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1.
J Am Geriatr Soc ; 72(4): 1166-1176, 2024 Apr.
Article in English | MEDLINE | ID: mdl-38401032

ABSTRACT

BACKGROUND: Prior studies indicated a link between urinary catheter use and urinary complications, highlighting the need for comprehensive, gender-specific investigations. This study explored the association through a national retrospective cohort, emphasizing gender disparities and long-term outcomes. METHODS: Our study utilized data from the entire population covered by Taiwan's National Health Insurance Research Database from 2000 to 2017. We included 148,304 patients who had undergone Foley catheter placement and their propensity-scores matched controls in the study. We evaluated urinary complications, which encompassed urinary tract cancer, urolithiasis, urethral stricture, obstructive uropathy, reflux uropathy, fistula, diverticulum, caruncle, false passage, prolapsed urethral mucosa, urinary tract rupture, and urinary tract infection. These were assessed using the Fine and Gray sub-distribution proportional hazards model to compare between the Foley and non-Foley groups. Sensitivity analyses were conducted with different matching ratios. RESULTS: In the study, the non-Foley group presented a marginally higher mean age (75.24 ± 10.47 years) than the Foley group (74.09 ± 10.47 years). The mean duration of Foley catheterization was 6.1 ± 4.19 years. Men with Foley catheterization exhibited the highest adjusted sub-distribution hazard ratios for urinary tract cancer (6.57, 95% CI: 5.85-7.37), followed by women with Foley catheterization (4.48, 95% CI: 3.98-5.05), and men without catheterization (1.58, 95% CI: 1.39-1.8) in comparison with women without the procedure. Furthermore, men with Foley catheterization were found to be at the greatest risk for complications such as urolithiasis, urethral stricture, obstructive and reflux uropathy, fistula, diverticulum, caruncle, false passage, prolapsed urethral mucosa, and urinary tract rupture. Conversely, women with urinary catheterization were most susceptible to urinary tract infections. CONCLUSIONS: The evidence confirms that urinary catheterization significantly increases urinary complications, particularly among men. Our study underscores the crucial need for healthcare providers to carefully evaluate the necessity of catheterization, aim to shorten its duration whenever feasible, and strictly adhere to established protocols to minimize complications.


Subject(s)
Diverticulum , Fistula , Urethral Stricture , Urinary Tract Infections , Urinary Tract , Urolithiasis , Urologic Neoplasms , Male , Humans , Female , Aged , Aged, 80 and over , Urinary Catheterization/adverse effects , Urinary Catheters/adverse effects , Catheters, Indwelling/adverse effects , Urethral Stricture/etiology , Urethral Stricture/complications , Retrospective Studies , Urinary Tract Infections/epidemiology , Urinary Tract Infections/etiology , Urolithiasis/complications , Urologic Neoplasms/complications , Diverticulum/complications , Fistula/complications
2.
Hinyokika Kiyo ; 70(1): 13-16, 2024 Jan.
Article in Japanese | MEDLINE | ID: mdl-38321744

ABSTRACT

We report two cases of ammonium acid urate stones that could not be diagnosed by dual-energy computed tomography (CT). Case 1: A 37-year-old female was referred to our hospital for a left kidney stone. She had a medical history of anorexia nervosa, Basedow's disease and hypoparathyroidism. Her height was 167 cm, weight 38 kg and body mass index (BMI) 13. 6. CT showed a left kidney stone measuring 18×12 mm. Dual-energy CT showed that the left kidney stone was composed of uric acid. Chemolysis by oral administration of alkaline citrate was attempted. Six months later, CT showed no improvement, and endoscopic combined intrarenal surgery (ECIRS) was performed. Stone analysis revealed pure ammonium acid urate. Case 2: A 42-year-old female was referred to our hospital because of right back pain. She had a medical history of ventricular septal defect and urolithiasis. Her height was 158 cm, weight 37 kg, and BMI 14.8. CT showed a right kidney stone measuring 16×12 mm. Dual-energy CT showed that the right kidney stone was composed of uric acid. Chemolysis by oral administration of alkaline citrate was attempted. Two months later, CT showed no improvement, and ECIRS was performed. Stone analysis revealed pure ammonium acid urate. It is difficult to differentiate uric acid stones and ammonium acid urate stones by dual-energy CT. Even when dual-energy CT suggests uric acid stones, ammonium acid urate stones should also be considered in thin young women and women with a history of anorexia nervosa.


