuberculosis/congenital , Tuberculosis/diagnostic imaging , Female , Humans , Infant , Infant, Newborn , Male , Tuberculosis, Hepatic/congenital , Tuberculosis, Hepatic/diagnostic imaging , UltrasonographySubject(s)
Tuberculosis, Hepatic/congenital , Tuberculosis, Lymph Node/congenital , Tuberculosis, Miliary/congenital , Female , Follow-Up Studies , Humans , Infant, Newborn , Pregnancy , Pregnancy Complications, Infectious , Tuberculosis, Hepatic/diagnosis , Tuberculosis, Lymph Node/diagnosis , Tuberculosis, Miliary/diagnosis , Tuberculosis, Pleural/complicationsABSTRACT
A neonate presented with poor feeding, jaundice and hepatosplenomegaly. He was in liver failure with disseminated coagulopathy. Post-mortem liver biopsy revealed discrete granulomas with central necrosis and acid-fast bacilli on Ziehl-Nielsen's stain. The mother had active tuberculosis at delivery. The principal characteristics of congenital tuberculosis are reemphasized in this observation.
Subject(s)
Infant, Premature, Diseases/etiology , Infant, Premature , Tuberculosis/congenital , Adult , Female , Humans , Infant, Newborn , Male , Pregnancy , Tuberculosis/transmission , Tuberculosis, Hepatic/congenitalABSTRACT
A 7 week old baby presented with generalized lymphadenopathy, obstructive jaundice and massive hepatosplenomegaly. The clinical picture closely resembled a case of disseminated malignancy. Soon after the diagnosis of tuberculosis was made by pathological examination of a lymph node, the patient died. An autopsy revealed primary tuberculous foci in the liver and massive lymphadenopathy at the porta hepatis consistent with transplacentally acquired tuberculosis. The importance of early diagnosis and treatment of this rare condition is emphasized.
