Digital twin and fuzzy framework for supply chain sustainability risk assessment and management in supplier selection.

Risks in the supply chain can damage many companies and organizations due to sustainability risk factors. This study evaluates the supply chain risk assessment and management and then selects the best supplier in a gas company in Egypt. A comprehensive methodology can use the experts' opinions who use the linguistic variables in the spherical fuzzy numbers (SFNs) to evaluate the criteria and suppliers in this study based on their views. Selecting the best supplier is a complex task due to various criteria related to supply chain risk assessment, such as supply risks, environmental risks, financial risks, regularity risks, political risk, ethical risks, and technology risks and their sub-criteria. This study suggested a new combined model with multi-criteria decision-making (MCDM) under a spherical fuzzy set (SFS) environment to overcome uncertainty and incomplete data in the assessment process. The MCDM methodology has two methods: the Entropy and COmbinative Distance-based Assessment (CODAS) methods. The SFS-Entropy is used to compute supply chain risk assessment and management criteria weights. The SFS-CODAS method is used to rank the supplier. The main results show that supply risks have the highest importance, followed by financial and environmental risks, and ethical risks have the lowest risk importance. The criteria weights were changed under sensitivity analysis to show the stability and validation of the results obtained from the suggested methodology. The comparative analysis is implemented with other MCDM methods named TOPSIS, VIKOR, MARCOS, COPRAS, WASPAS, and MULTIMOORA methods under the SFS environment. This study can help managers and organizations select the best supplier with the lowest sustainability risks.

Extension of simple multi-attribute rating technique in uncertainty environment for 5G industry evaluation: Egyptian new administrative capital as a case study.

As is well-known, multicriteria decision-making (MCDM) approaches can aid decision-makers in identifying the optimal alternative based on predetermined criteria. However, it is a big challenge to apply this approach in complex applications such as 5th generation (5G) industry assessment because criteria are challenging and trade-offs between them are hard. Also, assessment of the 5G industry involve strong uncertainty. So, this study is the first to evaluate the 5G industry using a new neutrosophic simple multi-attribute rating technique (N-SMART). Since neutrosophic set considers truth-degree, indeterminacy-degree, and falsity-degree, it is a more accurate instrument for evaluating uncertainty. The 5G assessment issue exemplifies the validity and great performance of our proposed method as: (1) its ability to deal with uncertainty phenomena; (2) its simplicity; and (3) its enhanced capacity to discern alternatives. Also, by considering the 5G service provided in the Egyptian New Administrative capital as a case study, the results showed that Ericsson 5G is the best choice and Nokia 5G is the worst choice.

Novel hybrid kepler optimization algorithm for parameter estimation of photovoltaic modules.

The parameter identification problem of photovoltaic (PV) models is classified as a complex nonlinear optimization problem that cannot be accurately solved by traditional techniques. Therefore, metaheuristic algorithms have been recently used to solve this problem due to their potential to approximate the optimal solution for several complicated optimization problems. Despite that, the existing metaheuristic algorithms still suffer from sluggish convergence rates and stagnation in local optima when applied to tackle this problem. Therefore, this study presents a new parameter estimation technique, namely HKOA, based on integrating the recently published Kepler optimization algorithm (KOA) with the ranking-based update and exploitation improvement mechanisms to accurately estimate the unknown parameters of the third-, single-, and double-diode models. The former mechanism aims at promoting the KOA's exploration operator to diminish getting stuck in local optima, while the latter mechanism is used to strengthen its exploitation operator to faster converge to the approximate solution. Both KOA and HKOA are validated using the RTC France solar cell and five PV modules, including Photowatt-PWP201, Ultra 85-P, Ultra 85-P, STP6-120/36, and STM6-40/36, to show their efficiency and stability. In addition, they are extensively compared to several optimization techniques to show their effectiveness. According to the experimental findings, HKOA is a strong alternative method for estimating the unknown parameters of PV models because it can yield substantially different and superior findings for the third-, single-, and double-diode models.

