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Proc Natl Acad Sci U S A ; 109(50): 20566-71, 2012 Dec 11.
Article in English | MEDLINE | ID: mdl-23169669

ABSTRACT

The lung is an important entry site for pathogens; its exposure to antigens results in systemic as well as local IgA and IgG antibodies. Here we show that intranasal administration of virus-like particles (VLPs) results in splenic B-cell responses with strong local germinal-center formation. Surprisingly, VLPs were not transported from the lung to the spleen in a free form but by B cells. The interaction between VLPs and B cells was initiated in the lung and occurred independently of complement receptor 2 and Fcγ receptors, but was dependent upon B-cell receptors. Thus, B cells passing through the lungs bind VLPs via their B-cell receptors and deliver them to local B cells within the splenic B-cell follicle. This process is fundamentally different from delivery of blood or lymph borne particulate antigens, which are transported into B cell follicles by binding to complement receptors on B cells.


Subject(s)
B-Lymphocytes/immunology , B-Lymphocytes/virology , Vaccines, Virus-Like Particle/immunology , Administration, Intranasal , Adoptive Transfer , Animals , Antibodies, Viral/biosynthesis , Antigens, Viral/administration & dosage , Antigens, Viral/blood , Cell Movement/immunology , Female , Immunoglobulin G/biosynthesis , Lung/immunology , Lung/virology , Mice , Mice, Inbred C57BL , Receptors, Antigen, B-Cell/immunology , Receptors, Complement 3d/immunology , Receptors, IgG/immunology , Spleen/immunology , Spleen/virology , Vaccines, Virus-Like Particle/administration & dosage , Vaccines, Virus-Like Particle/blood
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