Subject(s)
Kidney Calculi , Urinary Calculi , Urolithiasis , Adult , Female , Humans , Citrates , Tomography, X-Ray Computed/methods , Uric Acid , Urinary Calculi/complications , Urolithiasis/complications
3.
Urolithiasis ; 52(1): 28, 2024 Jan 20.
Article in English | MEDLINE | ID: mdl-38244096

ABSTRACT

The relationship between urinary tract infection caused by urease-producing bacteria and lithiasis due to struvite stones is well established in the literature. However, there is limited knowledge on whether non-urease producing bacteria can also promote crystallization. In our study, we analyzed the association between urinary lithiasis, other than struvite by crystallography and non-ureolytic bacteria, in 153 patients who underwent surgery for urinary stone. The collected samples were sent for crystallographic analysis and culture. Additionally, preoperatory urine culture was collected for combined evaluation with the previous data. Percutaneous nephrolithotomy was the most commonly performed approach (45.8%). Struvite stones were more frequently identified in women (90.3%). Among stones with positive cultures, except struvite, 45.5% were composed of calcium oxalate monohydrate. The difference between urine culture and stone culture was different in 24.8% of the cases. Among stones with positive cultures that did not contain struvite, 86.4% showed non-urease bacteria in their cultures and 47.1% of struvite stones also did not have urease-producing bacteria in their cultures (p < 0.021). Our findings suggest that there is an association between non-ureolytic bacteria and stones that are not composed of struvite.


Subject(s)
Urinary Calculi , Urolithiasis , Humans , Female , Struvite , Crystallography , Urease , Urolithiasis/complications , Urinary Calculi/urine , Bacteria
4.
Intern Med ; 63(3): 439-442, 2024 Feb 01.
Article in English | MEDLINE | ID: mdl-37344433

ABSTRACT

A 44-year-old man with osteogenesis imperfecta presented with left renal colic. Non-contrast computed tomography revealed a stone (10×9 mm) in the left upper ureter. Ureteroscopic lithotripsy was performed twice and stone-free status was achieved. An analysis of the stone revealed a mixed composition including calcium oxalate and calcium phosphate. Postoperatively, we administered bisphosphonates to prevent recurrence of urolithiasis, as 24-hour urine collection revealed marked hypercalciuria. Eighteen months after surgery, the urinary calcium levels had normalized, and there was no recurrence of urolithiasis. Osteogenesis imperfecta can be complicated by urolithiasis, but bisphosphonates may be useful in preventing recurrence of this disease.


Subject(s)
Osteogenesis Imperfecta , Urolithiasis , Male , Humans , Adult , Diphosphonates/therapeutic use , Osteogenesis Imperfecta/complications , Osteogenesis Imperfecta/drug therapy , Urolithiasis/complications , Urolithiasis/drug therapy , Kidney , Calcium Oxalate/analysis , Calcium
5.
J Dermatol ; 51(2): 280-286, 2024 Feb.
Article in English | MEDLINE | ID: mdl-38087833

ABSTRACT

The aim of the present study was to investigate whether patients with psoriasis are prone to urolithiasis. Prospective analysis of 67 patients diagnosed as psoriasis (PS group) and 65 volunteers who had never been diagnosed as psoriasis (NPS group) was performed. The levels of oxalate, citrate, calcium, uric acid, magnesium, creatinine, and sodium were evaluated by analyzing the 24-h urine samples. Stone events were detected in 13 patients (19.4%) in the PS group and in five participants (7.7%) in the NPS group, respectively (P < 0.05). The median value of 24-h citrate was significantly lower in the PS group than in the NPS group (P = 0.029). The median value of 24-h urine uric acid was significantly higher in the PS group than the NPS group (P = 0.005). Hypernatriuria was significantly higher in the PS group (P = 0.027). Hyperuricosuria was detected in the 10.4% and 1.5% of patients who had severe and mild disease, respectively (P = 0.027). Patients with psoriasis are more prone to urolithiasis. Hypocitraturia, hyperuricosuria, and hypernatriuria were the main metabolic abnormalities detected in psoriasis. Hyperuricosuria has been associated with the severity of the disease.


