The natural history of perforated foregut ulcers after repair by omental patching or primary closure.

BACKGROUND: The treatment of perforated foregut ulcers by omental patching (OP) or primary closure has mostly replaced vagotomy and pyloroplasty/antrectomy (VPA). We sought to determine the natural history and recurrence rate of ulceration in patients treated by omental patching or primary closure. STUDY DESIGN: An 11-year retrospective study. RESULTS: From 2004 through 2015, 94 patients had perforated foregut ulcers, 53 gastric, and 41 duodenal. 77 (82%) were treated by OP alone (study group) and 17 (18%) were treated with VPA (comparison group). All OP patients were discharged on PPIs, but only 86% took the drugs for a median of 22 months (1-192, SD 40). Endoscopy in the OP group showed recurrent ulcers in nine (12% recurrence rate) and gastritis in three (4%) This group also had three later recurrent perforations. Another recurrent ulcer hemorrhaged causing death (3% late mortality). Two other patients required non-emergent re-do ulcer operations for recurrent disease/symptoms (surgical re-intervention rate 4%). Total length of follow-up was median 44 months (1-192, SD 40) and was complete in 82 (87%). 18 (23%) patients in the OP group developed recurrent abdominal pain attributed to ulcer disease during follow-up, compared to 2 (12%) in the VPA group (p = 0.15). No patient in the VPA group had an endoscopic recurrence or re-intervention. CONCLUSION: Omental patching does not correct the underlying disease process which causes foregut perforation, and has a 12% endoscopically proven recurrent ulceration rate and a 23% incidence of recurrent symptoms within 44 months. Patients tend to stop taking PPIs after 22 months at which time their risk increases.

[The choice of resection volume by the combination of perforative duodenal ulcer with other complications of the ulcer disease].

Treatment results of 59 patients with the complicated ulcer disease were analyzed. Authors prove, that in cases of perforative duodenal ulcer, the operation should aim the treatment of all the complications. The use of 2/3 gaster resection in combination with Jadd pyloroplasty and trunk vagotomy led to the decrease of the lethality rate on 21%.

[Surgical treatment of hiatal hernias].

17 patients suffering from axial hiatal hernias with marked duodenogastroesophageal reflux underwent surgical treatment including selective proximal vagotomy combined with formation of closing cardia mechanism, enhancement in are flux function of pylorus, correction of duodenostasis. Specific postoperative complications and lethal outcomes were not observed. Increase of life quality was observed among patients in early and long-term postoperative periods in comparison with preoperative indices. Relapses or regurgitation disturbances were not observed either.

[Immunomodulation and systematic enzymotherapy during surgical treatment of the duodenal ulcers].

The aim of our investigation was to study the influence of the systematic enzymotherapy on the results of surgical treatment of patients with duodenal ulcers. The immunological investigation was conducted on 77 patients with duodenal ulcers. The obtained results reveal the changes of immunological indexes in patients with duodenal ulcers. The process of rehabilitation with immunomodulative and enzymatic therapy after surgical treatment is analyzed and described.

Laparoscopic highly selective vagotomy with nissen fundoplication: is there any role?

INTRODUCTION: Nissen fundoplication (NF) has not been a uniformly successful treatment for gastroesophageal reflux disease (GERD). Acid lowering procedures such as highly selective vagotomy (HSV) have not yet been fully evaluated as an adjunctive treatment. NFHSV was evaluated in GERD. MATERIALS AND METHODS: Between June 2003 and June 2005, 8 women with a history of 6 months of GERD unrelieved by medication, preprandial pain, peptic ulcer disease, or severe gastritis underwent laparoscopic NFHSV. They have been followed for a mean 12 months. Preoperative and postoperative Heartburn Severity scores (HSS) were obtained. RESULTS: Mean operative time was 110 minutes. There were no complications. One patient needed postoperative proton pump inhibitor, which was discontinued after smoking cessation 5 months after NFHSV. All 8 patients showed marked improvement in symptoms and HSS. CONCLUSIONS: This series lends credence to the notion that NFHSV was effective. Several studies need to be performed to demonstrate the full efficacy and safety of this approach.