MIC-Net: A deep network for cross-site segmentation of COVID-19 infection in the fog-assisted IoMT.

The automatic segmentation of COVID-19 pneumonia from a computerized tomography (CT) scan has become a major interest for scholars in developing a powerful diagnostic framework in the Internet of Medical Things (IoMT). Federated deep learning (FDL) is considered a promising approach for efficient and cooperative training from multi-institutional image data. However, the nonindependent and identically distributed (Non-IID) data from health care remain a remarkable challenge, limiting the applicability of FDL in the real world. The variability in features incurred by different scanning protocols, scanners, or acquisition parameters produces the learning drift phenomena during the training, which impairs both the training speed and segmentation performance of the model. This paper proposes a novel FDL approach for reliable and efficient multi-institutional COVID-19 segmentation, called MIC-Net. MIC-Net consists of three main building modules: the down-sampler, context enrichment (CE) module, and up-sampler. The down-sampler was designed to effectively learn both local and global representations from input CT scans by combining the advantages of lightweight convolutional and attention modules. The contextual enrichment (CE) module is introduced to enable the network to capture the contextual representation that can be later exploited to enrich the semantic knowledge of the up-sampler through skip connections. To further tackle the inter-site heterogeneity within the model, the approach uses an adaptive and switchable normalization (ASN) to adaptively choose the best normalization strategy according to the underlying data. A novel federated periodic selection protocol (FED-PCS) is proposed to fairly select the training participants according to their resource state, data quality, and loss of a local model. The results of an experimental evaluation of MIC-Net on three publicly available data sets show its robust performance, with an average dice score of 88.90% and an average surface dice of 87.53%.

MT-nCov-Net: A Multitask Deep-Learning Framework for Efficient Diagnosis of COVID-19 Using Tomography Scans.

The localization and segmentation of the novel coronavirus disease of 2019 (COVID-19) lesions from computerized tomography (CT) scans are of great significance for developing an efficient computer-aided diagnosis system. Deep learning (DL) has emerged as one of the best choices for developing such a system. However, several challenges limit the efficiency of DL approaches, including data heterogeneity, considerable variety in the shape and size of the lesions, lesion imbalance, and scarce annotation. In this article, a novel multitask regression network for segmenting COVID-19 lesions is proposed to address these challenges. We name the framework MT-nCov-Net. We formulate lesion segmentation as a multitask shape regression problem that enables partaking the poor-, intermediate-, and high-quality features between various tasks. A multiscale feature learning (MFL) module is presented to capture the multiscale semantic information, which helps to efficiently learn small and large lesion features while reducing the semantic gap between different scale representations. In addition, a fine-grained lesion localization (FLL) module is introduced to detect infection lesions using an adaptive dual-attention mechanism. The generated location map and the fused multiscale representations are subsequently passed to the lesion regression (LR) module to segment the infection lesions. MT-nCov-Net enables learning complete lesion properties to accurately segment the COVID-19 lesion by regressing its shape. MT-nCov-Net is experimentally evaluated on two public multisource datasets, and the overall performance validates its superiority over the current cutting-edge approaches and demonstrates its effectiveness in tackling the problems facing the diagnosis of COVID-19.

Intelligent model for contemporary supply chain barriers in manufacturing sectors under the impact of the COVID-19 pandemic.

The COVID-19 pandemic has cast a shadow on the global economy. Since the beginning of 2020, the pandemic has contributed significantly to the global recession. In addition to the health damages of the pandemic, the economic impacts are also severe. The consequences of such effects have pushed global supply chains toward their breaking point. Industries have faced multiple obstacles, threatening the fragile flow of raw materials, spare parts, and consumer goods. Previous studies showed that supply chain barriers have multi-faceted impacts on industries and supply chains, which demand appropriate measures. In this regard, seven major barriers that directly impact industries have been identified to determine which industry is most affected by the COVID-19 pandemic. This paper utilized a hybrid multi-criteria decision-making (MCDM) approach under a neutrosophic environment using trapezoidal neutrosophic numbers to rank those barriers. The Analytical Network Process (ANP) quantifies the effects and considers the interrelationships between the determined barriers (criteria) involved in decision-making. Subsequently, the Measurement Alternatives and Ranking according to the COmpromise Solution (MARCOS) method was adopted to rank six industries according to the impact of those barriers. Results show that the lack of inventory is the largest barrier to influencing industries, followed by the lack of manpower. Sensitivity analysis is performed to detect the change in the rank of industries according to the change in the relative importance of the barriers.