Subject(s)
Psoriasis , Urolithiasis , Humans , Uric Acid/metabolism , Calcium Oxalate/urine , Urolithiasis/etiology , Urolithiasis/complications , Citric Acid , Citrates/urine , Psoriasis/complications , Psoriasis/epidemiology , Risk Factors
6.
Int Urol Nephrol ; 56(4): 1217-1225, 2024 Apr.
Article in English | MEDLINE | ID: mdl-38038823

ABSTRACT

OBJECTIVE: Parathyroidectomy (PTX) is the conclusive therapy for primary hyperparathyroidism (PHPT), but its effect on the risk of urolithiasis is inconclusive. We comprehensively reviewed the currently available research to investigate the impact of PTX on the likelihood of urolithiasis among individuals suffering PHPT. METHODS: Internet-based articles in English language released on Cochrane, PubMed, Scopus, Web of knowledge, and Embase up to September, 2023 were comprehensively reviewed. Each publication in contrast to the incidence, occurrence, or recurrence of urolithiasis after PTX versus medical treatment in PHPT patients was included. The outcome with pooled relative risks (RRs) and corresponding 95% confidence intervals (CIs) was examined employing DerSimonian and Laird's model of random effects. To determine the range of the real effect size of a future study in 95% of all populations, a prediction interval (PI) was also established. RESULTS: Finally, ten studies involving 74,190 patients were included. Results from randomized-controlled trials (RCTs) and observational studies (OSs) both revealed that PTX did not substantially lessen the vulnerability of urolithiasis among individuals with PHPT (RCTs: pooled relative risk [RR] 0.42, 95%CI 0.13-1.41, p = 0.163; OSs: pooled RR 1.37, 95%CI 0.96 to 1.97, p = 0.084). The PI (RCT: 0.03 to 5.96; OSs: 0.44-4.20) containing 1.0 suggested the possibility of consistent results in future studies. Subgroup and sensitivity analyses supported the above findings, and no evidence showed publication bias. CONCLUSION: Our analysis from the available RCTs or OSs did not give adequate or exact proof that the average effect of PTX lowers the incidence of urolithiasis among PHPT persons based on the random-effects model. Future research shall take into account the common effect of PTX as well as the prerequisites of preventive stone procedures, which will further help us assess the effectiveness of PTX in reducing kidney calculus comorbidity and develop techniques to avoid stone sequelae in these individuals.


Subject(s)
Hyperparathyroidism, Primary , Kidney Calculi , Urolithiasis , Humans , Hyperparathyroidism, Primary/complications , Hyperparathyroidism, Primary/surgery , Parathyroidectomy/adverse effects , Urolithiasis/surgery , Urolithiasis/complications , Kidney Calculi/complications
7.
Actas Urol Esp (Engl Ed) ; 48(3): 204-209, 2024 Apr.
Article in English, Spanish | MEDLINE | ID: mdl-37838327

ABSTRACT

OBJECTIVES: This study evaluates the impact of using an access sheath (AS) during flexible ureteroscopy (fURS) for urolithiasis treatment, focusing on outcomes such as stone-free rate, operation time, and complications. METHODS: This prospective, randomized study was carried out at Badr Hospital, Helwan University, and Ain Shams University hospitals from August 2021 to August 2022. Patients were systematically randomized into two groups (fURS with AS: 33 patients and without AS: 31 patients) and underwent preoperative and postoperative assessments, including lab tests and imaging. Possible procedure-associated risks, such as failed stone access, pain, bleeding, and sepsis, were monitored. RESULTS: The two groups were found to be comparable in terms of demographic characteristics or preoperative stone findings (p > 0.05 for all). However, operation duration was shorter in the No Sheath group (79.4 ±â€¯15.3 min vs. 90.4 ±â€¯16.7 min in the Sheath group, p = 0.008). Intraoperative complication rates, including failed access, operation termination, ureteric injury, and bleeding, were comparable in both groups (p > 0.05). Postoperative stone-free rates (78.8% vs. 71.0%, p = 0.305) and mean residual stone size (2.7 ±â€¯3.5 mm vs. 3.1 ±â€¯3.1 mm, p = 0.687) showed no significant differences. CONCLUSIONS: The present study suggests that fURS without an access sheath may offer an efficient and equally effective option for managing upper ureteric and renal stones. However, more studies with larger sample sizes and longer follow-up periods are required to validate these findings and to establish more precise indications for this approach.