Factibilidad de la vagotomía altamente selectiva con piroloplastia en la estenosis duodenal péptica / Feasibility of highly selective vagotomy with pyloroplasty in peptic duodenal stenosis

Se realizó un estudio prospectivo controlado, a simple ciega, en el Hospital Militar Central Dr Carlos J. Finlay durante un período de 16 años, con el objetivo de comprobar la factibilidad de la vagotomía altamente selectiva con piroloplastia en la estenosis duodenal péptica. Se comparó con la vagotomía altamente selectiva más duodenoplastia. La técnica de vagotomía altamente selectiva fue la modificación de Hill-Barker en ambos grupos. El estudio comprendió 64 pacientes, 51 hombres y 13 mujeres, con una edad promedio de 47 años. No hubo complicaciones intraoperatorias ni muertes. Se presentaron complicaciones posoperatorias tempranas en el 46,9 por ciento del grupo estudio y en 31,3 por ciento del grupo control, pero fueron leves y desaparecieron antes de los 3 primeros meses. Hubo 2 recidivas ulcerosas (6,3 por ciento) en el grupo estudio, no asociadas con la técnica. Los resultados clínicos fueron satisfactorios en el 96,9 por ciento del grupo control y en el 90,6 por ciento del grupo estudio, sin que se demostrara asociación con el proceder quirúrgico. Por tanto, la piloroplastia no anula los excelentes resultados de la vagotomía altamente selectiva.

A single-blind controlled prospective study was performed in Dr Carlos J. Finlay Central Military Hospital over o period of 16 years, to verify feasibility of a highly selective vagotomy with pyloroplasty in peptic duodenal stenosis. The highly selective vagotomy technique was of the Hill-Barker modification in both groups. Study included 64 patients, 51 males and 12 females aged as average 47. There wasn't intraoperative complications neither deaths. Early postoperative complications were present in 46.9 percent of study group, and in 31.3 percent of control group, but these were slights and disappeared before the three first months. There was two ulcerative relapses (6.3 percent) in study group, non-associated with technique. Clinical results were satisfactory in 96,9 percent of control group, and in 90.6 percent of study group, without association with surgical procedure. Thus, pyloroplasty don't invalidates excellent results of highly selective vagotomy.

Factibilidad de la vagotomía altamente selectiva con piroloplastia en la estenosis duodenal péptica / Feasibility of highly selective vagotomy with pyloroplasty in peptic duodenal stenosis

Se realizó un estudio prospectivo controlado, a simple ciega, en el Hospital Militar Central Dr Carlos J. Finlay durante un período de 16 años, con el objetivo de comprobar la factibilidad de la vagotomía altamente selectiva con piroloplastia en la estenosis duodenal péptica. Se comparó con la vagotomía altamente selectiva más duodenoplastia. La técnica de vagotomía altamente selectiva fue la modificación de Hill-Barker en ambos grupos. El estudio comprendió 64 pacientes, 51 hombres y 13 mujeres, con una edad promedio de 47 años. No hubo complicaciones intraoperatorias ni muertes. Se presentaron complicaciones posoperatorias tempranas en el 46,9 por ciento del grupo estudio y en 31,3 por ciento del grupo control, pero fueron leves y desaparecieron antes de los 3 primeros meses. Hubo 2 recidivas ulcerosas (6,3 por ciento) en el grupo estudio, no asociadas con la técnica. Los resultados clínicos fueron satisfactorios en el 96,9 por ciento del grupo control y en el 90,6 por ciento del grupo estudio, sin que se demostrara asociación con el proceder quirúrgico. Por tanto, la piloroplastia no anula los excelentes resultados de la vagotomía altamente selectiva(AU)