New multi-criteria decision-making technique based on neutrosophic axiomatic design.

There are several multicriteria decision-making (MCDM) approaches presented in the literature with their characteristics. Although traditional MCDM approaches are considered a proper implementation to select the best alternative from available types, they failed to consider uncertainty which is quite high and desires to be thoughtfully measured in the selection process. This research focuses on extending MCDM in the neutrosophic environment using axiomatic design (AD) as a novel contribution to selecting appropriate Computed Tomography (CT) devices. We present a new linguistic scale for evaluating criteria and alternatives based on single-valued triangular neutrosophic numbers (SVTrN). The proposed approach is superior to other existing approaches due to its simplicity and ability to simulate natural human thinking via considering truth, indeterminacy, and falsity degrees. Then, applying it will increase the value of imaging for medical decision-making and decrease needless costs. So, this study can be valuable to researchers by helping them consider the appropriate medical imaging system selection problem theoretically under uncertainty, and for governments and organizations to design better satisfying medical imaging evaluation systems.

An Optimization Model for Appraising Intrusion-Detection Systems for Network Security Communications: Applications, Challenges, and Solutions.

Cyber-attacks are getting increasingly complex, and as a result, the functional concerns of intrusion-detection systems (IDSs) are becoming increasingly difficult to resolve. The credibility of security services, such as privacy preservation, authenticity, and accessibility, may be jeopardized if breaches are not detected. Different organizations currently utilize a variety of tactics, strategies, and technology to protect the systems' credibility in order to combat these dangers. Safeguarding approaches include establishing rules and procedures, developing user awareness, deploying firewall and verification systems, regulating system access, and forming computer-issue management groups. The effectiveness of intrusion-detection systems is not sufficiently recognized. IDS is used in businesses to examine possibly harmful tendencies occurring in technological environments. Determining an effective IDS is a complex task for organizations that require consideration of many key criteria and their sub-aspects. To deal with these multiple and interrelated criteria and their sub-aspects, a multi-criteria decision-making (MCMD) approach was applied. These criteria and their sub-aspects can also include some ambiguity and uncertainty, and thus they were treated using q-rung orthopair fuzzy sets (q-ROFS) and q-rung orthopair fuzzy numbers (q-ROFNs). Additionally, the problem of combining expert and specialist opinions was dealt with using the q-rung orthopair fuzzy weighted geometric (q-ROFWG). Initially, the entropy method was applied to assess the priorities of the key criteria and their sub-aspects. Then, the combined compromised solution (CoCoSo) method was applied to evaluate six IDSs according to their effectiveness and reliability. Afterward, comparative and sensitivity analyses were performed to confirm the stability, reliability, and performance of the proposed approach. The findings indicate that most of the IDSs appear to be systems with high potential. According to the results, Suricata is the best IDS that relies on multi-threading performance.

New extension of ordinal priority approach for multiple attribute decision-making problems: design and analysis.

