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2.
Int J Gynecol Pathol ; 39(2): 115-118, 2020 Mar.
Article in English | MEDLINE | ID: mdl-30870250

ABSTRACT

A 37-yr-old patient previously diagnosed with human immunodeficiency virus initially presented with a genital lesion which upon histologic assessment was diagnosed as a pseudotumor associated with herpes simplex virus infection. The pseudotumor responded to initial treatment with Acyclovir, however, the lesion recurred 2 yr later and was diagnosed as plasma cell vulvitis. We discuss the clinical presentation, diagnostic work up and treatment options of such a rare lesion.


Subject(s)
Herpes Genitalis/complications , Plasma Cells/pathology , Vulvitis/etiology , Adult , Female , HIV Infections/complications , Humans , Hypertrophy/pathology , Vulvitis/pathology
3.
Int J Gynecol Pathol ; 39(5): 456-459, 2020 Sep.
Article in English | MEDLINE | ID: mdl-31433373

ABSTRACT

We report a case of vulvar silicone granulomas following injection of liquid silicone into the labia. The patient is a 51-yr-old female who presented with vulvar pain and enlarged, indurated labia majora. In the past, she had undergone bilateral labial cosmetic augmentation with a silicone-based filler injected directly into the labia and into the gluteal regions. This had been performed in a nonmedical setting. At surgery, oblong firm soft tissue masses were removed from both labia. Microscopically, the lesions demonstrated replacement of the subcutaneous adipose tissue by fibrous tissue containing innumerable round empty spaces of different sizes, either within or surrounded by macrophages and occasional foreign-body giant histiocytes. The clear vacuoles corresponded to silicone fluid which had been dissolved during tissue processing. There are only rare case reports of vulvar silicone granuloma in the literature, and these were due to migration of silicone to the vulva from distant sites. Our report details a case of vulvar silicone granuloma secondary to direct injection of liquid silicone material into the labia.


Subject(s)
Granuloma, Foreign-Body/diagnosis , Pain/diagnosis , Silicones/adverse effects , Vulvitis/diagnosis , Buttocks/pathology , Female , Granuloma, Foreign-Body/chemically induced , Granuloma, Foreign-Body/pathology , Humans , Immunohistochemistry , Middle Aged , Pain/chemically induced , Pain/pathology , Silicones/administration & dosage , Vulva/pathology , Vulvitis/chemically induced , Vulvitis/pathology
4.
Rev Chilena Infectol ; 36(5): 670-673, 2019 Oct.
Article in Spanish | MEDLINE | ID: mdl-31859811

ABSTRACT

Gnathostomiasis is an emerging disease in non-endemic countries. This zoonotic nematode requires aquatic freshwater environments to complete its life cycle where larvae get encrusted in fishes. Typically, the infection manifests as migratory subcutaneous lesion caused by the larvae trak, which produces an eosinophilic panniculitis. Here we describe a patient who presented a migratory lesion with no response to antimicrobial therapy, a careful travel and food history together with specific laboratory tests led to the correct diagnosis. Gnathostomiasis should be suspected in patients with migratory skin lesions who have consumed raw freshwater fish during travel to endemic countries in South America or Asia.


Subject(s)
Gnathostomiasis/pathology , Vulvitis/pathology , Vulvitis/parasitology , Adult , Animals , Diagnosis, Differential , Female , Gnathostoma , Gnathostomiasis/parasitology , Humans , Panniculitis/parasitology , Panniculitis/pathology , Travel-Related Illness , Vulvitis/diagnostic imaging
5.
J Low Genit Tract Dis ; 23(4): 287-289, 2019 Oct.
Article in English | MEDLINE | ID: mdl-31592977

ABSTRACT

OBJECTIVES: Group A streptococcus (GAS) vulvitis is rare, mainly reported in association with vaginitis. We examined the clinical features of GAS vulvitis in adults, the presence of other infected sites, and its association with dermatological conditions. MATERIALS AND METHODS: We retrospectively analyzed the medical files and photographs of adult patients with bacteriologically confirmed GAS vulvitis seen at 3 private clinics. Coexisting infected sites, associated dermatological conditions, and bacteriological results for the husbands of 3 patients were examined. RESULTS: Nineteen patients (mean age = 52.2 [range = 23-83] years) with vulvar GAS infections were identified. The vulvar symptoms consisted of pain (11 cases), pruritus (9), burning (4), and discharge (10). The predominant physical feature was bilateral erythema, mainly located on the labia minora and the inner aspect of the labia majora. This erythema was associated with oozing (3), edema (6), or fissures (6). Seventeen patients had an associated vaginal infection, which was asymptomatic in 7 cases; anal infections were present in 9 cases. The following 10 patients had associated dermatological conditions: psoriasis (6), lichen sclerosus (2), Paget disease (1), or vitiligo (1). Two (one each from the throat and penis) of the 3 bacteriological specimens taken from the 3 husbands were GAS positive. CONCLUSIONS: In most adult women, GAS vulvitis is associated with a vaginal infection that may be asymptomatic. A bilateral, oozing, and edematous or fissured erythema involving the vulvar or anovulvar area is suggestive of GAS vulvitis. The association with psoriasis and the benefits of screening household members and sexual partners deserves further attention.


