1.
J Virol
; 86(17): 9504-9, 2012 Sep.
Article
in English
| MEDLINE
| ID: mdl-22696640
ABSTRACT
The restrictive properties of tripartite motif-containing 5 alpha (TRIM5α) from small ruminant species have not been explored. Here, we identify highly similar TRIM5α sequences in sheep and goats. Cells transduced with ovine TRIM5α effectively restricted the lentivirus visna/maedi virus DNA synthesis. Proteasome inhibition in cells transduced with ovine TRIM5α restored restricted viral DNA synthesis, suggesting a conserved mechanism of restriction. Identification of TRIM5α active molecular species may open new prophylactic strategies against lentiviral infections.
Subject(s)
Carrier Proteins/metabolism , Goat Diseases/immunology , Sheep Diseases/immunology , Visna-maedi virus/physiology , Visna/metabolism , Amino Acid Sequence , Animals , Carrier Proteins/chemistry , Carrier Proteins/genetics , Goat Diseases/genetics , Goat Diseases/metabolism , Goat Diseases/virology , Goats , Molecular Sequence Data , Phylogeny , Sequence Alignment , Sheep , Sheep Diseases/genetics , Sheep Diseases/metabolism , Sheep Diseases/virology , Visna/genetics , Visna/virology
2.
AIDS Res Hum Retroviruses
; 12(5): 421-3, 1996 Mar 20.
Article
in English
| MEDLINE
| ID: mdl-8882324