The selection and assessment process of appropriate robots became a more complex and complicated task due to various available alternatives and conflicting attributes which must take into consideration. Also, uncertainty which exists usually in the selection process is an unavoidable component that needs to be thoughtfully measured and traditional multi-attribute decision-making approaches failed to deal precisely with it. Since almost all decisions originate from subjective ordinal preferences, handling uncertainty using linguistic variables is also not enough. Thus, the objective of the current study is to present a new extended ordinal priority approach in the neutrosophic environment for the first time to select an appropriate robot. Since neutrosophic is one of the most effective and accommodating tools for handling uncertainty, thus, this method goes to transform linguistic information into triangular neutrosophic numbers using a new presented scale. This scale was used to determine the importance degree of attributes and alternatives regarding experts' opinions. Also, the score function of the triangular neutrosophic number is used for prioritizing attributes and alternatives. The experts in our proposed method have the same degree of importance, since each expert is a person with special skills and knowledge representing mastery of a particular subject. To measure the applicability and efficiency of the proposed approach, an experimental case study has been established for the robot selection problem of a new pharmaceutical city in Egypt for the first time. The source of data in this case study is experts, interviews, and questionnaires. Also, sensitivity and comparative analysis are further made for verifying the power of the proposed approach. The outcome of this study shows that the suggested approach for robot selection is quite helpful and has a great performance under uncertainty over classical and fuzzy ordinal priority approaches. Also, the suggested approach is less consumption of time and simpler than the fuzzy ordinal priority approach. Therefore, we recommend firms and governments to apply it for increasing product quality, hence the profitability of manufacturing industries and decrease needless costs. Supplementary Information: The online version contains supplementary material available at 10.1007/s40747-022-00721-w.

A new fusion of whale optimizer algorithm with Kapur's entropy for multi-threshold image segmentation: analysis and validations.

The separation of an object from other objects or the background by selecting the optimal threshold values remains a challenge in the field of image segmentation. Threshold segmentation is one of the most popular image segmentation techniques. The traditional methods for finding the optimum threshold are computationally expensive, tedious, and may be inaccurate. Hence, this paper proposes an Improved Whale Optimization Algorithm (IWOA) based on Kapur's entropy for solving multi-threshold segmentation of the gray level image. Also, IWOA supports its performance using linearly convergence increasing and local minima avoidance technique (LCMA), and ranking-based updating method (RUM). LCMA technique accelerates the convergence speed of the solutions toward the optimal solution and tries to avoid the local minima problem that may fall within the optimization process. To do that, it updates randomly the positions of the worst solutions to be near to the best solution and at the same time randomly within the search space according to a certain probability to avoid stuck into local minima. Because of the randomization process used in LCMA for updating the solutions toward the best solutions, a huge number of the solutions around the best are skipped. Therefore, the RUM is used to replace the unbeneficial solution with a novel updating scheme to cover this problem. We compare IWOA with another seven algorithms using a set of well-known test images. We use several performance measures, such as fitness values, Peak Signal to Noise Ratio, Structured Similarity Index Metric, Standard Deviation, and CPU time.

Hybrid Computational Intelligence Algorithm for Autonomous Handling of COVID-19 Pandemic Emergency in Smart Cities.

New cities exploit the smartness of the IoT-based architecture to run their vital and organizational processes. The smart response of pandemic emergency response services needs optimizing methodologies of caring and limit infection without direct connection with patients. In this paper, a hybrid Computational Intelligence (CI) algorithm called Moth-Flame Optimization and Marine Predators Algorithms (MOMPA) is proposed for planning the COVID-19 pandemic medical robot's path without collisions. MOMPA is validated on several benchmarks and compared with many CI algorithms. The results of the Friedman Ranked Mean test indicate the proposed algorithm can find the shortest collision-free path in almost all test cases. In addition, the proposed algorithm reaches an almost %100 success ratio for solving all test cases without constraint violation of the regarded problem. After the validation experiment, the proposed algorithm is applied to smart medical emergency handling in Egypt's New Galala mountainous city. Both experimental and statistical results ensure the prosperity of the proposed algorithm. Also, it ensures that MOMPA can efficiently find the shortest path to the emergency location without any collisions.

Two-Stage Deep Learning Framework for Discrimination between COVID-19 and Community-Acquired Pneumonia from Chest CT scans.