Subject(s)
Kidney Calculi , Ureter , Urolithiasis , Humans , Ureteroscopy/methods , Ureteroscopes , Ureter/surgery , Kidney Calculi/surgery , Urolithiasis/surgery , Urolithiasis/complications
8.
Int Urol Nephrol ; 56(5): 1611-1616, 2024 May.
Article in English | MEDLINE | ID: mdl-38123734

ABSTRACT

PURPOSE: To identify the risk factors for perioperative complications to prevent perioperative complications after complete ipsilateral upper urinary stone removal using flexible ureterorenoscopy. MATERIALS AND METHODS: We retrospectively examined 111 patients who underwent flexible ureterorenoscopy for ipsilateral renal stones with a diameter ≥ 5 mm at the same time as ureterorenoscopy for ureteric stones. The flexible ureterorenoscopy procedures were performed following the fragmentation technique. Patients who experienced (complication group) and did not experience (non-complication group) perioperative complications were compared. The complication group included 33 patients with Clavien-Dindo classification scores of I, II, III, or IV and/or those with a body temperature of > 37.5 â„ƒ during hospitalization. RESULTS: The overall stone volume, stone-free rate and procedure duration were 1.71 mL, 96.4% and 77 min, respectively. The rate of perioperative complications was 29.7% (grade 1, 2 and 3 was 23.4%, 5.4% and 0.9%, respectively). Severe complications (Clavien-Dindo grade 4) were not observed. Multivariable analysis revealed that ureteral stone volume and female patients were independent predictors of perioperative complications after flexible ureterorenoscopy (p = 0.015 and 0.017, respectively). CONCLUSIONS: This study showed that ureteral stone volume and female gender have the possibility to increase perioperative complications. These preliminary data help to select for patients who are at low risk of complications. Therefore, in these selected patients, complete ipsilateral upper urinary tract stone removal using flexible ureterorenoscopy may reduce the recurrence of urolithiasis without increasing perioperative complications.


Subject(s)
Kidney Calculi , Ureteral Calculi , Urolithiasis , Humans , Female , Retrospective Studies , Ureteroscopy/adverse effects , Ureteroscopy/methods , Ureteral Calculi/surgery , Ureteral Calculi/complications , Kidney Calculi/complications , Urolithiasis/complications , Treatment Outcome
9.
Am J Emerg Med ; 75: 137-142, 2024 01.
Article in English | MEDLINE | ID: mdl-37950981

ABSTRACT

INTRODUCTION: Infected urolithiasis is a serious condition that carries with it a high rate of morbidity and mortality. OBJECTIVE: This review highlights the pearls and pitfalls of infected urolithiasis, including presentation, diagnosis, and management in the emergency department based on current evidence. DISCUSSION: Although urolithiasis is common and the vast majority can be treated conservatively, the presence of a concomitant urinary tract infection significantly increases the risk of morbidity, to include sepsis and mortality. Identification of infected urolithiasis can be challenging as patients may have symptoms similar to uncomplicated urolithiasis and/or pyelonephritis. However, clinicians should consider infected urolithiasis in toxic-appearing patients with fever, chills, dysuria, and costovertebral angle tenderness, especially in those with a history of recurrent urinary tract infections. Positive urine leukocyte esterase, nitrites, and pyuria in conjunction with an elevated white blood cell count may be helpful to identify infected urolithiasis. Patients should be resuscitated with fluids and broad-spectrum antibiotics. Additionally, computed tomography and early urology consultation are recommended to facilitate definitive care. CONCLUSIONS: An understanding of infected urolithiasis can assist emergency clinicians in diagnosing and managing this potentially deadly disease.


Subject(s)
Pyelonephritis , Pyuria , Urinary Tract Infections , Urolithiasis , Humans , Prevalence , Urinary Tract Infections/diagnosis , Urinary Tract Infections/epidemiology , Urolithiasis/complications , Urolithiasis/diagnosis , Urolithiasis/epidemiology
10.
J Am Coll Radiol ; 20(11S): S315-S328, 2023 11.
Article in English | MEDLINE | ID: mdl-38040458

ABSTRACT

Noncontrast CT (NCCT) is the imaging study of choice for initial evaluation of patients with acute onset of flank pain and suspicion of stone disease without known prior stone disease. NCCT can reliably characterize the location and size of an offending ureteral calculus, identify complications, and diagnose alternative etiologies of abdominal pain. Although less sensitive in the detection of stones, ultrasound may have a role in evaluating for signs of obstruction. Radiography potentially has a role, although has been shown to be less sensitive than NCCT. For patients with known disease and recurrent symptoms of urolithiasis, NCCT remains the test of choice for evaluation. In pregnancy, given radiation concerns, ultrasound is recommended as the initial modality of choice with potential role for noncontrast MRI. In scenarios where stone disease suspected and initial NCCT is inconclusive, contrast-enhanced imaging, either with MRI or CT/CT urogram may be appropriate. The American College of Radiology Appropriateness Criteria are evidence-based guidelines for specific clinical conditions that are reviewed annually by a multidisciplinary expert panel. The guideline development and revision process support the systematic analysis of the medical literature from peer reviewed journals. Established methodology principles such as Grading of Recommendations Assessment, Development, and Evaluation or GRADE are adapted to evaluate the evidence. The RAND/UCLA Appropriateness Method User Manual provides the methodology to determine the appropriateness of imaging and treatment procedures for specific clinical scenarios. In those instances where peer reviewed literature is lacking or equivocal, experts may be the primary evidentiary source available to formulate a recommendation.


