ABSTRACT
For the evaluation of the potential carcinogenic properties of TPP the Syrian hamster embryo cell transformation test was employed. TPP did not induce morphological cell transformation in these cells.
Subject(s)
Amino Acids/toxicity , Carbohydrates/toxicity , Carcinogens/toxicity , Cell Transformation, Neoplastic/chemically induced , Humic Substances/toxicity , Uronic Acids/toxicity , Animals , Benzo(a)pyrene/toxicity , Cells, Cultured , Cricetinae , Cryopreservation , Drug Combinations , Mesocricetus/embryology , SoilABSTRACT
The systemic toxicity of the peat preparation in rats and rabbits was assessed. Dermal irritation tests were conducted on rabbits. In acute and chronic toxicity studies TPP was well tolerated in both animal species. Laboratory findings revealed no hematologic abnormalities as well as disturbances in liver and kidney function. No local irritancy of TPP was found. The results show that TPP may be considered as practically non toxic.
Subject(s)
Amino Acids/toxicity , Carbohydrates/toxicity , Humic Substances/toxicity , Uronic Acids/toxicity , Animals , Drug Combinations , Female , Irritants , Kidney/drug effects , Liver/drug effects , Male , Rabbits , Rats , Skin/drug effects , SoilABSTRACT
For evaluation of mutagenic and genotoxic properties of Tolpa Peat Preparation (TPP) four selected short-term tests were employed. TPP has been found to be neither mutagenic nor genotoxic.
Subject(s)
Amino Acids/toxicity , Carbohydrates/toxicity , Humic Substances/toxicity , Liver/drug effects , Mutagens/toxicity , Uronic Acids/toxicity , Animals , Cell Line , DNA/biosynthesis , DNA Repair/drug effects , Drug Combinations , Humans , Male , Mutagenicity Tests , Rats , Rats, Wistar , SoilABSTRACT
Neither embryotoxic nor teratogenic effects were observed in hamsters and rats after administration of Tolpa Peat Preparation (TPP) in doses of 5 and 50 mg/kg daily. Some maternal toxicity in rats and some embryotoxic effect in hamsters were recorded after the highest dose of TPP (250 mg/kg daily).
Subject(s)
Amino Acids/toxicity , Carbohydrates/toxicity , Embryonic and Fetal Development/drug effects , Humic Substances/toxicity , Teratogens/toxicity , Uronic Acids/toxicity , Abnormalities, Drug-Induced/etiology , Animals , Cricetinae , Drug Combinations , Female , Pregnancy , Rats , SoilSubject(s)
Blood Cell Count , Hematocrit , Uronic Acids/toxicity , Animals , Female , Injections, Intraperitoneal , Male , Rabbits , Rats , Rats, Inbred Strains , Uronic Acids/administration & dosageABSTRACT
Carbohydrates in some pollen substitutes (galactose, lactose, raffinose, stachyose, glucuronic acid, galacturonic acid, polygalacturonic acid, and pectin) were toxic to caged adult Apis mellifera L. These toxins can be diluted to safe levels by sucrose. Collected nectar apparently dilutes the toxic sugars in pollen thus permitting assimilation of essential nutrients from pollen.