COVID-19 stay threatening the health infrastructure worldwide. Computed tomography (CT) was demonstrated as an informative tool for the recognition, quantification, and diagnosis of this kind of disease. It is urgent to design efficient deep learning (DL) approach to automatically localize and discriminate COVID-19 from other comparable pneumonia on lung CT scans. Thus, this study introduces a novel two-stage DL framework for discriminating COVID-19 from community-acquired pneumonia (CAP) depending on the detected infection region within CT slices. Firstly, a novel U-shaped network is presented to segment the lung area where the infection appears. Then, the concept of transfer learning is applied to the feature extraction network to empower the network capabilities in learning the disease patterns. After that, multi-scale information is captured and pooled via an attention mechanism for powerful classification performance. Thirdly, we propose an infection prediction module that use the infection location to guide the classification decision and hence provides interpretable classification decision. Finally, the proposed model was evaluated on public datasets and achieved great segmentation and classification performance outperforming the cutting-edge studies.

RCTE: A reliable and consistent temporal-ensembling framework for semi-supervised segmentation of COVID-19 lesions.

The segmentation of COVID-19 lesions from computed tomography (CT) scans is crucial to develop an efficient automated diagnosis system. Deep learning (DL) has shown success in different segmentation tasks. However, an efficient DL approach requires a large amount of accurately annotated data, which is difficult to aggregate owing to the urgent situation of COVID-19. Inaccurate annotation can easily occur without experts, and segmentation performance is substantially worsened by noisy annotations. Therefore, this study presents a reliable and consistent temporal-ensembling (RCTE) framework for semi-supervised lesion segmentation. A segmentation network is integrated into a teacher-student architecture to segment infection regions from a limited number of annotated CT scans and a large number of unannotated CT scans. The network generates reliable and unreliable targets, and to evenly handle these targets potentially degrades performance. To address this, a reliable teacher-student architecture is introduced, where a reliable teacher network is the exponential moving average (EMA) of a reliable student network that is reliably renovated by restraining the student involvement to EMA when its loss is larger. We also present a noise-aware loss based on improvements to generalized cross-entropy loss to lead the segmentation performance toward noisy annotations. Comprehensive analysis validates the robustness of RCTE over recent cutting-edge semi-supervised segmentation techniques, with a 65.87% Dice score.

FSS-2019-nCov: A deep learning architecture for semi-supervised few-shot segmentation of COVID-19 infection.

The newly discovered coronavirus (COVID-19) pneumonia is providing major challenges to research in terms of diagnosis and disease quantification. Deep-learning (DL) techniques allow extremely precise image segmentation; yet, they necessitate huge volumes of manually labeled data to be trained in a supervised manner. Few-Shot Learning (FSL) paradigms tackle this issue by learning a novel category from a small number of annotated instances. We present an innovative semi-supervised few-shot segmentation (FSS) approach for efficient segmentation of 2019-nCov infection (FSS-2019-nCov) from only a few amounts of annotated lung CT scans. The key challenge of this study is to provide accurate segmentation of COVID-19 infection from a limited number of annotated instances. For that purpose, we propose a novel dual-path deep-learning architecture for FSS. Every path contains encoder-decoder (E-D) architecture to extract high-level information while maintaining the channel information of COVID-19 CT slices. The E-D architecture primarily consists of three main modules: a feature encoder module, a context enrichment (CE) module, and a feature decoder module. We utilize the pre-trained ResNet34 as an encoder backbone for feature extraction. The CE module is designated by a newly introduced proposed Smoothed Atrous Convolution (SAC) block and Multi-scale Pyramid Pooling (MPP) block. The conditioner path takes the pairs of CT images and their labels as input and produces a relevant knowledge representation that is transferred to the segmentation path to be used to segment the new images. To enable effective collaboration between both paths, we propose an adaptive recombination and recalibration (RR) module that permits intensive knowledge exchange between paths with a trivial increase in computational complexity. The model is extended to multi-class labeling for various types of lung infections. This contribution overcomes the limitation of the lack of large numbers of COVID-19 CT scans. It also provides a general framework for lung disease diagnosis in limited data situations.

Smart Supervision of Cardiomyopathy Based on Fuzzy Harris Hawks Optimizer and Wearable Sensing Data Optimization: A New Model.

