ABSTRACT
La incidencia de los quistes vaginales está estimada en un 1%; de estos, una parte los constituyen los quistes de origen embrionario, como es el caso del quiste del conducto de Gartner. Estos últimos suelen ser de pequeño tamaño y asintomáticos, aunque en algunas situaciones aumentan de tamaño y, por la localización, pueden dar lugar a sintomatología relacionada con patología del suelo pélvico. La importancia radica en un correcto diagnóstico diferencial, donde las pruebas complementarias de elección serán la ecografía transvaginal y, sobre todo, la resonancia magnética, la cual permitirá establecer las características del quiste, la localización y si existe o no asociación a anormalidades del sistema urinario. En este trabajo presentamos un caso de quiste del conducto de Gartner asociado a carcinoma invasivo de cérvix, diagnosticado en una mujer de 49 años que acudió a nuestra consulta presentando sintomatología relacionada con prolapso de órganos pélvicos, concretamente cistocele (AU)
The incidence of vaginal cysts is estimated to be 1%. Some of these cysts, such as Gartner's duct cyst, are of embryological origin. These cysts are usually small and asymptomatic but they can sometimes grow and, due to their location, produce symptoms related to pelvic floor disease. A correct differential diagnosis is essential, in which the main complementary tests are transvaginal ultrasound and especially magnetic resonance imaging, which will establish the features and location of the cyst as well as any anomalies of the urinary system. We report a case of Gartner's duct cyst associated with invasive cervical carcinoma in a 49-year-old woman who presented with symptoms similar to pelvic organ prolapse, specifically cystocele (AU)
Subject(s)
Humans , Female , Middle Aged , Wolffian Ducts/anatomy & histology , Wolffian Ducts/pathology , Wolffian Ducts/surgery , Uterine Cervical Neoplasms/complications , Uterine Cervical Neoplasms/diagnosis , Uterine Cervical Neoplasms/surgery , Carcinoma/complications , Wolffian Ducts/physiopathology , Wolffian Ducts , Magnetic Resonance Imaging , Quality of LifeABSTRACT
For over a half century, the ACI (August x Copenhagen) rat has been a primary model for studying renal agenesis and ipsilateral hypoplasia (IHP) of the Wolffian-derived structures (WDS). Because the ACI rat is also used as a model for prostate research, it is important to examine the relationship of IHP and urogenital sinus (UGS) development. The prostate is dependent on androgens for proper growth and differentiation. Alteration in androgen production and/or delivery to the UGS has the potential to perturbate normal development. In this study, we investigate whether the ipsilateral loss of the WDS is associated with altered prostate development. Digital images of serial-sectioned fetal ACI rat UGS were used to create three-dimensional (3-D) surface-rendered models of the developing prostate, seminal vesicle, vas deferens, and utricle on gestational day 21. The number and volume of prostate ducts developing from the UGS were calculated from the 3-D model data. Animals exhibiting IHP had a significant decrease in total fetal prostate volume (40%; P < 0.005) with significant regional specific differences when compared with normal male ACI rats. Anatomical and histological differences in the utricle, abnormal histology of the ipsilateral testes, and a truncation of the ipsilateral Wolffian ductal mesenchyme were also seen in the animals with IHP. Additional research is needed to further understand the mechanisms and consequences of IHP on prostate growth and development. Alterations to normal prenatal development of the male accessory sex organs can have important consequences for the growth and morphology of the adult gland.
Subject(s)
Androgens/deficiency , Prostate/abnormalities , Prostate/physiopathology , Urogenital Abnormalities/physiopathology , Wolffian Ducts/abnormalities , Wolffian Ducts/physiopathology , Androgens/metabolism , Animals , Disease Models, Animal , Imaging, Three-Dimensional/methods , Male , Mesoderm/abnormalities , Mesoderm/metabolism , Mesoderm/physiopathology , Models, Anatomic , Organogenesis/physiology , Prostate/metabolism , Rats , Rats, Inbred ACI , Sex Differentiation/physiology , Testis/abnormalities , Testis/metabolism , Testis/physiopathology , Urogenital Abnormalities/etiology , Urogenital Abnormalities/metabolism , Wolffian Ducts/metabolismABSTRACT
Congenital abnormalities of the genital or urinary tract are not uncommon and often occur together. This article discusses a unique case in which a functioning mesonephric remnant was found.