A single-blind controlled prospective study was performed in Dr Carlos J. Finlay Central Military Hospital over o period of 16 years, to verify feasibility of a highly selective vagotomy with pyloroplasty in peptic duodenal stenosis. The highly selective vagotomy technique was of the Hill-Barker modification in both groups. Study included 64 patients, 51 males and 12 females aged as average 47. There wasn't intraoperative complications neither deaths. Early postoperative complications were present in 46.9 percent of study group, and in 31.3 percent of control group, but these were slights and disappeared before the three first months. There was two ulcerative relapses (6.3 percent) in study group, non-associated with technique. Clinical results were satisfactory in 96,9 percent of control group, and in 90.6 percent of study group, without association with surgical procedure. Thus, pyloroplasty don't invalidates excellent results of highly selective vagotomy(AU)

[Selective proximal vagotomy with duodenoplasty for the treatment of ulcerous duodenal stenosis].

Short- and long-term results of isolated selective proximal vagotomy (SPV) performed at non-complicated duodenal ulcer and SPV with duodenoplastic and drainage surgeries at ulcerous pyloroduodenal stenosis were analyzed. Principles of choice of duodenoplastic and drainage surgeries are discussed. Six variants of duodenoplasty is used depending on anatomic characteristics and localization of stenosis. Advantage of duodenoplasty over drainage surgeries is demonstrated. It is concluded that SPV with duodenoplasty should be regarded as surgical method of choice at the treatment of ulcerous duodenal stenosis because of low rate of stomach and duodenum functional disorders at long-term period after surgery.

[Surgical treatment at combination of duodenal ulcers with reflux-esophagitis].

Selective proximal vagotomy (SPV) was performed at 352 patients with duodenal ulcer (DU), 213 of them had reflux-esophagitis (RE). SPV was performed with correcting cardia function operations at all the patients (including ones without RE). It is demonstrated that SPV at combination of RE with DU is safe but effective surgical method and permits to achieve complete recovery from both diseases. SPV is radical if indications are correct and surgical technical requirements are fulfilled.

[The application of the selective proximal vagotomy by the method of chemical denervation in treatment of patients of elderly and senile age suffering from the perforating pyloroduodenal ulcers].

The article presents the results of using the vagotomy of an acid-producing zone of a stomach by the method of chemical denervation. Subjects to the operation were 20 Wistar line male rats and 22 patients with perforating pyloroduodenal ulcers accompanied by cardio pathology. The simplicity, availability and low traumatism of the technique, in view of the low percent of a relapse of the pyloroduodenal ulcers, enable to recommend it for the treatment for the elderly patients with the heavy cardio pathology.

Vagotomía altamente selectiva convencional versus modificación de Hill-Barker en la úlcera péptica duodenal / Conventional highly selective vagotomy versus Hill-Baker´s modification in treating duodenal peptic ulcer

Se realizó un estudio prospectivo al azar a simple ciegas en el Hospital Militar Central "Dr Carlos J Finlay", durante un periodo de 20 años con el objetivo de comparar la vagotomía altamente selectiva convencional (VAS= 62 pacientes) y la modificación de Hill-Barker, vagotomía altamente selectiva anterior con troncular posterior (VASA + VTP= 69 pacientes) en el tratamiento de la úlcera péptica duodenal. El tiempo de seguimiento promedio fue de 10,8 años (rango de 2 a 20 años). No hubo complicaciones ni mortalidad operatorias. La VASA + VTP tuvo un tiempo quirúrgico significativamente menor que la VAS. Las complicaciones posoperatorias tempranas fueron en su mayoría ligeras y pasajeras en ambos grupos, pero las diarreas se asociaron significativamente con la VASA + VTP. Las recidivas se presentaron en el 11,3 por ciento de la VAS y en el 7,2 por ciento de la VASA + VTP. Los resultados clínicos fueron satisfactorios en el 87 por ciento de ambos grupos y no hubo asociación significativa en la comparación de ambas técnicas. Se demostró que la modificación de Hill-Barker es una alternativa por su rapidez y menor complejidad