Cardiomyopathy is a disease category that describes the diseases of the heart muscle. It can infect all ages with different serious complications, such as heart failure and sudden cardiac arrest. Usually, signs and symptoms of cardiomyopathy include abnormal heart rhythms, dizziness, lightheadedness, and fainting. Smart devices have blown up a nonclinical revolution to heart patients' monitoring. In particular, motion sensors can concurrently monitor patients' abnormal movements. Smart wearables can efficiently track abnormal heart rhythms. These intelligent wearables emitted data must be adequately processed to make the right decisions for heart patients. In this article, a comprehensive, optimized model is introduced for smart monitoring of cardiomyopathy patients via sensors and wearable devices. The proposed model includes two new proposed algorithms. First, a fuzzy Harris hawks optimizer (FHHO) is introduced to increase the coverage of monitored patients by redistributing sensors in the observed area via the hybridization of artificial intelligence (AI) and fuzzy logic (FL). Second, we introduced wearable sensing data optimization (WSDO), which is a novel algorithm for the accurate and reliable handling of cardiomyopathy sensing data. After testing and verification, FHHO proves to enhance patient coverage and reduce the number of needed sensors. Meanwhile, WSDO is employed for the detection of heart rate and failure in large simulations. These experimental results indicate that WSDO can efficiently refine the sensing data with high accuracy rates and low time cost.

An intelligent framework using disruptive technologies for COVID-19 analysis.

This paper describes a framework using disruptive technologies for COVID-19 analysis. Disruptive technologies include high-tech and emerging technologies such as AI, industry 4.0, IoT, Internet of Medical Things (IoMT), big data, virtual reality (VR), Drone technology, and Autonomous Robots, 5 G, and blockchain to offer digital transformation, research and development and service delivery. Disruptive technologies are essential for Industry 4.0 development, which can be applied to many disciplines. In this paper, we present a framework that uses disruptive technologies for COVID-19 analysis. The proposed framework restricts the spread of COVID-19 outbreaks, ensures the safety of the healthcare teams and maintains patients' physical and psychological healthcare conditions. The framework is designed to deal with the severe shortage of PPE for the medical team, reduce the massive pressure on hospitals, and track recovered patients to treat COVID-19 patients with plasma. The study provides oversight for governments on how to adopt technologies to reduce the impact of unprecedented outbreaks for COVID-19. Our work illustrates an empirical case study on the analysis of real COVID-19 patients and shows the importance of the proposed intelligent framework to limit the current outbreaks for COVID-19. The aim is to help the healthcare team make rapid decisions to treat COVID-19 patients in hospitals, home quarantine, or identifying and treating patients with typical cold or flu.

A model for evaluating green credit rating and its impact on sustainability performance.

The development of economic activities and social progress index leads to the governmental considerations for the environmental challenge's issues. The Green Credit Policy (GCP) in China for manufacturing, as a part of a sustainable finance package, initiatives restrictions with suppliers to reduce harmful pollution for the environment. The study mainly validates the impact of GCP on manufacturing for diminishing the emerged pollution to the environment. The study develops Neutrosophic Multiple-Criteria Decision-Making Framework (N-MCDMF) according to neutrosophic theory and various MCDM methods of grey relational analysis (GRA), analytic network process (ANP), the Decision-Making Trial and Evaluation Laboratory technique (DEMATEL), and the Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS) to support the decision-makers with highly systematic procedures in the uncertain and inconsistent environmental conditions. The N-MCDMF evaluates the conditions of GCP and recommends the optimal Supply Chain Management (SCM) in manufacturing alternatives. A case study is presented for the validation of the issues of applicability and flexibility for the proposed N-MCDMF. The results obtained from the implementation of the N-MCDMF indicates the applicability and flexibility of the proposed approach. In addition, results show that SCM in manufacturing can provide more cooperation for the environment to reduce harmful pollution and to attain sustainability for achieving motivations under the restrictions of GCP.

HSMA_WOA: A hybrid novel Slime mould algorithm with whale optimization algorithm for tackling the image segmentation problem of chest X-ray images.