Subject(s)
Psoriasis/complications , Streptococcal Infections/pathology , Streptococcus pyogenes/isolation & purification , Vulvitis/pathology , Adult , Aged , Aged, 80 and over , Female , Humans , Middle Aged , Retrospective Studies , Streptococcal Infections/microbiology , Vulvitis/microbiology , Young Adult
6.
Rev. chil. infectol ; 36(5): 670-673, oct. 2019. graf
Article in Spanish | LILACS | ID: biblio-1058095

ABSTRACT

Resumen La gnatostomiasis es una parasitosis emergente en países no endémicos. Este nematodo zoonótico requiere de agua dulce para su ciclo de vida, donde sus larvas se enquistan principalmente en peces. La migración subcutánea de las larvas produce habitualmente una paniculitis eosinofílica de rápido avance. Se describe un caso clínico de un paciente con una lesión migratoria, sin mejoría clínica con terapia antibacteriana. La búsqueda de factores de riesgo, sumado a la evolución y a los hallazgos de laboratorio hizo sospechar el diagnóstico. La gnatostomiasis debe ser sospechado en pacientes con lesiones de piel migratorias, que han consumido pescado crudo durante viajes a países endémicos en Sudamérica o Asia.


Gnathostomiasis is an emerging disease in non-endemic countries. This zoonotic nematode requires aquatic freshwater environments to complete its life cycle where larvae get encrusted in fishes. Typically, the infection manifests as migratory subcutaneous lesion caused by the larvae trak, which produces an eosinophilic panniculitis. Here we describe a patient who presented a migratory lesion with no response to antimicrobial therapy, a careful travel and food history together with specific laboratory tests led to the correct diagnosis. Gnathostomiasis should be suspected in patients with migratory skin lesions who have consumed raw freshwater fish during travel to endemic countries in South America or Asia.


Subject(s)
Humans , Animals , Female , Adult , Vulvitis/parasitology , Vulvitis/pathology , Gnathostomiasis/pathology , Vulvitis/diagnosis , Panniculitis/parasitology , Panniculitis/pathology , Diagnosis, Differential , Gnathostomiasis/parasitology , Travel-Related Illness , Gnathostoma
9.
Am J Dermatopathol ; 41(4): e39-e42, 2019 Apr.
Article in English | MEDLINE | ID: mdl-30252696

ABSTRACT

Mucinous metaplasia of the vulva (MMV) is a histopathologic finding that has been reported previously in only 3 patients and needs to be distinguished from vulvar extramammary Paget disease. We report 3 additional instances of MMV associated to Zoon vulvitis and vulvar lichen sclerosus et atrophicus. Histochemical and immunohistochemical studies were performed on biopsies from erythematous and erosive vulvar lesions of 3 women aged 64, 80 and 84 years, with features of Zoon vulvitis (2 cases) and lichen sclerosus et atrophicus (1 case). Mucin-containing epithelial cells were present on the uppermost layers of the squamous epithelium. On immunohistochemical study the metaplastic cells were positive for cytokeratin 7, epithelial membrane antigen and carcinoembryonic antigen, thus mimicking the phenotype of Paget disease. MMV is most likely related to chronic inflammation. Cytological and architectural features allow for distinction from Paget disease because the mucin-containing cells of mucinous metaplasia of the vulva lack atypia and are predominantly located on the most superficial layers of the surface epithelium.


Subject(s)
Lichen Sclerosus et Atrophicus/pathology , Metaplasia/pathology , Vulva/pathology , Vulvar Lichen Sclerosus/pathology , Vulvitis/pathology , Aged, 80 and over , Female , Humans , Middle Aged , Mucins/biosynthesis
10.
Ceska Gynekol ; 83(4): 286-290, 2018.
Article in English | MEDLINE | ID: mdl-30441960

ABSTRACT

OBJECTIVE: Description of finding out rare disease Zoon vullvitis. Desing: Case report and differential diagnosis. SETTING: Department of Obstetric and Gynecology, University Hospital Ostrava. CASE REPORT: Zoon vulvitis or plasma cell vulvitis (PCV) belongs to extremely rare and often misdiagnosed inflammatory disease of the vulva. Lesions may look like shiny, sharply bordered , erythematosus patches or macular lesions. Less than 50 cases have been reported. This article is devoted to clinical findings, differential diagnosis and treatment of PCV. We present one clinical case with typical clinical and histopathological manifestations. Risk of dysplasia exists and long-term follow-up is desirable.