Subject(s)
Acute Pain , Urolithiasis , Humans , Abdominal Pain , Flank Pain/diagnostic imaging , Flank Pain/etiology , Magnetic Resonance Imaging/methods , Radiography , Societies, Medical , United States , Urolithiasis/complications , Urolithiasis/diagnostic imaging
11.
Acta Vet Scand ; 65(1): 47, 2023 Nov 14.
Article in English | MEDLINE | ID: mdl-37964384

ABSTRACT

BACKGROUND: Urinary tract problems are a common complaint in small animal medicine and urolithiasis is considered to be an important cause of urinary tract disease in dogs. In this study the main aim was to investigate whether the occurrence of cystine urolithiasis increased during a five-year period. A second aim was to evaluate possible risk-factors as breed, age and gender. This study also evaluated how urine specific gravity, pH and level of cystine in urine responded to preventive strategies. Medical records of dogs with urolithiasis presented at nine Norwegian animal clinics and one animal hospital between 2015 and 2020 were retrospectively reviewed. RESULTS: The incidence of cystine uroliths increased significantly during the five study years (R2 = 0.72, P = 0.0199). Dogs with cystine uroliths were significantly younger (5.0 years (n = 84, 95% CI [4.4-5.6])) when they were diagnosed with cystine uroliths compared to dogs with other types of uroliths (8.1 years (n = 255, 95% CI[7.8-8.5]) P < < 0.0001). Cystine levels in urine were increased in 93% of the dogs with cystine urolithiasis. Cystinuria decreased significantly after neutering (P < 0.0001). Breeds most commonly affected with cystine urolithiasis in this study were Staffordshire bull terrier, Danish Swedish farmdog and Chihuahua. CONCLUSIONS: The results from this study supports a suggested genetic basis for cystine urolithiasis as described in previous studies. Neutering is considered an important part of preventing reoccurrence since cystine values decreased significantly after neutering.


Subject(s)
Dog Diseases , Urinary Calculi , Urolithiasis , Dogs , Animals , Retrospective Studies , Cystine/analysis , Dog Diseases/diagnosis , Urinary Calculi/epidemiology , Urinary Calculi/veterinary , Urinary Calculi/complications , Urolithiasis/epidemiology , Urolithiasis/veterinary , Urolithiasis/complications , Norway/epidemiology
12.
Front Public Health ; 11: 1203640, 2023.
Article in English | MEDLINE | ID: mdl-37965514

ABSTRACT

Introduction and objectives: Somalia was predicted to be in the global stone belt with high urolithiasis prevalence. We aimed to determine the prevalence of urolithiasis and their demographic and computer tomography (CT) characteristics among subjects under CT scans in Mogadishu, Somalia. Materials and Methods: From March 2014 to November 2022, a total of 7,276 patients who underwent an abdominopelvic non-contrast CT scan for various indications were retrospectively reviewed. The mean age was 45.6 years with a standard deviation of 21.1 (range, 0.2-110 years). Patients were subdivided into two categories: adults (≥18 years) and pediatric (≤17 years). Results: Of the 7,276 patients, 1,075 (14.8%) were diagnosed with urolithiasis. Among those with urolithiasis, 702 (65.3%) were male patients, and 373 (34.7%) were female patients. Among them, adults accounted for 92.7%, while children were 7.3%. Renal stones (nephrolithiasis) were the most common, representing 57% followed by ureteric stones at 35.5%, making upper urinary stones 92.5%. Approximately 70 patients (6.5%) had bladder stones; of these, 26 of them (37%) were accompanied by benign prostatic hyperplasia (BPH). There were 10 urethral stones (0.9%) recorded in the study, all were found in male patients, 8 localized in prostatic urethra, and 2 in the bulbar urethra. The overall mean stone size was 13.2 mm, and 60% of them ranged from 5 to 22 mm. Only 24% of the patients were asymptomatic. Single stones were almost 70%, while staghorn calculi were 8.2%. More than 60% of the patients with urolithiasis showed some degree of hydronephrosis ranging between mild to severe. Conclusion: A CT scan-based urolithiasis prevalence indicates 14.8% in Mogadishu, Somalia, and these results are consistent with the probability calculation of the weights-of-evidence (WofE) methodology based on several risk factors including temperature, climate change, mineral deposit, drinking water quality, and distribution of carbonated rocks. Considering the high prevalence of the disease, Somalia needs to invest more in prevention and treatment facilities while also training urologists that are capable of utilizing minimally invasive techniques in the country.


