1.
Pneumologie
; 70(S 02): S169-S173, 2016 Dec.
Article
in German
| MEDLINE
| ID: mdl-27926963
Subject(s)
Biomedical Research/history , Electrophoresis/history , Pulmonary Emphysema/history , Pulmonary Medicine/history , alpha 1-Antitrypsin Deficiency/history , alpha 1-Antitrypsin/history , History, 20th Century , Humans , Molecular Diagnostic Techniques , Pulmonary Emphysema/diagnosis , Sweden , alpha 1-Antitrypsin Deficiency/diagnosis
2.
COPD
; 10 Suppl 1: 3-8, 2013 Mar.
Article
in English
| MEDLINE
| ID: mdl-23527532
3.
Chest
; 95(1): 181-9, 1989 Jan.
Article
in English
| MEDLINE
| ID: mdl-2642407
Subject(s)
alpha 1-Antitrypsin Deficiency , Granulocytes/enzymology , History, 20th Century , Homozygote , Humans , Lung/diagnostic imaging , Lung/pathology , Pancreatic Elastase/metabolism , Pedigree , Phenotype , Pulmonary Emphysema/enzymology , Pulmonary Emphysema/etiology , Pulmonary Emphysema/genetics , Radiography , alpha 1-Antitrypsin/genetics , alpha 1-Antitrypsin/history
4.
Schweiz Med Wochenschr
; 114(25): 893-4, 1984 Jun 23.
Article
in English
| MEDLINE
| ID: mdl-6379866
ABSTRACT
A short review is given on the discovery of the alpha 1-antitrypsin deficiency, a hereditary metabolic defect, in 1963, its biochemical identification, the recognition of its typical clinical manifestations and effects on lung physiology. Several genetic variants are mentioned. The gradual development of the concept of proteolytic digestion of lung elastin by excess of leucocyte elastase as a basic phenomenon in the pathogenesis of emphysema is discussed in some detail.