Subject(s)
Vulvitis/diagnosis , Aged , Diagnosis, Differential , Female , Humans , Vulvitis/pathology
11.
Ann Dermatol Venereol ; 145(8-9): 492-499, 2018.
Article in French | MEDLINE | ID: mdl-29884528

ABSTRACT

BACKGROUND: Miescher's cheilitis, whether occurring alone or as part of Melkersson-Rosenthal syndrome, is a rare type of granulomatous inflammation of unknown cause with an even rarer genital equivalent. Herein, we describe a case of the latter condition developing over a 12-year period. PATIENTS AND METHODS: A 27-year-old woman presented episodes of unilateral vulvar oedema, which initially regressed but resulted over time in permanent vulvar and perineal tumefaction. Histology revealed epithelioid histocytic granulomas so mild that they were not noticed at the start of the disease. The oedema remained the sole sign for 12years and two gastrointestinal screening tests for Crohn's disease proved negative, diagnosis of the latter condition was ruled out. DISCUSSION: Miescher's granulomatous vulvitis requires differential diagnosis, essentially with regard to Crohn's disease. Our case illustrates the difficulty in diagnosing this rare disease as well as the uncertainties surrounding its physiopathology. Diagnosis rests upon repeated sampling and biopsies with repeated levels of sections in order to identify the characteristic perivascular granulomas, which may be very mild.


Subject(s)
Granuloma/pathology , Vulvitis/pathology , Adult , Epithelioid Cells/pathology , Female , Histiocytes/pathology , Humans
12.
An Bras Dermatol ; 92(5 Suppl 1): 166-168, 2017.
Article in English | MEDLINE | ID: mdl-29267481

ABSTRACT

Zoon vulvitis or vulvitis chronica plasmacellularis is a rare, chronic benign inflammation of the vulvar mucosa, diagnosed histologically, with variable therapeutic responses. It is important to be diagnosed because it mimics the presentation of other genital conditions, such as lichen planus and squamous cell carcinoma, which require specific treatment. We report a case of a female patient with three asymptomatic shallow ulcers on the labia minora. Laboratory tests ruled out infectious diseases and the biopsy was consistent with Zoon Vulvitis.


Subject(s)
Vulva/pathology , Vulvitis/pathology , Biopsy , Diagnosis, Differential , Female , Humans , Middle Aged , Plasma Cells/pathology
15.
An. bras. dermatol ; 92(5,supl.1): 166-168, 2017. graf
Article in English | LILACS | ID: biblio-887096

ABSTRACT

Abstract Zoon vulvitis or vulvitis chronica plasmacellularis is a rare, chronic benign inflammation of the vulvar mucosa, diagnosed histologically, with variable therapeutic responses. It is important to be diagnosed because it mimics the presentation of other genital conditions, such as lichen planus and squamous cell carcinoma, which require specific treatment. We report a case of a female patient with three asymptomatic shallow ulcers on the labia minora. Laboratory tests ruled out infectious diseases and the biopsy was consistent with Zoon Vulvitis.


Subject(s)
Humans , Female , Middle Aged , Vulva/pathology , Vulvitis/pathology , Plasma Cells/pathology , Biopsy , Diagnosis, Differential
16.
Rev. chil. obstet. ginecol ; 81(4): 321-323, ago. 2016. ilus
Article in Spanish | LILACS | ID: lil-795897

ABSTRACT

Se presenta un caso de una paciente de 84 años con vulvitis de Zoon. Se trata de una dermatosis vulvar de etiología incierta, muy poco frecuente, que ocasiona sintomatología inespecífica de prurito y escozor vulvar de larga evolución, acompañados de una o varias lesiones focales circunscritas y eritematosas de difícil diagnóstico clínico. Se insiste en la necesidad de realización de biopsia vulvar para obtención de un diagnóstico histológico de certeza. Se comentan las opciones terapéuticas actuales descritas en la literatura aunque no existe un tratamiento de elección.


An 84 year old female patient with Zoons vulvitis case is reported. It is a rare vulvar dermatosis of unknown etiology, with unspecific symptoms such as pruritus and vulvar stinging, both developed over a long period of time, accompanied with focal erythematous injuries. As a clinical diagnosis remains difficult, it is essential that a biopsy is obtained for accurate histological diagnosis. Despite different therapeutic options available, there is no consensus on a standardized treatment.


