RESUMEN
The present study shows the effectiveness of using polyunsaturated fatty acids in pregnant rats in order to prevent behavioral alterations in neonatal rats caused by the action of the pathogenic peptide factors of blood serum with perinatal damage of the central nervous system.
Asunto(s)
Conducta Animal/efectos de los fármacos , Ácidos Grasos Insaturados/farmacología , Trastornos Neurológicos de la Marcha/prevención & control , Preeclampsia , Suero , Animales , Animales Recién Nacidos , Femenino , Trastornos Neurológicos de la Marcha/inducido químicamente , Trastornos Neurológicos de la Marcha/congénito , Humanos , Masculino , Embarazo , RatasRESUMEN
Embryotoxic effect of serotonin in direct (intra-amniotic administration) and indirect (subcutaneous administration) treatment was studied. In both cases serotonin causes embryo death and different abnormalities in development in small number of embryos. Mechanism of serotonin embryotoxic effect is under discussion.
Asunto(s)
Creatinina/toxicidad , Embrión de Mamíferos/efectos de los fármacos , Serotonina/toxicidad , Anomalías Inducidas por Medicamentos/etiología , Anomalías Inducidas por Medicamentos/patología , Amnios , Animales , Creatinina/administración & dosificación , Relación Dosis-Respuesta a Droga , Combinación de Medicamentos , Pérdida del Embrión/inducido químicamente , Pérdida del Embrión/patología , Femenino , Edad Gestacional , Inyecciones , Inyecciones Subcutáneas , Embarazo , Ratas , Serotonina/administración & dosificaciónRESUMEN
Pregnant rats (day 14 of gestation) received intraamniotic injections of newborn human serum. Transfer factors (TF) present in injected serum produced significant embryotoxic and teratogenic effects, as well as changes in coordination of motor activity (EMG) in newborn rats. The extent of embryological disturbances and the motor activity of 33- to 34-day old recipient rats depend on TF concentration (at serum dilution 1:2) and on the state of infant's motor functions ("normal" group and "risk" group). The results obtained allow to objectively determine the pathogenic effect of serum TF on embryotoxicity and formation of motor coordination in the donor infant.
Asunto(s)
Embrión de Mamíferos/efectos de los fármacos , Efectos Tardíos de la Exposición Prenatal , Factor de Transferencia/sangre , Factor de Transferencia/toxicidad , Anomalías Inducidas por Medicamentos/etiología , Amnios , Animales , Animales Recién Nacidos , Electromiografía/efectos de los fármacos , Pérdida del Embrión/inducido químicamente , Femenino , Humanos , Recién Nacido , Inyecciones , Embarazo , Ratas , Factor de Transferencia/administración & dosificaciónRESUMEN
Breach of locomotor functions and spatially oriented behaviour of rats' cubs after intraamniotic administration of the blood serum of children was shown to depend on the ontogenetic maturity and motor disturbances of donors. Injections were carried out on 14-th day of rats pregnancy.
Asunto(s)
Locomoción/fisiología , Conducta Espacial , Animales , Parálisis Cerebral/sangre , Niño , Femenino , Humanos , Recién Nacido , Discapacidad Intelectual/sangre , Locomoción/efectos de los fármacos , Embarazo , Efectos Tardíos de la Exposición Prenatal , Desempeño Psicomotor/efectos de los fármacos , Desempeño Psicomotor/fisiología , Ratas , Factor de Transferencia/farmacologíaRESUMEN
Morphological quantitative and qualitative analysis of the pyramidal neurones in the motor cortex of rat puppies after administration of the blood serum from human donors with central motor disorders reveals the dependence of the quality and quantity of neurones from the effect of corresponding blood sera. Pathologic blood serum decreases the number and induces degradation of dendritic organization of the pyramidal neurones. The effect of the blood sera on quantitative and qualitative properties of the pyramidal neurones in rat puppies depends on the age of donor infants with central motor disorders. Blood serum from newborn babies with motor dysfunctions significantly decreases the number of labeled pyramidal neurones and results in degradation of dendritic organization, whereas sera from 11-13-year infants only insignificantly affect these characteristics.