Subject(s)
Hemangiopericytoma/diagnostic imaging , Vaginal Neoplasms/diagnostic imaging , Adult , Cesarean Section , Female , Hemangiopericytoma/congenital , Hemangiopericytoma/pathology , Hemangiopericytoma/surgery , Humans , Imaging, Three-Dimensional , Magnetic Resonance Imaging , Pregnancy , Treatment Outcome , Ultrasonography, Doppler , Ultrasonography, Prenatal , Vaginal Neoplasms/congenital , Vaginal Neoplasms/pathology , Vaginal Neoplasms/surgeryABSTRACT
Although rare, sarcoma botryoides of the vagina in infants is a highly aggressive soft tissue tumour. Former opinions suggesting exenterative surgery and radiation to improve the dismal outcome in these young children, are outdated. Due to balanced therapies (topical tumourectomy, chemotherapy and radiation adjusted to tumour stage) cure of these sarcomas may be expected dependent on tumour stage, localisation and response to chemotherapy. The rate of complete remissions has increased in recent years. We report on an eighteen-month old girl with complete remission of tumour stage IIA who had been treated according to the CWS 91 protocol. Diagnosis and treatment were performed in March 1994 at the age of six months. We observed the patient in complete remission for 8 months (till September 1995).
Subject(s)
Rhabdomyosarcoma, Embryonal/congenital , Vaginal Neoplasms/congenital , Biomarkers, Tumor/analysis , Chemotherapy, Adjuvant , Combined Modality Therapy , Female , Follow-Up Studies , Humans , Infant , Neoplasm Staging , Rhabdomyosarcoma, Embryonal/drug therapy , Rhabdomyosarcoma, Embryonal/pathology , Rhabdomyosarcoma, Embryonal/surgery , Vagina/pathology , Vagina/surgery , Vaginal Neoplasms/drug therapy , Vaginal Neoplasms/pathology , Vaginal Neoplasms/surgeryABSTRACT
Se reporta el caso de una femenina, 2 meses de edad, que acudió a consulta por masa en abdomen derecho presente desde el nacimiento con aumento progresivo de tamaño hasta 11x8x5 cm. Luego de varios estudios radiográficos y urografía se estirpa el tumor. Se reporta histológicamente carcinoma vaginal
Subject(s)
Humans , Female , Infant , Vaginal Neoplasms/congenitalABSTRACT
In girls, endodermal sinus tumours are rare and malignant germinal tumours. They are highly lethal and it has previously been considered in cases with distant metastases at the time of diagnosis, that there is no satisfactory therapy. However, the rapid development during the last years of highly effective chemotherapeutic agents seems to have improved the survival rate. Already there are a few reports of surviving patients with metastatic disease. In our material of five girls with endodermal sinus tumour, one with metastatic disease has been treated according to a new protocol with combination therapy (cis-VAB). Four years after the operation she is alive and well without any sign of recurrence.