Subject(s)
Humans , Female , Aged, 80 and over , Vulvitis/diagnosis , Vulvitis/pathology , Vulvitis/drug therapy , Biopsy , Clobetasol/therapeutic use , Anti-Inflammatory Agents/therapeutic use
17.
Praxis (Bern 1994) ; 104(13): 689-93, 2015 Jun 17.
Article in German | MEDLINE | ID: mdl-26081381

ABSTRACT

Vuval pathologies manifested by allodynia and burning sensations can be due to infection, inflammatory dermatoses or other causes. Infective as well as certain inflammatory diseases, e.g. drug eruptions, allergic eczemas, irritative dermatitis/vulvitis, Behcet's Syndrome and pemphigus/pemphigoid usually respond well to conservative treatment. The category of inflammatory diseases also contains pathologies that in certain circumstances do require a surgical intervention, e.g. Lichen ruber planus/Lichen sclerosus, Condyloma, scars, premalignant lesions (VIN, genital M. Paget) and cancer. Vulodynia also can cause some stinging to the vulvar skin. The surgical aspects relating to the treatment of the benign and premalignant pathologies indicated above are mentioned in this mini-review.


Subject(s)
Precancerous Conditions/diagnosis , Precancerous Conditions/surgery , Vulvar Neoplasms/diagnosis , Vulvar Neoplasms/surgery , Vulvitis/diagnosis , Vulvitis/surgery , Vulvodynia/etiology , Vulvodynia/surgery , Diagnosis, Differential , Female , Humans , Precancerous Conditions/etiology , Precancerous Conditions/pathology , Vulva/pathology , Vulva/surgery , Vulvar Neoplasms/etiology , Vulvar Neoplasms/pathology , Vulvitis/etiology , Vulvitis/pathology , Vulvodynia/pathology
18.
Dermatology ; 230(2): 113-8, 2015.
Article in English | MEDLINE | ID: mdl-25633048

ABSTRACT

BACKGROUND: Studies assessing symptoms of plasma cell vulvitis (PCV) are lacking. OBJECTIVES: To assess the prevalence and severity of PCV-related symptoms and identify possible associations between patient characteristics, clinical features of PCV and treatments administered before a definitive diagnosis. METHODS: Thirty-six patients affected with PCV were included. Data were collected by direct interview and clinical examination. RESULTS: Thirty patients (83.3%) complained of symptoms: burning was the most frequent (80.6%) while dyspareunia was the severest. Of the symptomatic patients, 73.3% experienced severe symptoms. Severity of symptoms was not associated with age at onset and duration of PCV. Almost 70% of the patients had previously undergone treatments. CONCLUSIONS: Symptoms in PCV are frequent and more than often severe. Neither age at onset nor duration of the disease nor the extent of vulvar involvement were associated with symptom severity. Both the delay in diagnosis and the inappropriate previous treatments seem to indicate frequent misdiagnosis.


Subject(s)
Dyspareunia/etiology , Pain/etiology , Plasma Cells , Vulvitis/complications , Vulvitis/pathology , Adult , Age of Onset , Aged , Female , Humans , Middle Aged , Pain Measurement , Pruritus Vulvae/etiology , Retrospective Studies , Severity of Illness Index , Vulvitis/drug therapy , Young Adult
19.
Pediatr Dermatol ; 31(1): 111-3, 2014.
Article in English | MEDLINE | ID: mdl-24266857

ABSTRACT

Mastocytosis is a relatively common disorder characterized by mast cell collections in the skin and other organ systems. Affected children are more likely than adults to have limited cutaneous disease. We report two patients with localized vulvar mastocytosis in the absence of other cutaneous findings and review previous reports of vulvar involvement in cutaneous mastocytosis.


Subject(s)
Mastocytosis, Cutaneous/pathology , Vulva/pathology , Vulvitis/pathology , Biopsy , Child , Child, Preschool , Female , Humans
20.
J Int Assoc Provid AIDS Care ; 12(3): 159-61, 2013.
Article in English | MEDLINE | ID: mdl-23449712

ABSTRACT

Vulvitis circumscripta plasmacellularis or Zoon vulvitis is a rare benign condition that affects the vulva chronically. We herein report a case of Zoon vulvitis in a 52-year-old HIV-infected patient with an uncommon ulcerovegetating lesion diagnosed by histopathologic findings. The patient was treated with clobetasol propionate ointment and oral corticosteroid. Zoon vulvitisis is a rare vulvar disorder that offers a challenging diagnose and therapy. The patient was appropriately treated and remains disease free.


Subject(s)
HIV Infections/pathology , Plasma Cells/physiology , Skin Ulcer/pathology , Vulvitis/pathology , Diagnosis, Differential , Female , HIV Infections/complications , HIV Infections/therapy , Humans , Middle Aged , Skin Ulcer/etiology , Skin Ulcer/therapy , Vulvitis/etiology , Vulvitis/therapy
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