Search | VHL Regional Portal

Effects of Prolyl-Glycyl-Proline (PGP) peptide on disorders in rat mesenteric lymphatic vessel function induced by injection of substance 48/80.

Umarova, B A; Bondarenko, N S; Lelekova, T V; Kopylova, G N; Samonina, G E.

Bull Exp Biol Med ; 152(4): 447-50, 2012 Feb.

Article in English, Russian | MEDLINE | ID: mdl-22803108

ABSTRACT

Injection of substance 48/80 to rats led to dysfunction of mesenteric lymphatic microvessels, in particular inhibition of their contractility and modification of their reaction to norepinephrine. Injection of PGP peptide before and after substance 48/80 alleviated these disorders. The results indicated the possibility of peptide correction of lymphatic vessel dysfunction.

Subject(s)

Lymphatic Vessels/drug effects , Norepinephrine/administration & dosage , Oligopeptides/therapeutic use , Proline/analogs & derivatives , p-Methoxy-N-methylphenethylamine/analogs & derivatives , p-Methoxy-N-methylphenethylamine/administration & dosage , Animals , Injections, Intramuscular , Lymphatic Vessels/physiopathology , Male , Mesentery/drug effects , Proline/therapeutic use , Rats

A cross species study of polyamine induced histamine release.

Hong, S M; Read, G W.

Proc West Pharmacol Soc ; 24: 367-9, 1981.

Article in English | MEDLINE | ID: mdl-6166951

Subject(s)

Histamine Release/drug effects , Polyamines/pharmacology , Animals , Blood Pressure/drug effects , Cats , Cricetinae , Herpestidae , In Vitro Techniques , Mast Cells/metabolism , Rabbits , Rats , Species Specificity , p-Methoxy-N-methylphenethylamine/analogs & derivatives , p-Methoxy-N-methylphenethylamine/pharmacology

ABSTRACT

Subject(s)

Subject(s)

SEND TO:

SELECTION OF CITATIONS

SEARCH DETAIL