Recently, a novel virus called COVID-19 has pervasive worldwide, starting from China and moving to all the world to eliminate a lot of persons. Many attempts have been experimented to identify the infection with COVID-19. The X-ray images were one of the attempts to detect the influence of COVID-19 on the infected persons from involving those experiments. According to the X-ray analysis, bilateral pulmonary parenchymal ground-glass and consolidative pulmonary opacities can be caused by COVID-19 - sometimes with a rounded morphology and a peripheral lung distribution. But unfortunately, the specification or if the person infected with COVID-19 or not is so hard under the X-ray images. X-ray images could be classified using the machine learning techniques to specify if the person infected severely, mild, or not infected. To improve the classification accuracy of the machine learning, the region of interest within the image that contains the features of COVID-19 must be extracted. This problem is called the image segmentation problem (ISP). Many techniques have been proposed to overcome ISP. The most commonly used technique due to its simplicity, speed, and accuracy are threshold-based segmentation. This paper proposes a new hybrid approach based on the thresholding technique to overcome ISP for COVID-19 chest X-ray images by integrating a novel meta-heuristic algorithm known as a slime mold algorithm (SMA) with the whale optimization algorithm to maximize the Kapur's entropy. The performance of integrated SMA has been evaluated on 12 chest X-ray images with threshold levels up to 30 and compared with five algorithms: Lshade algorithm, whale optimization algorithm (WOA), FireFly algorithm (FFA), Harris-hawks algorithm (HHA), salp swarm algorithms (SSA), and the standard SMA. The experimental results demonstrate that the proposed algorithm outperforms SMA under Kapur's entropy for all the metrics used and the standard SMA could perform better than the other algorithms in the comparison under all the metrics.

DeepH-DTA: Deep Learning for Predicting Drug-Target Interactions: A Case Study of COVID-19 Drug Repurposing.

The rapid spread of novel coronavirus pneumonia (COVID-19) has led to a dramatically increased mortality rate worldwide. Despite many efforts, the rapid development of an effective vaccine for this novel virus will take considerable time and relies on the identification of drug-target (DT) interactions utilizing commercially available medication to identify potential inhibitors. Motivated by this, we propose a new framework, called DeepH-DTA, for predicting DT binding affinities for heterogeneous drugs. We propose a heterogeneous graph attention (HGAT) model to learn topological information of compound molecules and bidirectional ConvLSTM layers for modeling spatio-sequential information in simplified molecular-input line-entry system (SMILES) sequences of drug data. For protein sequences, we propose a squeezed-excited dense convolutional network for learning hidden representations within amino acid sequences; while utilizing advanced embedding techniques for encoding both kinds of input sequences. The performance of DeepH-DTA is evaluated through extensive experiments against cutting-edge approaches utilising two public datasets (Davis, and KIBA) which comprise eclectic samples of the kinase protein family and the pertinent inhibitors. DeepH-DTA attains the highest Concordance Index (CI) of 0.924 and 0.927 and also achieved a mean square error (MSE) of 0.195 and 0.111 on the Davis and KIBA datasets respectively. Moreover, a study using FDA-approved drugs from the Drug Bank database is performed using DeepH-DTA to predict the affinity scores of drugs against SARS-CoV-2 amino acid sequences, and the results show that that the model can predict some of the SARS-Cov-2 inhibitors that have been recently approved in many clinical studies.

Cosine similarity measures of bipolar neutrosophic set for diagnosis of bipolar disorder diseases.

Similarity plays a significant implicit or explicit role in various fields. In some real applications in decision making, similarity may bring counterintuitive outcomes from the decision maker's standpoint. Therefore, in this research, we propose some novel similarity measures for bipolar and interval-valued bipolar neutrosophic set such as the cosine similarity measures and weighted cosine similarity measures. The propositions of these similarity measures are examined, and two multi-attribute decision making techniques are presented based on proposed measures. For verifying the feasibility of proposed measures, two numerical examples are presented in comparison with the related methods for demonstrating the practicality of the proposed method. Finally, we applied the proposed measures of similarity for diagnosing bipolar disorder diseases.