Subject(s)
Urinary Calculi , Urolithiasis , Adult , Humans , Male , Female , Child , Middle Aged , Retrospective Studies , Prevalence , Somalia/epidemiology , Urolithiasis/diagnostic imaging , Urolithiasis/epidemiology , Urolithiasis/complications , Urinary Calculi/complications , Urinary Calculi/surgery , Tomography, X-Ray Computed/methods , Referral and Consultation
13.
Prog Urol ; 33(14): 791-811, 2023 Nov.
Article in English | MEDLINE | ID: mdl-37918980

ABSTRACT

The acute situation, caused by an obstructive stone, is defined by a renal colic that may be uncomplicated, complicated, or at risk in specific conditions. Its management may be medical or require interventional treatment by extracorporeal shockwave lithotripsy, endoscopic removal, or ureteroscopy. METHODOLOGY: These recommendations were developed using two methods, the Clinical Practice Recommendations (CPR) and the ADAPTE method, in function of whether the question was considered in the European Association of Urology (EAU) recommendations (https://uroweb.org/guidelines/urolithiasis) [EAU Guidelines on urolithiasis. 2022] and whether they could be adapted to the French context.


Subject(s)
Lithiasis , Lithotripsy , Urinary Calculi , Urolithiasis , Urology , Humans , Lithiasis/therapy , Urolithiasis/complications , Urolithiasis/diagnosis , Urolithiasis/therapy , Urinary Calculi/therapy , Ureteroscopy
14.
Prog Urol ; 33(14): 875-882, 2023 Nov.
Article in English | MEDLINE | ID: mdl-37918987

ABSTRACT

Chronic kidney disease, diabetes and hypertension are risk factors of kidney function impairment. The relative risk of kidney failure is 1.52 in patients with urinary stone disease. The various techniques used to remove upper urinary tract stones generally do not alter kidney function in patients with normal kidney function and may sometimes improve kidney function or slow its deterioration in patients with kidney disease. Compared to the asynchronous treatment of bilateral renal and ureteral stones, concomitant treatment is associated with higher risk of anuria and the need of additional interventions, in the absence of postoperative stenting. For the treatment of solitary kidney stones, the absence of postoperative stenting increases the risk of postoperative anuria. Moreover, the multiplication of percutaneous nephrolithotomy access tracts increases the risk of bleeding and that of kidney function impairment. METHODOLOGY: These recommendations were developed according to two methods: the Clinical Practice Recommendations (CPR) method and the ADAPTE method, depending on whether the question was considered in the European Association of Urology (EAU) recommendations (https://uroweb.org/guidelines/urolithiasis) [EAU Guidelines on urolithiasis. 2022] and their adaptability to the French context.


Subject(s)
Anuria , Kidney Calculi , Lithiasis , Renal Insufficiency, Chronic , Solitary Kidney , Urinary Calculi , Urolithiasis , Humans , Solitary Kidney/complications , Lithiasis/complications , Anuria/complications , Anuria/surgery , Urolithiasis/complications , Urolithiasis/diagnosis , Urinary Calculi/surgery , Kidney Calculi/complications , Kidney Calculi/therapy , Renal Insufficiency, Chronic/complications , Renal Insufficiency, Chronic/therapy
15.
Hinyokika Kiyo ; 69(9): 239-242, 2023 Sep.
Article in Japanese | MEDLINE | ID: mdl-37794673

ABSTRACT

We retrospectively evaluated the safety and effectiveness of retrograde ureteroscopy via ileal conduit construction. Between January 2014 and December 2021, 5 patients (8 procedures) with ileal conduit construction received retrograde ureteroscopic lithotripsy with a 11/13 Fr ureteral access sheath. At postoperative 1 month, a plain computed tomography (CT) and kidney, ureter, and bladder X-ray (KUB) were performed to assess stone fragmentation and hydronephrosis. According to postoperative imaging, stone-free was defined as residual fragments of 4 mm or less on KUB and 2 mm or less on CT. The mean stone size was 11 mm (6-13 mm). The mean stone volume was 1. 51 ml (0.33-2.56 ml). The mean operative time was 91 min (60-133 min). SFR was 100% on KUB and 87.5% on CT. One procedure (12.5%) resulted in a postoperative fever greater than 38.5℃. There were no complications of grade III or higher according to the modified Clavien-Dindo classification. No exacerbation of hydronephrosis was observed on CT. Retrograde ureteroscopy with a ureteral access sheath was found to be effective for urolithiasis in patients with ileal conduit.


