Subject(s)
DNA, Bacterial/history , Escherichia coli/drug effects , Gene Expression/drug effects , Mitomycins/pharmacology , DNA Repair , DNA, Bacterial/genetics , Enzyme Induction/drug effects , Enzyme Induction/radiation effects , Escherichia coli/genetics , History, 20th Century , Lac Operon , Recombination, Genetic , Ultraviolet Rays , beta-Galactosidase/genetics , beta-Galactosidase/historySubject(s)
Lac Operon , Acetyltransferases/genetics , Acetyltransferases/history , Escherichia coli/genetics , Escherichia coli Proteins/genetics , Escherichia coli Proteins/history , History, 20th Century , Membrane Transport Proteins/genetics , Membrane Transport Proteins/history , Translations , beta-Galactosidase/genetics , beta-Galactosidase/historyABSTRACT
This is a personal reminiscence of what happened in one year, nearly 50 years ago, when I spent a sabbatical year at The Pasteur Institute in Paris. The year was fascinating, for I met and worked with Jacques Monod and Francois Jacob, a collaboration that culminated in the famous PaJaMa experiment.
Subject(s)
Biochemistry/history , Feedback , History, 20th Century , Paris , United States , beta-Galactosidase/genetics , beta-Galactosidase/history , beta-Galactosidase/metabolismABSTRACT
The enzyme beta-galactosidase was first mentioned in the literature by Beijerinck exactly a hundred years ago. The Department of Microbiology and Enzymology of the Delft University of Technology keeps the memory of Beijerinck, its first professor, alive by maintaining a 'Beijerinck-room' in the attic of the building. In addition to manuscripts and laboratory notebooks, this room contains some of his chemicals and biological preparations, and it was here that we recently found a 90-year old lactase preparation. Even after storage under suboptimal conditions, the preparation still exhibited measurable enzyme activities.
