1.
Nat Med
; 12(8): 881-2, 2006 Aug.
Article
in English
| MEDLINE
| ID: mdl-16892027
Subject(s)
Antineoplastic Agents/therapeutic use , Drug Delivery Systems/methods , Neoplasms/therapy , Antibodies, Monoclonal/therapeutic use , Benzamides , Enzyme Inhibitors/adverse effects , Enzyme Inhibitors/therapeutic use , Heart Failure/chemically induced , Heart Failure/physiopathology , Humans , Imatinib Mesylate , Leukemia, Myelogenous, Chronic, BCR-ABL Positive/therapy , Models, Biological , Neoplasms/drug therapy , Piperazines/therapeutic use , Piperazines/toxicity , Pyrimidines/therapeutic use , Pyrimidines/toxicity , Ventricular Dysfunction, Left/chemically induced , Ventricular Dysfunction, Left/physiopathology , src-Family Kinases/adverse effects , src-Family Kinases/antagonists & inhibitors
2.
Drugs
; 59(3): 435-76, 2000 Mar.
Article
in English
| MEDLINE
| ID: mdl-10776829
ABSTRACT
The most essential kinases involved in cell membrane receptor activation, signal transduction and cell cycle control or programmed cell death and their interconnections are reviewed. In tumours, the genes of many of those kinases are mutated or amplified or the proteins are overexpressed. The use of key kinases offers the possibility to screen in vitro for synthetic small molecule kinase inhibitors. In view of the many interconnections of cellular kinases, their role in preventing or inducing programmed cell death and the possibility that a considerable number of signal transducing proteins are still unknown, cellular test systems are recommended in which the respective key kinase or one of its main partner molecules are overexpressed.