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2.
J Clin Microbiol ; 15(6): 1167-8, 1982 Jun.
Article in English | MEDLINE | ID: mdl-6980897

ABSTRACT

The chromogenic cephalosporin nitrocefin was used to detect the presence of beta-lactamase in cerebrospinal fluid of patients suffering from ampicillin-resistant Haemophilus influenzae meningitis. Five samples of spinal fluid containing ampicillin-resistant isolates were studied, and all had beta-lactamase activity. When samples of spinal fluid containing 33 ampicillin-sensitive isolates and 234 sterile specimens were tested, no beta-lactamase activity was detected.


Subject(s)
Ampicillin/pharmacology , Haemophilus influenzae/enzymology , beta-Lactamases/cerebrospinal fluid , Cerebrospinal Fluid/microbiology , Haemophilus influenzae/drug effects , Humans , Methods , Penicillin Resistance
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