Subject(s)
Hydronephrosis , Lithotripsy , Ureter , Ureteral Calculi , Urinary Calculi , Urinary Diversion , Urolithiasis , Humans , Ureteroscopy/adverse effects , Ureteroscopy/methods , Ureter/diagnostic imaging , Ureter/surgery , Ureteral Calculi/complications , Ureteral Calculi/surgery , Retrospective Studies , Urinary Calculi/complications , Urolithiasis/complications , Lithotripsy/adverse effects , Lithotripsy/methods , Hydronephrosis/etiology , Urinary Diversion/adverse effects , Treatment Outcome
16.
Georgian Med News ; (340-341): 191-197, 2023.
Article in English | MEDLINE | ID: mdl-37805897

ABSTRACT

The aim of the work is to improve the results of early diagnosis of acute infectious kidney diseases at the molecular level in urolithiasis (urinary stone disease) through the study of enzymatic test indicators. Enzymatic tests (NGAL, IL-1ß, ß2-microglobulin) were investigated at the molecular level using the IFA method in the urine of patients with urolithiasis. Comparative and prognostic significance of the conducted treatment was established between the groups of patients, and an algorithm was developed based on the results of kidney damage predictors. It was found that the indicators of general laboratory analysis in patients with urolithiasis within the first 24-48 hours do not reliably indicate the absence of an infectious-inflammatory process in the kidneys and the development of renal failure. It was determined that an increase in the inflammation predictor indicators in more than 50% of patients indicates the development of infectious-inflammatory complications within the first 12-24 hours before the occurrence of general laboratory and clinical changes. The assessment of the effectiveness of conservative therapy in groups IA and II revealed that complications of the inflammatory process in the kidneys were observed five times more frequently in group II (comparison) than in group IA. The use of enzymatic tests as markers for early kidney damage allows for the classification of two main groups of patients: those requiring conservative treatment and those requiring urgent surgical intervention. This significantly reduces the frequency of inflammatory, purulent-septic complications and improves the treatment outcomes for patients with upper urinary tract obstruction in urolithiasis.


Subject(s)
Kidney Diseases , Urolithiasis , Humans , Urolithiasis/diagnosis , Urolithiasis/complications , Urolithiasis/epidemiology , Kidney , Prognosis , Inflammation/complications
17.
Sci Rep ; 13(1): 17686, 2023 10 17.
Article in English | MEDLINE | ID: mdl-37848540

ABSTRACT

Urolithiasis is associated with an increased risk of chronic kidney disease (CKD), irrespective of stone compositions. Chronic inflammation is an important factor for CKD progression. Neutrophil-to-lymphocyte ratio (NLR) has been recognized as a reliable biomarker of inflammation, yet its use in predicting renal deterioration in patients with urolithiasis remains limited. We aimed to explore whether the combination of stone composition and NLR could be useful as a predictor for CKD risk. A total of 336 stone formers with at least one stone submission for analysis were enrolled in the retrospective study. Stones were classified into uric acid and calcium groups. Renal functions were assessed at least one month after stone treatment. Uric acid stone formers had significantly lower estimated glomerular filtration rate (eGFR) compared with calcium stone formers (p < 0.001). NLR was significantly higher in uric acid stone formers (p = 0.005), and a significantly negative correlation (p < 0.001) between NLR and eGFR had been observed only in uric acid stone group. Univariate and multivariate logistic regression analyses showed that higher proportion of uric acid stone composition and higher NLR were both significantly associated with CKD risks. A nomogram integrating independent predictors was generated for CKD prediction, yielding an AUC of 0.811 (0.764-0.858). In conclusion, our study demonstrated that stone formers with higher proportion of uric acid composition and higher NLR levels were associated with higher CKD risk.


Subject(s)
Kidney Calculi , Renal Insufficiency, Chronic , Urolithiasis , Humans , Uric Acid , Calcium , Retrospective Studies , Neutrophils , Kidney Calculi/complications , Renal Insufficiency, Chronic/complications , Urolithiasis/complications , Inflammation/complications , Lymphocytes
18.
Urologiia ; (4): 136-140, 2023 Sep.
Article in Russian | MEDLINE | ID: mdl-37850294

ABSTRACT

Today, the total number of people living with the human immunodeficiency virus (HIV) is 43.8 million. From the moment of infection to the terminal stage of the disease, the risk of stone formation progressively increases. A prevalence and role of individual risk factors for urolithiasis in patients with HIV are reviewed in the article. It is shown that in HIV-positive individuals, urolithiasis takes a leading position among renal diseases, with a prevalence ranging from 8 to 27%. The main risk factors for urolithiasis in HIV are: dietary factors, age, comorbid pathologies, use of protease inhibitors, changes in the ionic composition of urine, etc.


