RESUMEN
Cerebellar abiotrophy (CA) is a degenerative disorder of the central nervous system (CNS) that has been reported in humans and animals. In cattle, CA had been reported in Bos taurus taurus and crossbreed cattle. CA is characterized by degeneration and loss of Purkinje cells and decrease in the population of granule cells. The pathogenesis of this process is unknown, but it is believed that there is an autosomal recessive heritable factor involved. A 15-month-old Nelore ox (Bos taurus indicus) was sent to a slaughterhouse, where it presented cerebellar ataxia, symmetrical hypermetria, spasticity, ptyalism, and incoordination. There were no macroscopic changes. CNS samples were negative for BSE, rabies, and other infectious pathogens. Microscopically, there was atrophy of the molecular, granular, and Purkinje cell layers of the cerebellar cortex, and a marked and diffuse loss of the Purkinje cells. No other microscopic lesions were observed in CNS. These findings were consistent with cerebellar abiotrophy. To the best of our knowledge, no cases of CA have ever been reported in Bos taurus indicus. Therefore, the present case of CA in Nelore is the first report of the disease in Zebu cattle.
RESUMEN
Protothecosis is a rare disease caused by achlorophyllic algae of the genus Prototheca. This case involved a 5 year-old intact female Cocker Spaniel, with a history of mild and persistent diarrhea that was not responsive to treatment. Clinical signs progressed to watery and bloody diarrhea followed by development of ocular signs, including complete and bilateral retinal displacement, glaucoma, synechia, and blindness. At necropsy, lesions observed consisted of necro-hemorrhagic enteritis, and multiple white nodular lesions in the heart, pancreas, kidneys, and thyroid gland. Microscopically, the nodular lesions were characterized by a chronic histiocytic inflammatory infiltrate associated with a severe accumulation of organisms with morphology and histochemical features compatible with Prototheca sp.