ABSTRACT
Aromatic derivatives of mevalonic acid (2-phenyl-3-methyl-3-hydroxy pentanic and 2,3-diphenyl-3-hydroxy pentanic acids) decreased the yield of unesterified fatty acids from adipose tissue by about 28-36 percent after subcutaneous administration into rats within one or two weeks and under conditions of incubation of the adipose tissue in vitro. Distinct decrease in the yield of glycerol was cause by 2,3-diphenyl-3-hydroxy pentanic acid (1 with 10-minus 3 = 5 with 10-minus 3 M) under conditions of lipolysis stimulated by adrenaline. Antilipolytic effect of the preparation was more pronounced than that of well-known hypolipidemic drug clofibrate (p-chlorophenhydroxy isobutyrate).
Subject(s)
Adipose Tissue/drug effects , Lipid Metabolism , Pentanoic Acids/analogs & derivatives , Valerates/analogs & derivatives , Adipose Tissue/metabolism , Animals , Clofibrate/pharmacology , Epididymis/drug effects , Epididymis/metabolism , Fatty Acids, Nonesterified/metabolism , Glycerol/metabolism , In Vitro Techniques , Injections, Subcutaneous , Male , Mevalonic Acid/pharmacology , Pentanoic Acids/pharmacology , Rats , Time FactorsABSTRACT
It was shown that oxygen at high pressure (OHP) induced epileptic seizures and pulmonary damages on mice. Dipropylacetate protected mice against nervous syndrome better than did dipropylacetamide. No significant pulmonary protection was observed with both drugs.