Subject(s)
HIV Infections , Urolithiasis , Humans , Prevalence , Urolithiasis/complications , Urolithiasis/epidemiology , Risk Factors , HIV Infections/complications , HIV Infections/epidemiology
20.
Cir. pediátr ; 36(4): 171-179, Oct. 2023. tab, graf
Article in Spanish | IBECS | ID: ibc-226518

ABSTRACT

Objetivos: El uso de catéteres doble J (DJ) es un proceso frecuenteen uropediatría, pero no exento de morbilidad. El objetivo de nuestroestudio es describir factores de riesgo (FR) de complicación de losDJ en pacientes pediátricos y comprobar la calidad de la informacióntransmitida a las familias en relación al catéter. Material y métodos: Estudio retrospectivo de pacientes intervenidos en urología con colocación de DJ (2017–2022). Grupos a estudio: complicados (CC) y no complicados (SC). Realizamos un análisismultivariante para identificar FR relacionados con complicaciones yun análisis de calidad percibida por las familias mediante encuesta desatisfacción (0 no satisfacción, 10 máxima satisfacción).Resultados. Incluimos 180 pacientes, (236 DJ). Diagnósticos principales: trasplante renal 29,8%, estenosis pieloureteral 26%, y urolitiasis20,7%. La tasa de complicaciones fue del 21,9%, con un ComprehensiveComplication Index (CCI) medio de 26,8. La antibioterapia profilácticano se relaciona con menos complicaciones (97,3% vs 98,1% p= 0,727). FR de complicación: acumular más de un catéter (p< 0,001, OR 6,628)o la colocación bilateral (p< 0,05; OR 4,871). Un mal registro en lahistoria clínica se relacionó con más complicaciones (p= 0,025). Enla encuesta de calidad de información recibida, el 20% reflejaron unapuntuación inferior a 7/10. Conclusiones: La morbilidad asociada al DJ se relaciona con suduración, la bilateralidad o acumular más de un catéter. Su adecuadoregistro en la historia clínica se relaciona con menor duración del mismo y, por tanto, menos complicaciones. La profilaxis antibiótica no hademostrado disminuir las complicaciones, su uso rutinario debe serrevalorado.(AU)


Objective: The use of double J (DJ) stents is frequent in urologicalpediatrics, but it is not exempt from morbidity. The objective of this studywas to describe the risk factors (RF) of DJ complications in pediatricpatients, and to analyze the quality of the information provided to thefamilies with respect to the stent.Materials and methods: A retrospective study of patients undergoing surgery with DJ placement in the urology department from 2017to 2022 was carried out. Study patients were divided into two groups –complicated (C) and non-complicated (NC). A multivariate analysis wasperformed to identify complication-related RFs, and a quality analysisas perceived by the families was conducted by means of a satisfactionsurvey (0 = total dissatisfaction; 10 = maximum satisfaction). Results: 180 patients were included (236 DJs). The main diagnosesincluded renal transplantation (29.8%), ureteropelvic stenosis (26%), andurolithiasis (20.7%). Complication rate was 21.9%, with a mean comprehensive complication index (CCI) of 26.8. Prophylactic antibiotic therapywas not associated with fewer complications (97.3% vs. 98.1%; p=0.727). Complication RFs included more than one stent (p<0.001; OR=6.628)and bilateral placement (p<0.05; OR=4.871). Poor registration in themedical records was associated with greater complications (p=0.025). Inthe information quality survey, 20% reported a score lower than 7/10.Conclusions: DJ-associated morbidity has a direct relationshipwith DJ duration, bilaterality, and carrying more than one stent in alifetime. Adequate registration in the medical records is associatedwith shorter DJ duration, and therefore, fewer complications. Antibiotic prophylaxis did not reduce complications, which means its routineuse should be reconsidered.(AU)


Subject(s)
Humans , Male , Female , Child , Adolescent , Urologic Surgical Procedures/methods , Quality of Life , Intraoperative Complications/surgery , Urinary Catheters , Urinary Catheterization , Urology , General Surgery , Pediatrics , Risk Factors , Catheters , Urolithiasis/complications , Kidney Transplantation
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