Vagotomía altamente selectiva convencional versus modificación de Hill-Barker en la úlcera péptica duodenal / Conventional highly selective vagotomy versus Hill-Baker´s modification in treating duodenal peptic ulcer

Se realizó un estudio prospectivo al azar a simple ciegas en el Hospital Militar Central "Dr Carlos J Finlay", durante un periodo de 20 años con el objetivo de comparar la vagotomía altamente selectiva convencional (VAS= 62 pacientes) y la modificación de Hill-Barker, vagotomía altamente selectiva anterior con troncular posterior (VASA + VTP= 69 pacientes) en el tratamiento de la úlcera péptica duodenal. El tiempo de seguimiento promedio fue de 10,8 años (rango de 2 a 20 años). No hubo complicaciones ni mortalidad operatorias. La VASA + VTP tuvo un tiempo quirúrgico significativamente menor que la VAS. Las complicaciones posoperatorias tempranas fueron en su mayoría ligeras y pasajeras en ambos grupos, pero las diarreas se asociaron significativamente con la VASA + VTP. Las recidivas se presentaron en el 11,3 por ciento de la VAS y en el 7,2 por ciento de la VASA + VTP. Los resultados clínicos fueron satisfactorios en el 87 por ciento de ambos grupos y no hubo asociación significativa en la comparación de ambas técnicas. Se demostró que la modificación de Hill-Barker es una alternativa por su rapidez y menor complejidad(AU)

[Preventive surgical treatment of ulcer disease].

The state of gastric secretion in ulcer disease patients was investigated. Acidity was estimated by a computed analysis of 24 hour acidogastromonitoring with apparatus AG-24 MP "Gastroscan-24". The examination of 739 patients with chronic duodenal ulcers included 139 (18.8%) patients with exacerbation, 306 (41.1%) with bleeding, 185 (25%) after suturing the perforation, 59 (8%) with stenosis + 50 healthy subjects. A correlation was found between the efficiency of antisecretory drugs and "malignancy" of the course of ulcer disease. An aggressive type of the course of ulcer disease was determined in 178 patients with indications for operation, but the operations were not performed, in 102 out of them long-term results were followed up. The long-term results of operative treatment of uncomplicated ulcer were followed up in 181 (59%) patients.

[Surgical strategies in perforated of gastroduodenal ulcers combined with penetration and stenosis].

One hundred and twenty-six patients aged 14 to 88 years underwent surgery concerning perforative ulcer os stomach and duodenum. Forty-seven patients had symptoms of stenosis including 23 patients with penetration. It is demonstrated that vagotomy, incision of ulcer with duodenoplasty or pyloro-duodenoplasty permit to treat successfully perforative ulcers and to achieve good functional results in long-term period.

An audit of peptic ulcer surgery in Ibadan, Nigeria.

BACKGROUND: Several operations are useful for peptic ulcer surgery, these include Vagotomy and pyloroplasty, Vagotomy and antrectomy, Vagotomy and gastrojejunostomy, and Highly Selective Vagotomy to name a few. Utilising any of these procedures may be due to the operator's preference or more importantly the suitability of the operation to the individual patient. This study was carried out to see the surgical presentation of chronic peptic ulcer disease patients and the form of ulcer-surgery utilised in the University College Hospital Ibadan, Nigeria. STUDY DESIGN: A retrospective study of all the patients who were operated on for complications of peptic ulcer disease between January 1990 and December 2003 at the above-mentioned institution by studying the case-files, ward admission records and operation room registers of such patients. RESULT: There were 122 patients, 90 male and 32 female with a Male:Female ratio of 3:1. Pyloric stenosis accounted for 56.6% of patients followed by perforation (29.5%), bleeding (9.8%) and gastric ulcer (4.1%). Yearly presentations seem to be reducing. Truncal vagotomy and drainage was performed in 78.64% of the patients, simple closure for perforation in 29.5%, partial gastrectomy for 4.1% while the remaining 2.4% had underunning of a bleeding vessel. CONCLUSION: Pyloric stenosis (also called gastric outlet obstruction) is the most common surgical presentation of peptic ulcer disease in the University College Hospital Ibadan and Truncal Vagotomy and drainage is the most common surgical procedure performed for peptic ulcer.

