ABSTRACT
Without appropriate treatment, Group A streptococcal infections can lead to post-streptococcal syndrome, including post-streptococcal uveitis. This should be kept in mind in young patients with acute bilateral non-granulomatous anterior uveitis, in order to avoid ocular and systemic complications. We report two cases of bilateral post-streptococcal anterior uveitis, in young men, of respectively 20 and 16 years old, that presented to Jules Gonin Eye Hospital.
Subject(s)
Anti-Bacterial Agents/administration & dosage , Streptococcal Infections/diagnosis , Streptococcal Infections/drug therapy , Uveitis, Suppurative/diagnosis , Uveitis, Suppurative/drug therapy , Administration, Ophthalmic , Adolescent , Diagnosis, Differential , Humans , Male , Rare Diseases/diagnosis , Rare Diseases/drug therapy , Rare Diseases/microbiology , Streptococcal Infections/microbiology , Treatment Outcome , Uveitis, Suppurative/microbiologyABSTRACT
PURPOSE: To report a case of hypopyon uveitis associated with systemic lupus erythematosus and antiphospholipid antibody syndrome. METHODS: Interventional case report: a 49-year-old woman with a history of systemic lupus erythematosus and antiphospholipid antibody syndrome presented with sudden onset of pain, redness, photophobia, and decreased vision in the left eye. Examination revealed hypopyon uveitis and vaso-occlusive retinopathy. RESULTS: Following treatment with intravenous steroids and cyclophosphamide, the patient's vision improved from CF to 20/80 with no inflammation 6 months following initial presentation. CONCLUSIONS: In this case, systemic lupus and antiphospholipid syndrome were associated with hypopyon uveitis. Prompt treatment with systemic immunosuppressive therapy resulted in improvement in the hypopyon uveitis and vaso-occlusive retinopathy.
Subject(s)
Antiphospholipid Syndrome/complications , Lupus Erythematosus, Systemic/complications , Uveitis, Suppurative/etiology , Antiphospholipid Syndrome/diagnosis , Antiphospholipid Syndrome/drug therapy , Cyclophosphamide/therapeutic use , Drug Therapy, Combination , Female , Fluorescein Angiography , Glucocorticoids/therapeutic use , Humans , Immunosuppressive Agents/therapeutic use , Lupus Erythematosus, Systemic/diagnosis , Lupus Erythematosus, Systemic/drug therapy , Middle Aged , Retinal Artery Occlusion/diagnosis , Retinal Artery Occlusion/drug therapy , Retinal Artery Occlusion/etiology , Retinal Vein Occlusion/diagnosis , Retinal Vein Occlusion/drug therapy , Retinal Vein Occlusion/etiology , Uveitis, Suppurative/diagnosis , Uveitis, Suppurative/drug therapy , Vision Disorders/etiology , Visual AcuityABSTRACT
Experimental uveitis is characterized by a pronounced lipid peroxidation (LPO) in damaged tissues of eye, which is complicated by reduced activity of the antioxidant enzymes, SOD and catalase. The intensification of LPO was also found in blood serum and hepatic tissue. However, hepatic lipid peroxidation was accompanied by compensatory increase of catalase activity. The activity of antioxidant defence enzymes decreased in blood, whereas catalase was activated in hepatic tissue. The therapeutic effect was accompanied by a decrease of LPO products and increase of activity of the antioxidant enzymes in all tissues. Treatment of uveitis with gentamycin and, especially, perftoran reduced inflammatory events.
