ABSTRACT
Cervical ectopy is common in adolescents, pregnant women, and those taking high doses of estrogen-containing contraceptives. The majority of cases have spontaneous reversion, but some cases can be persistent. Studies suggested that the adequacy of a Pap smear could be affected and there is an increased risk cervical infections. This study is a cross-sectional study conducted from December 2009 to February 2011 with 457 women with cervical ectopy and 736 without ectopy. Cervical samples were collected in vials for analysis by ThinPrep cytology (Hologic, Marlborough, MA). The Mann-Whitney test and Fisher's exact test (95% CI) were applied. The study was approved by the ethics committee of the Federal University of Ceará. The mean ages of the study group and control group were 28.7 (±14.8) and 33.6 (±7.5) years old, respectively (P < 0.0001). Negative diagnosis for malignancy and intraepithelial lesion was present in 399 (87%) cases and 705 (96%) in the study and control groups, respectively (P < 0.0001). Shift in the flora suggestive of bacterial vaginosis (BV) was observed more frequently in the study group: 74 (16.2%) than in the control group: 86(11.7%) (P = 0.017). The differences among the other morphotypes showed no significance. The smears were atypical in 12.7% (58/457) of the patients from the study group and in 4.2% (31/736) in the control group (P < 0.001; RR = 3 [2.033-4.712]). The association between ectopy and inflammatory cytology, the presence of the shift in the flora suggestive of BV and cytological atypia is evident.
Subject(s)
Uterine Cervical Dysplasia/pathology , Uterine Cervical Erosion/pathology , Uterine Cervical Neoplasms/pathology , Vaginosis, Bacterial/pathology , Adolescent , Adult , Bacteria, Anaerobic/growth & development , Case-Control Studies , Cervix Uteri/microbiology , Cervix Uteri/pathology , Cross-Sectional Studies , Female , Humans , Microscopy , Papanicolaou Test , Pregnancy , Uterine Cervical Erosion/diagnosis , Uterine Cervical Erosion/microbiology , Uterine Cervical Neoplasms/diagnosis , Uterine Cervical Neoplasms/microbiology , Vaginosis, Bacterial/diagnosis , Vaginosis, Bacterial/microbiology , Uterine Cervical Dysplasia/diagnosis , Uterine Cervical Dysplasia/microbiologySubject(s)
Uterine Cervicitis/therapy , Cervix Uteri/pathology , Chronic Disease , Diagnosis, Differential , Epithelium/pathology , Female , Humans , Uterine Cervical Diseases/diagnosis , Uterine Cervical Diseases/pathology , Uterine Cervical Diseases/therapy , Uterine Cervical Erosion/diagnosis , Uterine Cervical Erosion/pathology , Uterine Cervicitis/diagnosis , Uterine Cervicitis/pathologyABSTRACT
The purpose of this study was to determine the role of socio-economic factors and cytology in cervical erosion. A cross-sectional study involving 410 females in the reproductive age group was conducted in urban health centers in Hamedan city, Iran. Data were collected through interviews with women, gynecological examination in the clinics in the health centers and laboratory tests. Cervical erosion was detected in 68 (16.6%) females. Out of these mild dysplasia was seen in (8.8%) females. High percentages of inflammatory smears (58.8%) were obtained in women with cervical erosion. Cervical erosion was more common in illiterate and women with low literacy status as compared to women with higher education. Majority of cases of cervical erosion were detected in women with high parity. A statistically significant relationship was found between lower socio-economic status and cervical erosion (p < 0.05). Regular cytological screening by Pap smear will help in early detection of carcinoma cervix.
Subject(s)
Uterine Cervical Erosion/epidemiology , Female , Humans , Iran/epidemiology , Papanicolaou Test , Uterine Cervical Erosion/diagnosis , Uterine Cervical Erosion/pathology , Vaginal SmearsABSTRACT
The work presents the results of studies on the behaviour of SCC antigen in 52 patients aged 21-70 years, with pathologic changes involving the uterine cervix and classified to the groups of erosion, dysplasia and carcinoma in different stage of advancement. The SCC antigen was determined in patients blood sera by radioimmunologic method, on the basis of Abbott Firm testes. An increase in concentration was observed exceed the norm (2 ng/ml) in cases of CIN and CIS. The rise of marker depended on the stage of the neoplastic process advancement in the uterine cervix.