Solid gastric emptying after highly selective vagotomy and pyloroplasty in patients with obstructing duodenal ulcer.

Before being superseded by medical management, highly selective vagotomy (HSV) without drainage was the procedure of choice for uncomplicated duodenal ulcer. It is also justified for complications, including perforation and bleeding in selected cases. This prospective study evaluated the effects of HSV plus drainage on solid gastric emptying in 20 patients with chronic duodenal ulcer and pyloric stenosis. Patients were treated with HSV plus pyloroplasty (Heineke-Mikulicz pyloroplasty in five patients, Finney pyloroplasty in six patients and Jaboulay gastroduodenostomy in nine patients) and underwent solid-phase gastric emptying scintigraphic studies pre-operatively and 2 months and 6 months post-operatively. Results were compared with those from 10 controls. No significant differences were observed between the different types of pyloroplasty, although emptying was slightly faster in the gastroduodenostomy group. Gastric emptying returned to normal by 6 months post-operatively. In conclusion, HSV plus pyloroplasty is effective and can be used for the relief of stenosis in selected cases of duodenal ulcer.

Vagotomía altamente selectiva en la úlcera duodenal complicada / Highly selective vagotomy in the complicated duodenal ulcer: 18 years of experience

Se realizó un estudio descriptivo-retrospectivo de los pacientes operados de úlcera duodenal complicada por la técnica de vagotomía altamente selectiva, en el Hospital Militar Central "Dr. Carlos J. Finlay", en el período comprendido entre 1984-2001. El objetivo principal fue presentar los resultados obtenidos en 2 variantes de esta técnica. Se operaron un total de 211 pacientes, de los cuales pudieron ser evaluados 192. El 31,2 por ciento (60 pacientes) tenían estenosis que necesitaron de un proceder de drenaje (duodenoplastia o piloroplastia). Se realizó la técnica de Hill-Barker en 116 pacientes y la de Johnston-Wilkinson en 76 pacientes. El tiempo quirúrgico promedio por operación fue de 134,5 min. Se presentaron complicaciones posoperatorias tempranas en el 36,7 por ciento de los pacientes a predominio de las diarreas. La mayoría de estas complicaciones cesaron en los 3 primeros meses del posoperatorio. Hubo recidivas en el 6,8 por ciento de los casos. Los resultados según evaluación clínica de Visick fueron satisfactorios en el 90,6 por ciento de los pacientes

Vagotomía altamente selectiva en la úlcera duodenal complicada / Highly selective vagotomy in the complicated duodenal ulcer: 18 years of experience

Se realizó un estudio descriptivo-retrospectivo de los pacientes operados de úlcera duodenal complicada por la técnica de vagotomía altamente selectiva, en el Hospital Militar Central "Dr. Carlos J. Finlay", en el período comprendido entre 1984-2001. El objetivo principal fue presentar los resultados obtenidos en 2 variantes de esta técnica. Se operaron un total de 211 pacientes, de los cuales pudieron ser evaluados 192. El 31,2 por ciento (60 pacientes) tenían estenosis que necesitaron de un proceder de drenaje (duodenoplastia o piloroplastia). Se realizó la técnica de Hill-Barker en 116 pacientes y la de Johnston-Wilkinson en 76 pacientes. El tiempo quirúrgico promedio por operación fue de 134,5 min. Se presentaron complicaciones posoperatorias tempranas en el 36,7 por ciento de los pacientes a predominio de las diarreas. La mayoría de estas complicaciones cesaron en los 3 primeros meses del posoperatorio. Hubo recidivas en el 6,8 por ciento de los casos. Los resultados según evaluación clínica de Visick fueron satisfactorios en el 90,6 por ciento de los pacientes(AU)